A new polyketide, asperone A, isolated from the endophytic fungus Aspergillus versicolor JGC-G1 and its antifungal activity.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-15 DOI:10.1080/10286020.2025.2558637

Fang Yue, Ling-Yan Liu, Chang Li, Xu-Ri Wan, Xuan Lu, Yue-Hu Pei, Yi-Hui Yang

引用次数: 0

Abstract

ABSTRCTOne previously undescribed polyketide compound (1) and eight known ones (2-9) were isolated from the endophytic fungus Aspergillus versicolor JGC-G1. Their chemical structures were elucidated by HRESIMS, 1D and 2D NMR analysis, experimental ECD, and calculated ECD data. Nine polyketide compounds were assessed for antifungal activity against Candida albicans CMCC 98001 and Aspergillus niger R330. Compounds 1 and 7 showed significant antifungal effect against these two fungi, with the MICs ranging from 0.781 to 3.125 μg/ml.

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从内生真菌杂色曲霉JGC-G1中分离到一个新的聚酮物asperone A及其抗真菌活性。

摘要从内生真菌曲霉（Aspergillus versicolor） JGC-G1中分离得到1个先前未见的聚酮化合物(1)和8个已知的聚酮化合物（2-9）。通过hresms、1D和2D NMR分析、实验ECD和计算ECD数据对其化学结构进行了表征。9种聚酮类化合物对白色念珠菌cmcc98001和黑曲霉R330的抗真菌活性进行了评价。化合物1和7对这两种真菌均有显著的抑制作用，mic范围为0.781 ~ 3.125 μg/ml。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.