Annales d'endocrinologie最新文献

{"title":"Sexual behavior in male mice is impaired by an obesogenic-diabetogenic diet and worsened by exposure to a relevant environmental mixture of phthalates","authors":"Lina Mahiddine,&nbsp;Caroline Parmentier,&nbsp;Sakina Mhaouty-Kodja,&nbsp;Hélène Hardin-Pouzet","doi":"10.1016/j.ando.2025.101752","DOIUrl":"10.1016/j.ando.2025.101752","url":null,"abstract":"<div><h3>Introduction</h3><div>The decrease in male fertility observed since the beginning of the 20th century in Western countries could be linked to changes in diets and exposure to molecules from industry, such as endocrine disruptors and among them, phthalates.</div></div><div><h3>Materials and methods</h3><div>Modelling Western lifestyle, the combined effects of a high fat/high fructose diet (HFHF) and exposure to an environmental mixture of phthalates (mix) were evaluated on male murine sexual behavior. Four groups of adult male C57Bl/6<!--> <!-->J mice were exposed during 17 weeks to a control diet (CD), a control diet coupled with the mix (CDmix), an HFHF diet, and an HFHF diet coupled with the mix (HFHFmix).</div></div><div><h3>Results and discussion</h3><div>Both HFHF and HFHFmix diets induced metabolic alterations, reminiscent of a type 2 diabetes. The HFHFmix diet altered the efficiency of sexual behavior, with a dramatic decrease in the number of animals reaching ejaculation and a subsequent increase in mating latency. This impairment was far over than the effect of the mix treatment alone. HFHFmix effect was associated with a decrease in testicular, seminal glands and Tyson glands weights and a loss in discrimination toward female counterparts in an olfactory preference test. No effects were recorded on locomotion activity. The effect of the HFHFmix on the cellular and molecular markers of the preoptic area of the hypothalamus (mPOA), the main integrating center in the control of male sexual behavior, demonstrated an alteration in the neural network.</div></div><div><h3>Conclusion</h3><div>Thus, the synergistic effect of an HFHF diet and exposure to phthalates, at doses relevant for human exposure, on male sexual behavior, revealed a specific vulnerability of the central nervous system. This requires special attention in term of public health recommendations.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101752"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-müllerian hormone: A new diagnostic marker for polycystic ovary syndrome?","authors":"Myriam Baltagi,&nbsp;Marwa Chiboub,&nbsp;Mariem Adel,&nbsp;Marwa Abdennour,&nbsp;Radhouen Gharbi,&nbsp;Manel Jemel,&nbsp;Ines Kammoun","doi":"10.1016/j.ando.2025.101739","DOIUrl":"10.1016/j.ando.2025.101739","url":null,"abstract":"<div><h3>Introduction</h3><div>Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5–15% of women of reproductive age. Diagnosis based on the Rotterdam criteria includes ovarian ultrasound, which is operator-dependent and subject to several limitations. Anti-Müllerian hormone (AMH), produced by granulosa cells of antral follicles, is emerging as an alternative biomarker. This study aims to determine an optimal AMH diagnostic threshold for Tunisian women.</div></div><div><h3>Materials and methods</h3><div>This multicenter, cross-sectional case-control study included 31 PCOS patients diagnosed according to the Rotterdam criteria and 31 age- and BMI-matched controls. Serum AMH levels were measured using an electrochemiluminescence assay. Pelvic ultrasound was performed transabdominally and, when feasible, transvaginally or transrectally. Correlations between AMH, age, testosterone levels, and antral follicle count were assessed using linear regression analysis.</div></div><div><h3>Results and discussion</h3><div>The mean AMH level was 3.6 times higher in PCOS patients (7.69<!--> <!-->ng/mL) than in controls (2.12<!--> <!-->ng/mL; <em>P</em> &lt;10⁻³). A significant positive correlation was observed between AMH and antral follicle count (B<!--> <!-->=<!--> <!-->0.25; <em>P</em> &lt;10⁻³) as well as with testosterone levels (B<!--> <!-->=<!--> <!-->0.07; <em>P</em> &lt;10⁻³). A negative correlation with age (B<!--> <!-->=<!--> <!-->−0.15; <em>P</em> &lt;10⁻³) was also demonstrated. ROC curve analysis identified an optimal diagnostic threshold of 3.41<!--> <!-->ng/mL, with a sensitivity of 97% and a specificity of 90%.