Case Reports in Gastroenterology最新文献

{"title":"Erratum.","authors":"","doi":"10.1159/000551337","DOIUrl":"https://doi.org/10.1159/000551337","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1159/000549436.].</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"84"},"PeriodicalIF":0.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectal Gastrointestinal Stromal Tumor Complicated by Tumor Lysis Syndrome after Imatinib Initiation: A Rare and Fatal Case.","authors":"Cyrine Louati, Karima Tlili, Asma Dahmane, Faten Gargouri, Nada Mansouri, Issam Msakni","doi":"10.1159/000550905","DOIUrl":"https://doi.org/10.1159/000550905","url":null,"abstract":"<p><strong>Introduction: </strong>Gastrointestinal stromal tumors (GISTs) are rare mesenchymal connective tumors. They generally develop from the gastric or intestinal wallor. Rectal location is rare. In fact, rectal GISTs account for 5% of cases and 0.1% of all rectal tumors.</p><p><strong>Case presentation: </strong>We report the case of a stromal tumor of rectal localization in order to study the clinical, anatomopathological and radiological particularities of this entity. We report the case of a 73-year-old patient who was initially admitted for a stent placement. A rectoscopy showed a half circumferential rectal process. It was situated at 2 cm from the anal verge. The magnetic resonance imaging of the pelvis showed a large tumor of the lower rectum, with a focal rupture of the right rectal wall and invading the sphincter apparatus. Pathological examination revealed a proliferation of spindle-shaped cells with abundant cytoplasm and ovoid atypical nuclei with a high mitotic index. The immunohistochemical study showed that the tumor cells were positive for CKit and DOG1 and negative for AML and PS100. The retained diagnosis was high-risk spindle cell GIST.</p><p><strong>Conclusion: </strong>Rectal GISTs are rare tumors. Diagnosis is based on anatomopathological examination with immunohistochemical study. Surgical resection is the standard treatment for localized GIST. Imatinib is the first-line prescribed treatment, with particular attention to potentially life-threatening adverse effects.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"92-99"},"PeriodicalIF":0.6,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grade 1 Hepatic Neuroendocrine Tumor with Peritoneal Metastases: Case Report - Diagnostic Reasoning and Management Challenges.","authors":"Tsung-Lun Tsai, Jiun-Wen Guo, Chin-Long Lin, Heng-Hui Lien","doi":"10.1159/000550941","DOIUrl":"https://doi.org/10.1159/000550941","url":null,"abstract":"<p><strong>Introduction: </strong>Neuroendocrine tumors are rare neoplasms that commonly metastasize to the liver, while peritoneal metastases occur less frequently but are associated with poorer outcomes. This report presents a rare case of concurrent liver metastasis and peritoneal metastasis from a well-differentiated neuroendocrine tumor, emphasizing the diagnostic reasoning and multidisciplinary management involved.</p><p><strong>Case presentation: </strong>A 62-year-old woman with a history of laparoscopic cholecystectomy was incidentally found to have multiple hypoechoic liver lesions and a mesenteric mass. Contrast-enhanced computed tomography and magnetic resonance imaging revealed hepatic and peritoneal nodules consistent with metastatic disease. Laparoscopic wedge resection of hepatic segments VI and VIII and biopsy of peritoneal implants confirmed a grade 1 neuroendocrine tumor positive for chromogranin A, synaptophysin, and INSM1, with a Ki-67 index of 2-3%. The patient underwent cytoreductive debulking surgery, achieving approximately 70% tumor reduction, followed by long-acting octreotide therapy. Postoperative recovery was uneventful, and follow-up imaging demonstrated no recurrence.</p><p><strong>Conclusion: </strong>This case report underscores the importance of early recognition and a multidisciplinary approach in managing indolent neuroendocrine tumors with multisite metastases. Combined surgical and medical strategies, including debulking surgery and octreotide therapy, can achieve durable disease control and favorable outcomes.