Jia-Min Hu, Yi-Di Wu, Lu-Xi Cao, Xiao-Ning Nie, Jia-Ying Sun
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Study on effective substance in six kinds of Chinese herbal medicines containing phenylpropanoids and multi-target therapeutic mechanisms for treatment of hyperuricemia through in silico and in vitro experiments.
Hyperuricemia is an increasingly serious metabolic disease. However, xanthine oxidase inhibitors (XOIs) can fundamentally solve the problem of uric acid overproduction. In this paper, through virtual screening and network pharmacology, 73 potential compounds are discovered from six Chinese herbal medicines containing phenylpropanoids. These compounds treat hyperuricemia through crucial targets XDH, IL6, TLR4, HIF1A, HSP90AA1 and MMP2 synergistic effect. Further assay activities of inhibitory xanthine oxidase and antioxidant discover that taxifolin, morin and ellagic acid are deserved further study as the most promising anti-hyperuricemia multi-target XOIs candidates. Therefore, this study provides certain theoretical foundation for exploring effective treatment of hyperuricemia.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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