Case Reports in Gastroenterology最新文献_第10页

Progression of Recurrent Pancreatitis to Chronic Pancreatitis within 3 Years due to SPINK1 Mutation IVS3+2T>C. 3年内因SPINK1突变IVS3+2T>C导致的复发性胰腺炎进展为慢性胰腺炎

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000528768

Susumu Horitani, Masahiro Tsujimae, Arata Sakai, Atsuhiro Masuda, Kae Nagao, Shinya Kohashi, Noriko Inomata, Hisahiro Uemura, Shigeto Masuda, Masanori Gonda, Shohei Abe, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Takeshi Tanaka, Ryota Nakano, Takashi Kobayashi, Hideyuki Shiomi, Yuzo Kodama

{"title":"Progression of Recurrent Pancreatitis to Chronic Pancreatitis within 3 Years due to SPINK1 Mutation IVS3+2T>C.","authors":"Susumu Horitani, Masahiro Tsujimae, Arata Sakai, Atsuhiro Masuda, Kae Nagao, Shinya Kohashi, Noriko Inomata, Hisahiro Uemura, Shigeto Masuda, Masanori Gonda, Shohei Abe, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Takeshi Tanaka, Ryota Nakano, Takashi Kobayashi, Hideyuki Shiomi, Yuzo Kodama","doi":"10.1159/000528768","DOIUrl":"https://doi.org/10.1159/000528768","url":null,"abstract":"When the etiology of pancreatitis cannot be determined despite sufficient investigation, recurrence and progression to chronic pancreatitis often involve genetic mutations. Herein, we describe a case of recurrent pancreatitis with the IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene that progressed to chronic pancreatitis in only 3 years. A 35-year-old man was referred to our hospital, where he was diagnosed with mild pancreatitis and was treated conservatively. However, the patient experienced recurrent episodes of pancreatitis, which progressed to become chronic pancreatitis with a pancreatic calcification 1 year later. After 3 years, the patient developed pancreatic duct stenosis and required a pancreatic duct stent placement. Regarding the cause of chronic pancreatitis, alcohol abuse was ruled out based on history taking. Considering the course of treatment, autoimmune pancreatitis and obstructive pancreatitis, such as pancreatic divisum, were also ruled out. Finally, a germline genetic test was performed to determine the etiology of pancreatitis, which revealed the IVS3+2T>C mutation in SPINK1. This case shows the importance of genetic testing in patients with idiopathic pancreatitis to determine their etiology and is a rare incident that can report the progression of the disease from acute to chronic pancreatitis.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"17 1","pages":"49-55"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/39/crg-2022-0017-0001-528768.PMC9891844.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10661685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefit of Continuation of Low-Dose Imatinib for Gastrointestinal Stromal Tumors despite Adverse Events with Regular-Dose Imatinib. 尽管常规剂量伊马替尼有不良事件，但继续使用低剂量伊马替尼治疗胃肠道间质肿瘤的益处

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000529002

Ryo Katsumata, Yasumasa Monobe, Yosuke Katata, Hideyo Fujiwara, Takashi Urano, Akihisa Akagi, Kotone Tsujimoto, Takako Konishi, Noriaki Manabe, Tomoari Kamada, Hirofumi Kawamoto, Tomoki Yamatsuji, Yoshio Naomoto

