扩大α硫辛酸对精神和神经健康的作用。

IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Ishu Garg, Harish Kumar, Raj Kumari, Anupama Singh, Ravi Maurya, Rashi Pandey, Shruti Bhatt
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引用次数: 0

摘要

随着全球范围内对健康和神经系统的关注的增加,营养保健品正在超越药物治疗的危害。硫辛酸是一种天然丰富的有机硫生物分子,对精神和神经疾病具有有效的保护和治疗作用。针对大脑中α -硫辛酸的研究已经得出结论,它可以调节氧化应激、神经元衰老、细胞凋亡、线粒体功能障碍、神经炎症、细胞信号传导、神经传递和受体功能。已经进行了各种临床研究,取得了令人满意的结果,表明α -硫辛酸作为神经退行性疾病和精神疾病的治疗剂。然而,将α -硫辛酸作为单一治疗药物并设计给药方案仍需进一步研究。本文旨在证明α -硫辛酸作为一种有效的生物分子治疗和预防精神和神经疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expanding the role of alpha lipoic acid for psychiatric and neurological health.

With the rise in health and neurological concerns around the globe, nutraceuticals are surpassing the harms of drug treatment. Alpha-lipoic acid, an organosulfur naturally abundant biomolecule that has potent protective and therapeutic effects in psychiatric and neurological disorders. Studies targeting alpha-lipoic acid in the brain have concluded that it modulates oxidative stress, neuronal aging, apoptosis, mitochondrial dysfunction, neuro-inflammation, cellular signaling, neurotransmission, and receptor functioning. Various clinical studies have been conducted, yielding satisfactory results indicating alpha-lipoic acid as a therapeutic agent for neurodegenerative and psychiatric disorders. However, further studies are still required to use alpha-lipoic acid as a monotherapeutic agent and to design a dosage regimen. The article aims to demonstrate alpha-lipoic acid as a potent biomolecule for curing and preventing psychiatric and neural disorders.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
47
审稿时长
2.3 months
期刊介绍: The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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