采用UHPLC-MS/MS对人参普通粉和超微颗粒粉中人参皂苷的药动学进行比较研究。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-16 DOI:10.1080/10286020.2025.2552200

Ya-Ran Teng, Saibire Aishana, Meng Zhang, Kai-Yue Zhang, Ren-Song Huang, Hui Li, Wei Wu

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引用次数: 0

摘要

采用UHPLC-MS/MS对人参超微颗粒粉（UGP）与普通粉（CP）进行了比较。UGP具有较高的溶解度和较快的溶解速度。SD大鼠的相对生物利用度显著提高（Rc/Rb2/Rb1/Re/Rd: +113.80%, +104.80%, +81.37%, +70.62%, +33.54%）。在UGP和CP中，Re分别在2 h和4 h达到Cmax，呈现双峰。Rb1的Cmax最高（400.82 vs 220.20 ng/ml）。观察到的改善可能是由于UGP的粒径减小和表面积增加。这些数据支持优化人参的临床使用和配方。

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Comparative pharmacokinetic studies on ginsenosides in the common and ultrafine granular powder of Panax ginseng by using UHPLC-MS/MS.

Using UHPLC-MS/MS, we compared ginseng ultrafine granular powder (UGP) with common powder (CP). UGP showed higher solubility and faster dissolution. In SD rats, relative bioavailability increased markedly (Rc/Rb2/Rb1/Re/Rd: +113.80%, +104.80%, +81.37%, +70.62%, +33.54%). Re reached Cmax at 2 h in UGP vs 4 h in CP and showed a double peak. Rb1 had the highest Cmax (400.82 vs 220.20 ng/ml). The observed improvements may be attributable to the reduced particle size and increased surface area of UGP. These data support optimized clinical use and formulation of ginseng.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.