Two new abietane diterpenoids from Pinus massoniana.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-28 DOI:10.1080/10286020.2025.2509768

Xue Ma, Zhi-Long He, Bao Zhang, Li Jiang, Yong Huang, Yue-Ting Li, Yong-Jun Li

引用次数: 0

Abstract

Two new abietane diterpenoids, massonianene A (1) and massonianene B (2), were isolated from the extract of Pinus massoniana. Their structures were elucidated based on HR-ESI-MS, IR, UV, NMR, ECD and X-ray diffraction analysis. Compound 2 exhibited significant inhibitory effect against LPS-induced NO production in RAW 264.7 cells, with an IC₅₀ value of 7.00 ± 1.73 μM.

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马尾松中两个新枞烷二萜。

从马尾松提取物中分离得到两个新的枞烷二萜：马尾松烯A(1)和马尾松烯B(2)。通过IR、UV、NMR、ECD和x射线衍射分析对其结构进行了鉴定。化合物2对lps诱导的RAW 264.7细胞NO生成有显著抑制作用，IC50值为7.00±1.73 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.