揭开开心散的神经保护奥秘：肠脑轴调节视角下神经保护成分的鉴定与验证。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-10-03 DOI:10.1080/10286020.2025.2468310

Jia-Le Ren , Xiao-Li Zhang , Li-Juan Zhao , Gui-Ying Wen , Jia-Fan Liu , Qing-Yu Meng , Zhen Yang , Li-Li Song , Yan-Jun Zhang

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引用次数: 0

摘要

开心散（KXS）具有治疗认知功能障碍的潜力，可以调节肠脑轴。然而，其有效成分尚不清楚。本研究检测了KXS提取物在血清、脑、心、肝、肺、肾和回肠中分布的成分。通过分析分布在不同组织中的鉴定成分的数量和浓度，得到KXS的潜在有效成分。然后，通过评估筛选的成分对a - β25-35诱导的SH-SY5Y细胞神经元凋亡的抑制能力进行验证。最终发现人参皂苷Rg1、人参皂苷Ro、α-asarone、2,4,5-三甲氧基苯甲酸和3′，6-二氨基蔗糖是KXS的潜在有效成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut – brain axis regulation

Kaixinsan (KXS) shows potential in treating cognitive dysfunction and can regulate the gut-brain axis. However, its effective components remain unclear. In this study, the components of KXS extract distributed in serum, brain, heart, liver, lung, kidney, and ileum were detected. By analyzing the number and the concentration of identified components distributed in different tissues, potential active components of KXS were obtained. Then, the screened components were confirmed by evaluating their ability to inhibit Aβ_25-35-induced neuronal apoptosis in SH-SY5Y cells. Finally, Ginsenoside Rg1, Ginsenoside Ro, α-asarone, 2,4,5-trimethoxybenzoic acid, and 3’,6-disinapoylsucrose were found to be the potential active ingredients of KXS.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.