III型后iboga生物碱全合成研究进展。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-22 DOI:10.1080/10286020.2025.2558642

Xian-Yue Zhang, Xin Wang, Yue-Jie Zhu, Hong-Yan Shen, Guang Li

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引用次数: 0

摘要

后伊博加生物碱的全合成带来了巨大的挑战。到目前为止，有三个小组通过他们的努力取得了显著的进展。Sunkyu Han的团队采用开环功能化方法来完成半合成。韩富社研究小组采用不对称Michael/aldol串联反应构建了aza-[3.3.1]桥接骨架。Namba的团队报道了一种单锅串联环化策略，以快速组装（±）-tronocarpine的五环核心。本文综述了2019年以来III型后iboga生物碱的合成进展，重点介绍了关键的战略要素和合成里程碑，旨在启发未来对这一独特家族的全合成的努力。

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Recent advances in the total synthesis of type III post-Iboga alkaloids.

The total synthesis of post-Iboga alkaloids poses formidable challenges. So far, three groups have produced notable advancements through their endeavor. Sunkyu Han's group employed a ring-opening functionalization approach to accomplish semi-synthesis. Fu-she Han's group developed an asymmetric Michael/aldol tandem reaction to construct the aza-[3.3.1] bridged skeleton. Namba's group reported a one-pot tandem cyclization strategy to rapidly assemble the pentacyclic core of (±)-tronocarpine. This review focuses on the synthetic advances made from 2019 onward toward type III post-Iboga alkaloids, highlighting key strategic elements and synthetic milestones, and aims to inspire future endeavors in the total synthesis of this unique family.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.