{"title":"Benefit of Continuation of Low-Dose Imatinib for Gastrointestinal Stromal Tumors despite Adverse Events with Regular-Dose Imatinib.","authors":"Ryo Katsumata, Yasumasa Monobe, Yosuke Katata, Hideyo Fujiwara, Takashi Urano, Akihisa Akagi, Kotone Tsujimoto, Takako Konishi, Noriaki Manabe, Tomoari Kamada, Hirofumi Kawamoto, Tomoki Yamatsuji, Yoshio Naomoto","doi":"10.1159/000529002","DOIUrl":"https://doi.org/10.1159/000529002","url":null,"abstract":"Tyrosine kinase inhibitors (TKIs) such as imatinib improve the prognosis of patients with gastrointestinal stromal tumors (GISTs). However, treatment options for GISTs are still limited, and the continuation of TKIs is difficult due to adverse events in some cases. The effectiveness of low-dose imatinib is unclear. We report 2 cases to show effectiveness of low-dose imatinib in patients with adverse events. The first case is a male in his early 60s with a history of intestinal GIST resection who was diagnosed with recurrent GIST with peritoneal dissemination. He was started on low-dose imatinib (300 mg) because of a history of subconjunctival hemorrhage after receiving postoperative imatinib. Follow-up contrast-enhanced ultrasonography revealed that the tumors had shrunk in size and number after 2 months of treatment with 300-mg imatinib. He continued this treatment and showed partial response for 8 months. The second case is a female in her late 70s with rectal GIST who was treated with imatinib 400 mg. Due to a severe skin lesion, she changed her treatment to sunitinib 2 months after initiation. However, new metastasis in the liver was confirmed after 4 months of administration of sunitinib. She underwent surgical esection of the rectal tumor to reduce the volume. After the surgery, low-dose imatinib (300 mg) with oral steroids was adopted. Follow-up confirmed the absence of recurrence at the rectum and no increase in hepatic tumor size for 18 months. Aggressive treatment with low-dose imatinib instead of discontinuation or alteration of treatment may benefit patients with unresectable and postoperative GISTs with sensible mutation to imatinib.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"17 1","pages":"109-116"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/71/crg-2022-0017-0001-529002.PMC9938401.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Granular Cell Tumor of the Ascending Colon. 升结肠颗粒细胞瘤。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000529170

Samyak Dhruv, Kuldeepsinh P Atodaria, Dhineshreddy Gurala, Talal El Imad, Jeffrey Abergel

引用次数: 0

Hypereosinophilic Syndrome Secondary to Ulcerative Colitis and Primary Sclerosing Cholangitis. 继发于溃疡性结肠炎和原发性硬化性胆管炎的嗜酸性粒细胞增多综合征。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000527380

Davi Viana Ramos, Diogo Delgado Dotta, Luísa Leite Barros

引用次数: 0

Endoscopic Laryngopharyngeal Surgery Combined with Endoscopic Submucosal Dissection as a Treatment Option for Superficial Hypopharyngeal Cancer with Suspected Synchronous Lymph Node Metastasis. 内镜下咽手术联合内镜下粘膜剥离术治疗怀疑有同步淋巴结转移的浅表性下咽癌。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000528424

Shinya Sugimoto, Tomohito Fuke, Daisuke Kobayashi, Mamika Kaneko, Taishi Temma, Tatsuma Nomura, Nobuyuki Tsuda, Mayu Kawabata, Ryutaro Matsushima, Hirohisa Hisada, Satoshi Hayashi, Toji Murabayashi, Jun Oyamada, Akira Kamei, Nobukazu Fuwa, Tadashi Yabana, Hiroyuki Yamada, Hayato Nakagawa