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"108-114"},"PeriodicalIF":0.6,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidental Caustic Exposure from Ingestion of Contaminated Beer: A Case Series.","authors":"Lauren Canaff, Taylor A Hagans, Emily Carter, Frank Nemec","doi":"10.1159/000551052","DOIUrl":"10.1159/000551052","url":null,"abstract":"<p><strong>Introduction: </strong>This report presents three cases of unintentional ingestion of beer line cleaner (BLC), a strongly caustic alkaline solution (pH 13-14). In each incident, unflushed BLC entered the draft system and was served as drinkable beer (pH 4.0-4.5) in different taverns due to deficiencies in regulatory oversight and enforcement.</p><p><strong>Case presentations: </strong>A 37-year-old female, a 37-year-old male, and a 40-year-old male presented with esophageal injuries after consuming contaminated beer in unrelated events. Endoscopy revealed findings ranging from erythema and esophageal nodules to benign strictures and very severe Grade D esophagitis. Patients required extended proton pump inhibitor therapy and dietary changes, and they experienced ongoing symptoms, including dysphagia, reflux, taste alterations, and weight loss.</p><p><strong>Conclusion: </strong>This case series highlights the serious and lasting consequences of BLC ingestion and underscores the need for standardized beer line flushing protocols, tracer dyes, and point-of-use testing to prevent future exposures in commercial establishments where uniform regulations are insufficient. It also demonstrates the underreported health risks associated with accidental BLC ingestion. Greater physician awareness can facilitate earlier diagnosis and treatment and improve outcomes. Enhanced reporting of BLC ingestion can increase identification of caustic hazards and strengthen public health awareness of this largely unrecognized risk.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"72-77"},"PeriodicalIF":0.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13030902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sigmoid Colon Obstruction due to Gallstone Ileus: Case Report.","authors":"Said Al Alawi, Lu Kun Chen, Kevin Axel Waschke","doi":"10.1159/000551179","DOIUrl":"https://doi.org/10.1159/000551179","url":null,"abstract":"<p><strong>Introduction: </strong>Gallstone ileus of the colon is a rare cause of large bowel obstruction, usually caused by a gallbladder-to-colon fistula allowing stone entry. The classical presentation is with episodic subacute obstruction. Contrast-enhanced CT is valuable for diagnosis, with surgery being the preferred treatment; however, endoscopic therapy has been described and may also be attempted.</p><p><strong>Case presentation: </strong>We describe the case of an 81-year-old female with a medical history significant for atrial fibrillation and congestive heart failure. She presented with a 2-week history of constipation, abdominal pain, distention, nausea, and vomiting. Clinically, her abdomen was distended but without signs of peritonitis. A CT scan showed a cholecystoduodenal fistula, along with a 3.3-cm gallstone causing a large bowel obstruction at the sigmoid colon. An attempt at flexible sigmoidoscopy to remove the stone failed due to its size and distal hypertrophy. The patient underwent exploratory laparotomy and Hartmann's procedure to relieve the obstruction and remove the gallstone.</p><p><strong>Conclusion: </strong>Gallstone ileus remains an uncommon but clinically important cause of mechanical bowel obstruction, typically occurring in elderly patients with significant comorbidities. This case underscores an especially rare manifestation - large bowel obstruction secondary to gallstone ileus - which can pose diagnostic and therapeutic challenges and is easily overlooked. By illustrating this atypical presentation, our report highlights the need for heightened clinical suspicion in older patients presenting with bowel obstruction and pneumobilia. Furthermore, it emphasizes the spectrum of available management strategies and the importance of individualized decision-making based on patient frailty, anatomical considerations, and surgical risk.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"100-107"},"PeriodicalIF":0.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13095195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adebrelimab Combined with Chemotherapy for Esophageal Neuroendocrine Carcinoma: A Case Report.","authors":"Yan-Ge Zhao, Tong Zhao, Kun Ma, Shao-Xuan Wang","doi":"10.1159/000550931","DOIUrl":"https://doi.org/10.1159/000550931","url":null,"abstract":"<p><strong>Introduction: </strong>Esophageal neuroendocrine carcinoma is an extremely rare type of esophageal cancer. Due to the limited number of cases, there are no established diagnostic and treatment guidelines.