</div></div><div><h3>Conclusion and limitations</h3><div>AMH is a reliable biomarker for PCOS in hyperandrogenic Tunisian women, potentially replacing ovarian ultrasound when it is unavailable, inconclusive, or lacks an experienced operator. Study limitations include the absence of phenotype D in our cohort and the need for validation in larger populations.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101739"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kisspeptin system–physiology and clinical perspectives","authors":"Nikolay Stoynev ,&nbsp;Philip Kumanov","doi":"10.1016/j.ando.2025.101793","DOIUrl":"10.1016/j.ando.2025.101793","url":null,"abstract":"<div><h3>Purpose</h3><div>To summarize the state of knowledge on kisspeptin, a factor that alters the migration properties of some types of cancer cell and also plays an important role in the control of the reproductive axis.</div></div><div><h3>Methods</h3><div>PubMed search, identifying the most recent relevant information.</div></div><div><h3>Results</h3><div>This review describes the physiological aspects about the regulation of kisspeptin release and its place in the regulation of reproductive axis. Kisspeptin's role in puberty and its interaction with male and female reproductive axis are discussed along with potential clinical perspectives. Further analysis was made of the interaction of kisspeptin with centrally acting metabolic factors and on the presence of the kisspeptin system in some organs outside the reproductive tract: pancreas, liver, and adipose tissue. The kisspeptin system is a factor that alters the metastatic potential in various cancer types–malignant melanoma, breast cancer, colorectal cancer, gastric carcinoma, thyroid carcinoma, hepatocellular carcinoma, etc. Additionally, kisspeptin has also been reported to induce dormancy in already disseminated tumor cells, thus suppressing metastatic colonization in multiple organs.</div></div><div><h3>Conclusion</h3><div>The kisspeptin system could in future provide additional diagnostic tests and even therapeutic targets and procedures for the management of some reproductive disorders. As a factor involved in suppression of metastasis, it may in future have significant value for prognosis and/or follow-up in various cancer types.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101793"},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone, a double victim in metastatic catecholamine secreting tumors","authors":"Arnaud Jannin ,&nbsp;Marie-Hélène Vieillard ,&nbsp;George Lion ,&nbsp;Benjamin Chevalier ,&nbsp;Amandine Beron ,&nbsp;Marie-Christine Vantyghem ,&nbsp;Catherine Cardot-Bauters ,&nbsp;Roland Chapurlat ,&nbsp;Christine Do Cao ,&nbsp;Stéphanie Espiard","doi":"10.1016/j.ando.2025.101792","DOIUrl":"10.1016/j.ando.2025.101792","url":null,"abstract":"<div><h3>Introduction</h3><div>Benign catecholamine-secreting pheochromocytoma and paraganglioma (PPGL) can cause secondary osteoporosis. Metastatic PPGLs, often presenting with bone metastases, elevated catecholamine levels and persistent disease, may lead to more severe bone impact. We investigated bone density and quality in three cases of metastatic PPGL over long-term follow-up.</div></div><div><h3>Patients</h3><div>Two patients had paragangliomas: a 43-year-old with an <em>SDHB</em>-related abdominal paraganglioma secreting norepinephrine, and a 35-year-old with an aggressive <em>SDHA</em>-related paraganglioma secreting both norepinephrine and dopamine. The third patient, aged 50<!--> <!-->years, had a sporadic pheochromocytoma producing norepinephrine and dopamine. Bone mineral density (BMD) and quality were studied using dual-energy X-ray absorptiometry (DXA). The 43-year-old and 35-year-old patients exhibited lumbar and hip osteoporosis. The 43-year-old patient also showed changes in the trabecular bone score (TBS) and suffered from both osteoporotic and metastatic vertebral fractures. The 50-year-old patient had a mildly reduced hip T score but no TBS impairment. Additionally, the 35-year-old patient underwent high-resolution peripheral quantitative computed tomography (HR-pQCT), revealing a moderate decline in total BMD in the right tibia and reduced trabecular thickness in the left radius, although there were no vertebral fractures. This patient was treated shortly after diagnosis by bone resorption inhibitors, due to metastatic vertebral fractures.</div></div><div><h3>Conclusions</h3><div>Impaired bone density and quality, possibly related to long-term exposure to catecholamine excess, contribute to skeletal-related events in metastatic PPGL. Recognizing these complications is important for patient management.