Synergistic effect and biochemical evaluation of kolaviron and quercetin on rat-model benign prostate hyperplasia.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-17 DOI:10.1080/10286020.2025.2501022

Ujong P Ujong, Mbang E Ibor, Iwara A Iwara, Mbeh U Eteng

引用次数: 0

Abstract

This study examined the effects of kolaviron and quercetin, individually and combined, on biochemical and histopathological changes in testosterone-induced benign prostatic hyperplasia (BPH) in male Wistar rats. Forty-two rats were divided into six groups, with BPH induced in all but the control group. Treatments included kolaviron, quercetin, their combination, and finasteride. BPH increased PSA, 5-α reductase, DHT, kidney and liver function markers, and altered lipid profiles. Treatments reduced these elevations and improved testosterone and HDL-c levels. Findings suggest that kolaviron and quercetin effectively ameliorate BPH, indicating their potential as affordable, non-invasive options for BPH management.

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克拉维铁与槲皮素对大鼠良性前列腺增生模型的协同作用及生化评价。

本研究探讨了可拉维铁和槲皮素单独和联合使用对雄性Wistar大鼠睾丸激素诱导的良性前列腺增生（BPH）的生化和组织病理学变化的影响。将42只大鼠分为6组，除对照组外，其余均诱发BPH。治疗包括可拉维铁、槲皮素及其联合治疗和非那雄胺。BPH增加PSA、5-α还原酶、DHT、肾和肝功能指标，并改变血脂谱。治疗降低了这些升高，改善了睾丸激素和HDL-c水平。研究结果表明，可拉维铁和槲皮素可有效改善BPH，表明它们有潜力成为BPH管理的可负担、非侵入性选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.