{"title":"Endoscopic Laryngopharyngeal Surgery Combined with Endoscopic Submucosal Dissection as a Treatment Option for Superficial Hypopharyngeal Cancer with Suspected Synchronous Lymph Node Metastasis.","authors":"Shinya Sugimoto, Tomohito Fuke, Daisuke Kobayashi, Mamika Kaneko, Taishi Temma, Tatsuma Nomura, Nobuyuki Tsuda, Mayu Kawabata, Ryutaro Matsushima, Hirohisa Hisada, Satoshi Hayashi, Toji Murabayashi, Jun Oyamada, Akira Kamei, Nobukazu Fuwa, Tadashi Yabana, Hiroyuki Yamada, Hayato Nakagawa","doi":"10.1159/000528424","DOIUrl":"https://doi.org/10.1159/000528424","url":null,"abstract":"We report 4 cases of hypopharyngeal cancer preoperatively suspected with synchronous lymph node metastases. Pathologic lymph node metastasis was confirmed in three of the four cases. All 4 cases underwent endoscopic laryngopharyngeal surgery (ELPS) combined with endoscopic submucosal dissection (ESD) and subsequent lymph node dissection as an optional treatment rather than the standard treatment. Peroral resection for primary site was selected because of the expected decline in quality of life (QoL) after radical surgery. Among 4 patients, one developed local recurrence; however, the other three remained recurrence-free and survived without any additional treatment. Furthermore, the patient who developed local recurrence had a recurrence-free survival for more than 5 years, with additional chemoradiation therapy. No disorders in speech, swallowing, or breathing was observed during the follow-up period. ELPS combined with ESD is generally indicated for laryngopharyngeal cancer without synchronous lymph node metastasis. However, this can be a treatment option for patients may wish to preserve a greater QoL after treatment. In the future, when more data on the results and long-term prognosis of this treatment are accumulated, it may be possible to discuss its validity further.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"17 1","pages":"1-13"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/17/crg-2022-0017-0001-528424.PMC9841794.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10550787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric Metastasis 5 Years after Primary Invasive Lobular Adenocarcinoma of the Breast. 原发性浸润性乳腺小叶腺癌后5年发生胃转移。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000528506

Dongmin Shin, Haozhe Sun, Nikhitha Mantri, Harish Patel

引用次数: 0

Right Hepatic and Portal Vein Embolization before Right Hepatectomy for Colorectal Cancer Liver Metastases. 结直肠癌肝转移的右肝切除术前右肝及门静脉栓塞治疗。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000529909

Eduardo E Montalvo-Javé, Edwin A Ayala-Moreno, Alejandro Rossano García, Alejandro Díaz Girón Gidi, Jorge Guerrero Ixtlahuac

{"title":"Right Hepatic and Portal Vein Embolization before Right Hepatectomy for Colorectal Cancer Liver Metastases.","authors":"Eduardo E Montalvo-Javé, Edwin A Ayala-Moreno, Alejandro Rossano García, Alejandro Díaz Girón Gidi, Jorge Guerrero Ixtlahuac","doi":"10.1159/000529909","DOIUrl":"https://doi.org/10.1159/000529909","url":null,"abstract":"Colon cancer has had a significant increase in its incidence in recent years. Many of the cases are diagnosed late; it is not unusual that a large number of cases present metastatic disease at the time of diagnosis, and the liver is the main organ where these lesions occur. Surgical approach to this condition has undergone many advances which have allowed a better approach to them. Local techniques such as embolization have gained momentum in recent years and are a great help to the surgical planning. We present the case of a 72-year-old female patient diagnosed with colorectal cancer and metastatic disease. Multiple liver tumors were demonstrated by imaging studies. A staged resection of the primary tumor and the metastatic hepatic tumors was planned. It was decided to perform an embolization of the hepatic artery to cause hypertrophy of the left lobe before the second stage of the surgical approach with good clinical and laboratorial findings after the surgery. Follow-up with adjuvant chemotherapy, imaging studies and tumor markers is planned. Several publications state that surgical approach of metastatic disease is still controversial and that decisions should be made under the context of each patient. Many techniques have shown good results; embolization of the hepatic tumors has a good outcome in the survival rate in selected patients. Hepatic volume and future liver remnant should be always assessed with imaging studies. Each case has to be individualized for the approach of the metastatic disease, always in a coordinated teamwork for maximum benefit of the patient.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"17 1","pages":"212-220"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectal Melanoma: Rare Cancer with Grave Prognosis. 直肠黑色素瘤:预后严重的罕见癌症。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000529434