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101792"},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical phenotypes and genetic screening in hereditary primary hyperparathyroidism: A single-center case series","authors":"Yian Gu ,&nbsp;Yuanyuan Ye ,&nbsp;Ning Xu ,&nbsp;Lina Chang,&nbsp;Xin Wang,&nbsp;Yumeng Huang,&nbsp;Baoping Wang ,&nbsp;Ming Liu ,&nbsp;Qing He","doi":"10.1016/j.ando.2025.101791","DOIUrl":"10.1016/j.ando.2025.101791","url":null,"abstract":"<div><h3>Background</h3><div>Hereditary primary hyperparathyroidism (PHPT) is a monogenic autosomal disorder, constituting 5–10% of all PHPT cases. Data on hereditary PHPT in the Chinese population are scarce.</div></div><div><h3>Purpose</h3><div>This study aimed to delineate the etiology, phenotype, genotype, management, and prognosis of hereditary PHPT in Tianjin Medical University General Hospital, expanding the spectrum of pathogenic genes and evaluating the age-dependent penetrance of clinical phenotypes. Additionally, genotype-phenotype correlations were explored in multiple endocrine neoplasia type 1 (MEN1).</div></div><div><h3>Methods</h3><div>A retrospective analysis of medical records from January 1st, 2008 to July 31st, 2024 included clinical presentations, biochemical markers, imaging findings, and whole exome sequencing.</div></div><div><h3>Results</h3><div>The study comprised 73 cases. MEN1 was predominant (80.8%), followed by hyperparathyroidism-jaw-tumor syndrome (9.6%), familial hypocalciuric hypercalcemia (5.5%), MEN2A (2.7%), and familial isolated hyperparathyroidism (1.4%). The male:female sex ratio was 1:1.6. Thirty patients (41.1%) exhibited multiglandular parathyroid involvement. Genetic testing in 57 patients identified 12 novel mutations, with 70.2% harboring pathogenic or likely pathogenic variants. Mean age at initial presentation for PHPT mutation carriers was 42.0<!--> <!-->±<!--> <!-->14.5 years, with 64.3% penetrance by 45 years of age. No significant genotype-phenotype correlations were observed for <em>MEN1</em> mutations.</div></div><div><h3>Conclusion</h3><div>This case series provided insight into the clinical phenotypes and mutational spectrum of hereditary PHPT, emphasizing the role of genetic testing for subtype classification, complications monitoring, treatment guidance and family surveillance. Genetic testing is recommended for PHPT patients with early-onset, complex clinical presentations, multiglandular parathyroid involvement or family history.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101791"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOCAN-TUTHYREF guidelines. Locoregional therapies for locally advanced and/or metastatic thyroid cancer","authors":"Arnaud Jannin ,&nbsp;Alexandre Escande ,&nbsp;Dana Hartl ,&nbsp;Guillaume Louvel ,&nbsp;Ingrid Breuskin ,&nbsp;Françoise Borson-Chazot ,&nbsp;Julien Hadoux ,&nbsp;Livia Lamartina ,&nbsp;Christine Do Cao ,&nbsp;Frédéric Deschamps","doi":"10.1016/j.ando.2025.101790","DOIUrl":"10.1016/j.ando.2025.101790","url":null,"abstract":"<div><div>This article presents consensus recommendations by a multidisciplinary panel of endocrinologists, medical oncologists, pathologists, radiation oncologists, surgeons and nuclear medicine physicians. The recommendations specifically address iodine-refractory well-differentiated thyroid carcinoma and locally advanced and/or metastatic medullary thyroid carcinoma. Treatment algorithms based on risk–benefit assessments of various multimodal therapeutic approaches are proposed for each clinical scenario. Given the limited data available on the management of these rare but aggressive forms of thyroid cancer, these consensus recommendations provide essential guidance for multidisciplinary teams to ensure optimal care for patients with these complex thyroid carcinomas.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101790"},"PeriodicalIF":2.