</p><p><strong>Case presentation: </strong>A 60-year-old male presented with dysphagia and was subsequently diagnosed with large cell neuroendocrine carcinoma of the esophagus. He received four cycles of treatment with adebrelimab combined with etoposide and carboplatin, which resulted in significant tumor shrinkage.</p><p><strong>Conclusion: </strong>Esophageal neuroendocrine carcinoma is a highly malignant tumor with a high mortality rate. A better understanding of its diagnosis and treatment strategies may contribute to favorable trends in patient outcomes, while its actual effect on long-term prognosis remains to be validated with extended follow-up.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"85-91"},"PeriodicalIF":0.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of Takayasu Arteritis and Chronic Recurrent Multifocal Osteomyelitis during Maintenance Therapy in Remission 13 Years after the Diagnosis of Very Early-Onset Ulcerative Colitis: A Case Report.","authors":"Yuriko Yamane, Kunio Hashimoto, Ai Yuda, Michiyo Sasaki","doi":"10.1159/000551171","DOIUrl":"10.1159/000551171","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory bowel disease (IBD) is associated with Takayasu arteritis (TAK). Chronic recurrent multifocal osteomyelitis (CRMO) is a nonbacterial osteomyelitis that occurs at multiple sites, some of which are associated with IBD. We herein report a pediatric patient diagnosed with CRMO and TAK 13 years after the onset of very early-onset ulcerative colitis (VEO-UC). Concurrent presentations of UC, TAK, and CRMO are extremely rare.</p><p><strong>Case presentation: </strong>A 15-year-old female diagnosed with VEO-UC at 22 months developed CRMO and TAK 13 years later despite maintained remission on infliximab. The patient was presented with knee pain and fever. 18-fluorodeoxyglucose positron emission tomography revealed not only multiple bone uptake but also arterial wall thickening. Contrast-enhanced magnetic resonance imaging showed circumferential wall thickening from distal aortic arch to descending aorta. Bone biopsy confirmed chronic osteomyelitis without infection. TAK (type IIb) and CRMO were diagnosed. Methylprednisolone pulse therapy was administered for induction. Treatment was switched to adalimumab (ADA), which has reported efficacies for all three conditions. However, only TAK did not achieve remission. ADA was switched to tocilizumab (TCZ) without changing other medications to treat TAK, successfully achieving remission of all three diseases and allowing steroid reduction.</p><p><strong>Conclusion: </strong>Clinicians should consider concurrent vasculitis and CRMO when IBD patients present with unexplained inflammatory responses. TCZ may effectively treat TAK developing in anti-tumor necrosis factor-treated UC patients.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"63-71"},"PeriodicalIF":0.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13030904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete Rectal Anastomotic Occlusion That Spontaneously Recanalized, Allowing for Unusual Endoscopic Treatment with a Lumen-Apposing Metal Stent: A Case Report.","authors":"Tal Weiss, Mark Kirshon, Veacheslav Zilbermints, Neev Tchernin, Boris Kessel, Oren Gal","doi":"10.1159/000550955","DOIUrl":"https://doi.org/10.1159/000550955","url":null,"abstract":"<p><strong>Introduction: </strong>Complete anastomotic occlusion following rectal surgery is a rare and challenging complication. While surgical revision remains the standard treatment, it is associated with significant morbidity. Recently, novel endoscopic techniques have emerged as minimally invasive alternatives.</p><p><strong>Case presentation: </strong>We report the case of a 64-year-old patient who developed complete rectal anastomotic occlusion after low anterior resection and declined further surgery. Five months later, spontaneous recanalization was observed, allowing for successful endoscopic treatment using a lumen-apposing metal stent (LAMS). The stent was later removed, and ileostomy reversal was completed successfully.</p><p><strong>Conclusion: </strong>Watchful surveillance for spontaneous recanalization may offer a safe opportunity for endoscopic intervention in selected high-risk, diverted patients with complete rectal anastomotic occlusion. LAMS may serve as an effective alternative to fully covered self-expandable metal stents in cases of severe strictures.