Ricson Pemimpin Hutagaol, Tjandrawati Mozef, Nurlela, Febi Nurilmala, Gian Primahana, Muhammad Eka Prasetya, Sofa Fajriah, Vionita Ristina
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Cytotoxic cycloartane-type triterpenoids from the leaves of aglaia shawiana.
Three cycloartane-type triterpenoids have been isolated from the leaves of Aglaia shawiana, and the structure was determined as a new compound Shawianin A (1), along with two known compounds cycloartane-3β,29-diol-24-one (2), and (24 R)-cycloartane-3β,24,25- triol (3). Their structures were elucidated on the basis of 1D and 2D-nuclear magnetic resonance (NMR) analysis, as well as high-resolution mass spectrometry (HR-MS), infrared (IR), and ultraviolet (UV). Comparative data analysis was also carried out with appropriate reference journals and through a biosynthesis approach of the cycloartane type of triterpene compound. All of the compounds were evaluated for their cytotoxic effects against MCF-7 breast cancer cells and showed cytotoxicity with IC50 values of >100 µg/ml.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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