人工培养担子菌木麻黄灵芝子实体中的Norlanostane三萜。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-25 DOI:10.1080/10286020.2025.2564414

Panida Chinthanom, Siriporn Saepua, Seangaroon Yoiprommarat, Kitlada Srichomthong, Thitiya Boonpratuang, Sujinda Sommai, Masahiko Isaka

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引用次数: 0

摘要

从担子菌灵芝（Ganoderma casuarinicola）培养的子实体中分离得到两个未描述的norlanostane三萜，ganocasuarinones B(1)和C(2)。化合物的结构被广泛的核磁共振光谱分析和质谱数据所阐明。采用改进的Mosher法建立了1的绝对构型。ganocasuinone C(2)对MCF-7人乳腺癌细胞具有选择性细胞毒性，IC50值为47µM。

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Norlanostane triterpenoids from artificially cultivated fruiting bodies of basidiomycete Ganoderma casuarinicola.

Two undescribed norlanostane triterpenoids, ganocasuarinones B (1) and C (2), were isolated from the cultivated fruiting bodies of basidiomycete Ganoderma casuarinicola. The structures of the compounds were elucidated by extensive NMR spectroscopic analyses and mass spectrometry data. The absolute configuration of 1 was established using the modified Mosher method. Ganocasuarinone C (2) exhibited selective cytotoxicity to MCF-7 human breast cancer cells with an IC₅₀ value of 47 µM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.