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"78-83"},"PeriodicalIF":0.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PTCD-Assisted ERCP for Severe Stricture at the Biliary-Enteric Anastomosis following Pancreaticoduodenectomy: A Case Report.","authors":"Zhen Lv, Kangjie Chen","doi":"10.1159/000550565","DOIUrl":"https://doi.org/10.1159/000550565","url":null,"abstract":"<p><strong>Introduction: </strong>Post-pancreaticoduodenectomy (PD) biliary-enteric anastomosis stenosis (BEAS) poses substantial therapeutic challenges secondary to surgically altered anatomy. Conventional endoscopic interventions are frequently unsuccessful in patients with both altered gastrointestinal anatomy and severe fibrotic strictures. This study reports the utilization of a combined percutaneous transhepatic cholangiodrainage (PTCD) and endoscopic retrograde cholangiopancreatography (ERCP) rendezvous technique, incorporating an innovative mechanical dilation method using a stent retriever, for the management of refractory BEAS.</p><p><strong>Case presentation: </strong>A 50-year-old male who had undergone PD developed recurrent cholangitis due to BEAS, which was confirmed by magnetic resonance cholangiopancreatography (MRCP). Previous attempts to access the anastomosis via conventional ERCP and to dilate the stricture using a standard PTCD-based approach were unsuccessful. Consequently, a novel hybrid approach that utilized both PTCD for access and endoscopic therapy for treatment was employed. The procedure involved advancing a guidewire through the PTCD tract into the jejunal lumen under fluoroscopic guidance, which was then endoscopically retrieved using foreign body forceps. Bidirectional traction stabilized the access route, enabling gastroscopic navigation to the anastomosis. For the refractory stenosis, controlled mechanical dilation was performed using a stent retriever for rotational drilling, followed by balloon dilation and placement of a nasobiliary catheter.</p><p><strong>Conclusions: </strong>This hybrid approach integrates percutaneous and endoscopic modalities to overcome anatomical barriers in complex BEAS. The innovative use of a stent retrieval device for controlled mechanical dilation provides a salvage option when standard devices fail. This strategy demonstrates technical feasibility and efficacy for refractory BEAS, expanding therapeutic possibilities in challenging post-surgical anatomy.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"46-53"},"PeriodicalIF":0.6,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Bleeding due to Intussuscepted Duodenal Lipoma: A Case Report.","authors":"Sylvia Machann, Eliane Angst, Urs Derungs, Anna Bingisser","doi":"10.1159/000550678","DOIUrl":"10.1159/000550678","url":null,"abstract":"<p><strong>Introduction: </strong>Duodenal lipomas are rare benign tumors which are typically asymptomatic but may cause significant gastrointestinal symptoms.</p><p><strong>Case presentation: </strong>This case shows an uncommon presentation of duodenal intussusception due to a lipoma in a 65-year-old male patient, presenting with melena, hypotension, and vertigo. Upon investigation, a CT scan revealed a 5.7 × 7.1 cm lipomatous mass in the duodenum. Endoscopy confirmed the presence of associated bleeding. Despite initial management with proton pump inhibitors and blood transfusions, the patient required emergency endoscopic interventions for persistent bleeding. A subsequent laparotomy revealed an intussusception of the lipoma into the second part of the duodenum, thus also affecting the gastric antrum. The patient underwent distal gastrectomy and resection of the first part of the duodenum, followed by Roux-Y reconstruction. Histology showed that the submucosal lipoma originated from the first part of the duodenum.</p><p><strong>Conclusion: </strong>This case highlights the rarity of duodenal lipoma as a cause of duodenal intussusception and emphasizes the diagnostic challenges associated with the identification of this condition in adults. Furthermore, it highlights the importance of an interdisciplinary team approach to manage this rare condition effectively.</p>","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"20 1","pages":"54-62"},"PeriodicalIF":0.6,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}