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淫羊藿果实中的单萜衍生物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-23 DOI:10.1080/10286020.2025.2504964

Mi Li , Guo-Zhu Su , Hai-Qiang Wang , Xiao-Jing Wang , Li Li , Yu-Huan Li , Shuang-Gang Ma , Shi-Shan Yu

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引用次数: 0

摘要

从Illicium siymisii的果实中分离到三种先前未被描述的单萜衍生物illisimoncins A-C（1-3）和一种未被描述的2-甲酰基吡咯生物碱(4)，以及五种已知的单萜（5-9）。通过综合光谱分析对化合物1 ~ 4的结构进行了解析，并通过四乙酸二钼[Mo2(AcO)4]诱导的ICD实验和改进的Mosher法确定了它们的绝对构型。化合物2和7对柯萨奇B3病毒具有抗病毒活性，IC50值分别为57.74和23.24µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Monoterpene derivatives from the fruits of Illicium simonsii

Three previously undescribed monoterpene derivatives, illisimoncins A–C (1–3) and one undescribed 2-formylpyrrole alkaloid (4) were isolated from the fruits of Illicium simonsii together with five known monoterpenes (5-9). Structural elucidation of compounds 1-4 was elucidated through comprehensive spectroscopic analyses and their absolute configurations were determined by the dimolybdenum tetraacetate [Mo₂(AcO)₄]-induced ICD experiment and modified Mosher’s method. Compounds 2 and 7 showed antiviral activities against Coxsackievirus B3 with IC₅₀ values of 57.74 and 23.24 µM, respectively.

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来源期刊

Journal of Asian Natural Products Research

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

47

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.

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