Khadija Soufi, Ferheen Abbasi, Dongguang Wei, Rashmi Verma

{"title":"Rectal Melanoma: Rare Cancer with Grave Prognosis.","authors":"Khadija Soufi, Ferheen Abbasi, Dongguang Wei, Rashmi Verma","doi":"10.1159/000529434","DOIUrl":"https://doi.org/10.1159/000529434","url":null,"abstract":"Malignant melanoma of the rectum is an exceedingly rare type of cancer with an aggressive presentation, comprising up to 4% of all anorectal cancers. Presentation of this cancer tends to occur in individuals in their late 80s, with nonspecific symptoms such as anal pain or rectal bleeding. Diagnosing rectal melanoma, especially in early stages, is difficult due to its amelanotic presentation and lack of pigmentation, which results in poor remission rates and prognosis. Furthermore, surgical treatment is difficult as these types of malignant melanomas tend to spread along submucosal planes; thus, complete resections are impractical, especially if caught later. In this case report, we present the radiological and pathological features as seen in a 76-year-old man diagnosed with rectal melanoma. Based on his presentation of a heterogeneous bulky anorectal mass with extensive local invasion, initial impressions were colorectal carcinoma. However, surgical pathology found the mass to be a c-KIT+ melanoma, with positive SOX10, Melan-A, HMB-45, and CD117 biomarkers. While the patient was treated with imatinib, the melanoma was too widespread and aggressive, leading to progression and ultimately death.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"17 1","pages":"235-241"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10294269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional Serrated Adenoma of the Ileum with Intussusception Successfully Treated with Laparoscopic Bowel Resection. 腹腔镜下肠切除术成功治疗传统的回肠锯齿状腺瘤伴肠套叠。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000529093

Ryo Nishide, Teppei Kamada, Junji Takahashi, Keigo Nakashima, Eisaku Ito, Yuichi Nakaseko, Norihiko Suzuki, Masashi Yoshida, Hironori Ohdaira, Yutaka Suzuki

{"title":"Traditional Serrated Adenoma of the Ileum with Intussusception Successfully Treated with Laparoscopic Bowel Resection.","authors":"Ryo Nishide, Teppei Kamada, Junji Takahashi, Keigo Nakashima, Eisaku Ito, Yuichi Nakaseko, Norihiko Suzuki, Masashi Yoshida, Hironori Ohdaira, Yutaka Suzuki","doi":"10.1159/000529093","DOIUrl":"https://doi.org/10.1159/000529093","url":null,"abstract":"The most common site of traditional serrated adenomas (TSA) is the area from the left colon to the rectum; however, there are few reports on TSA in the small intestine. Herein, we report a case of TSA of the ileum with intussusception that was diagnosed and successfully treated with laparoscopic bowel resection. The patient was a 29-year-old female with the chief complaint of recurrent abdominal pain and vomiting. Contrast-enhanced computed tomography showed a mass in the ileum and intussusception with the mass as the lead point. The patient was diagnosed with intussusception secondary to a small intestinal tumor. Due to the difficulty in endoscopic treatment resulting from the localization of the lesion, elective laparoscopic surgery was planned. Intra-abdominal examination revealed intussusception of the small intestine in the pelvic ileum, and an elastic soft mass 400 cm from the ligament of Treitz was identified at the lead point of intussusception. Partial laparoscopic resection of the small intestine was performed, with an operation time of 81 min, and a small amount of bleeding. The pathological diagnosis was TSA of the ileum, and the patient's postoperative course was good, with no complications. Seven months after the surgery, no recurrence of symptoms was observed. Therefore, from our case of TSA of the ileum with intussusception that was successfully treated with laparoscopic bowel resection, we conclude that when intussusception of the small intestine occurs, TSA of the ileum with malignant potential is possible, and early diagnosis by resection should be considered.","PeriodicalId":9614,"journal":{"name":"Case Reports in Gastroenterology","volume":"17 1","pages":"76-81"},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/b2/crg-2022-0017-0001-529093.PMC9906037.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10745662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Host in the Spectrum of Outcomes in Family Clusters of Hepatitis Infection: From Asymptomatic to Hepatocellular Carcinoma. 宿主在肝炎感染家族聚集性结局谱中的作用:从无症状到肝细胞癌。

IF 0.6

Case Reports in Gastroenterology Pub Date : 2023-01-01 DOI: 10.1159/000529153

Nicholas Noverati, Anh Nguyen, Divya Chalikonda, Dina Halegoua-DeMarzio, Hie-Won Hann

引用次数: 0