绿原酸靶向SLC37A2，通过er依赖性NF-κB和NLRP3信号通路抑制巨噬细胞活化，对抗败血症诱导的急性肺损伤。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-27 DOI:10.1080/10286020.2025.2506181

Yang Chen, Xiao-Wen Zhang, Mei-Mei Zhao, Ling Li, Yang Liu, Tian-Tian Wei, Wei Yu, Bo Han, Zheng-Ping Liu, Ke-Wu Zeng

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引用次数: 0

摘要

脓毒症引起的急性肺损伤（SI-ALI）由于严重的炎症需要紧急治疗。我们的研究发现绿原酸（CGA）通过降低NO、TNF-α和IL-6来抑制lps诱导的巨噬细胞活化。基于tpp的策略确定SLC37A2为CGA的直接靶点，并通过CETSA/MST验证。分子对接显示为CGA-SLC37A2氢键。CGA通过SLC37A2通路减轻内质网应激，抑制TLR4/NF-κB和NLRP3通路，减轻炎症。在SI-ALI小鼠和斑马鱼模型中，CGA通过这些机制共同减轻了肺损伤。这项工作强调了CGA对SI-ALI的治疗潜力以及SLC37A2在对抗感染性肺炎中的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chlorogenic acid targets SLC37A2 to inhibit macrophage activation via ER-dependent NF-κB and NLRP3 signaling pathways against sepsis-induced acute lung injury.

Sepsis-induced acute lung injury (SI-ALI) requires urgent treatment due to severe inflammation. Our study found chlorogenic acid (CGA) suppressed LPS-induced macrophage activation by lowering NO, TNF-α, and IL-6. TPP-based strategies identified SLC37A2 as the direct target of CGA, validated by CETSA/MST. Molecular docking indicated CGA-SLC37A2 hydrogen bonding. CGA alleviated endoplasmic reticulum stress via SLC37A2, inhibiting TLR4/NF-κB and NLRP3 pathways to reduce inflammation. In SI-ALI mice and zebrafish models, CGA mitigated lung injury through these mechanisms taken together. This work highlights the therapeutic potential of CGA for SI-ALI and the critical role of SLC37A2 in combating infectious pneumonia.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.