Structural elucidation of anti-inflammatory withanolides from Physalis minima.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-29 DOI:10.1080/10286020.2025.2564404

Zhu Yang, Kai-Xiang Tong, Qiu-Yue Lv, Song-Zi Xie, Jiang-Ping Wu, Jun Han, Zhong-Mei Zou

引用次数: 0

Abstract

The investigation of the whole plants of Physalis minima led to the isolation of four novel withanolides, designated phyminiolides F-I, together with six known analogues. The structures of 1-4 were elucidated through comprehensive analysis of their spectroscopic data, including HRESIMS, NMR and ECD, while those of 5-10 were identified by comparing their spectroscopic data with the reported literature values. Biologically, compounds 1, 3-4, and 8-10 exhibited moderate anti-inflammatory activities by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 cells in vitro, with IC₅₀ values ranging from 8.72 to 23.28 μM.

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小泡Physalis minima抗炎withanolides的结构分析。

通过对小绒Physalis minima整个植物的研究，分离出了4种新的withanolides，命名为phyminiolides F-I，以及6种已知的类似物。1 ~ 4号化合物的结构通过hresms、NMR和ECD等光谱数据进行综合分析，5 ~ 10号化合物的结构通过与文献报道值的比较进行鉴定。生物学上，化合物1、3-4和8-10通过抑制脂多糖（LPS）刺激小鼠RAW 264.7细胞中一氧化氮（NO）的产生而表现出中等的抗炎活性，IC50值在8.72 ~ 23.28 μM之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.