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal necrosis following thermal ablation of a thyroid toxic nodule: A case report","authors":"Adrien Ben Hamou ,&nbsp;Gilles Russ","doi":"10.1016/j.ando.2025.101789","DOIUrl":"10.1016/j.ando.2025.101789","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101789"},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOCAN TUTHYREF network consensus recommendations: Anaplastic thyroid cancer","authors":"Livia Lamartina ,&nbsp;Arnaud Jannin ,&nbsp;Myriam Decaussin-Petrucci ,&nbsp;Stéphane Bardet ,&nbsp;Alexandre Escande ,&nbsp;Renaud Ciappuccini ,&nbsp;Françoise Borson Chazot ,&nbsp;Abir Al Ghuzlan ,&nbsp;Christine Do Cao ,&nbsp;Julien Hadoux","doi":"10.1016/j.ando.2025.101788","DOIUrl":"10.1016/j.ando.2025.101788","url":null,"abstract":"<div><div>Anaplastic thyroid cancer is a rare and rapidly deadly disease. In case of clinical suspicion (rapid growth, stony neck mass), diagnostic work-up should be carried out as a matter of urgency to enable prompt treatment. Multidisciplinary assessment involving the patient's referring specialists, the support care team, and if necessary, a geriatric oncology specialist should be performed and must take account of disease extent, comorbidities, general health status and the patient's wishes. Patients and their families should receive realistic information about the prognosis; either active treatment in parallel to support care or exclusive palliative care can be recommended from the outset. Despite the dismal prognosis, recent advances in tumor molecular profiling and treatment with the advent of targeted treatment and immunotherapy hold out great promise for the future. This article summarizes the consensus recommendations on management of anaplastic thyroid cancers by the ENDOCAN TUTHYREF network, a rare-cancer network of the French National Institute for Cancer (INCa).</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101788"},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOCAN TUTHYREF network consensus recommendations: Refractory follicular-derived thyroid cancer","authors":"Christine Do Cao ,&nbsp;Yann Godbert ,&nbsp;Stéphane Bardet ,&nbsp;Francoise Borson-Chazot ,&nbsp;Myriam Decaussin-Petrucci ,&nbsp;Johanna Wassermann ,&nbsp;Alexandre Lugat ,&nbsp;Camila Nascimento ,&nbsp;Sophie Leboulleux ,&nbsp;Bérangère Narciso ,&nbsp;Arnaud Jannin ,&nbsp;Julien Hadoux ,&nbsp;Paul Schwartz ,&nbsp;Ségolène Hescot ,&nbsp;Camille Buffet ,&nbsp;Livia Lamartina ,&nbsp;the ENDOCAN-TUTHYREF network","doi":"10.1016/j.ando.2025.101735","DOIUrl":"10.1016/j.ando.2025.101735","url":null,"abstract":"<div><div>Radioactive-iodine-refractory differentiated thyroid cancer (RAIR DTC) represents 3–5% of follicular-derived DTCs, with approximately 200–300 new cases diagnosed annually in France. Median overall survival in the French RAIR DTC database is 9.5<!--> <!-->years, underscoring the importance of long-term support for caregivers and patients. To guide treatment decision-making, the French ENDOCAN TUTHYREF network has provided algorithms for RAIR DTC management, available at the TUTHYREF website. The present article summarizes these recent practical recommendations, focusing on 5 points. (1) RAIR DTC has long been defined by locally advanced disease not amenable to surgery or metastatic disease not fully responding to radioactive iodine (RAI) therapy, a definition that can be further refined considering prognostic factors. (2) Treatment should be tailored according to tumor burden and progression, with local treatments prioritized for non-progressive or slowly progressive disease. (3) Early tumor molecular testing should be performed to identify driver oncogenes such as BRAF mutation or RET/NTRK/ALK fusion, to optimize access to existing selective targeted therapies. (4) For symptomatic or progressive RAIR DTC, tyrosine multikinase inhibitors, such as sorafenib, lenvatinib or cabozantinib, are the standard therapies, but alternative and 2nd-line kinase inhibitors are also available. (5) Since most therapies are associated with common side-effects such as fatigue and cardiovascular, digestive and skin issues, preparing and monitoring patients for systemic therapy should include careful assessment of comorbidities, toxicity prevention and individual dose adjustment. Overall, management of RAIR DTC requires a multidisciplinary approach, with an emphasis on personalized treatment strategies and proactive therapeutic education.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101735"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taste and endocrine disruption","authors":"Marie-Chantal Canivenc-Lavier ,&nbsp;Wided Kouidhi ,&nbsp;Sofiane Boudalia ,&nbsp;Mireille Folia","doi":"10.1016/j.ando.2025.101768","DOIUrl":"10.1016/j.ando.2025.101768","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101768"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}