Annales d'endocrinologie最新文献

{"title":"Obesity and global warming: A two-way relationship?","authors":"André Scheen","doi":"10.1016/j.ando.2025.101783","DOIUrl":"10.1016/j.ando.2025.101783","url":null,"abstract":"<div><div>Our modern society has to face several health problems, among which climate change characterized by global warming and increased pollution and obesity epidemic and associated morbidities are prominent ones. Interestingly, several epidemiological studies argue for a closed connection between these two health concerns, in fact pointing out a bidirectional relationship. Global warming and its associated exposure to pollutants could contribute to weight gain through different mechanisms, including some endocrine disorders linked to adipocyte dysfunction (adiposopathy) and reduced thermogenesis, as well as a reluctance to physical activity in a hot ambient temperature. Conversely, obesity epidemic may play a role in global warming by an increased consumption of energetic ultra-processed foods and an enhanced energy waste for transportation, both leading to increased greenhouse gas emission. Thus, there is an urgent need for greater action to slow the process of global warming also to prevent harmful effects on health linked to obesity epidemic.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101783"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine-disrupting chemicals and reproductive health: With focus on the developmental window of susceptibility","authors":"Terje Svingen","doi":"10.1016/j.ando.2025.101787","DOIUrl":"10.1016/j.ando.2025.101787","url":null,"abstract":"<div><div>Sexual differentiation is highly dependent on the fetal hormonal environment, guiding sexual development and establishing the foundation for lifelong reproductive health. This short communication highlights critical windows of sex determination and differentiation, emphasizing the role of steroid sex hormones, alongside other factors, in orchestrating these processes in early life. Growing evidence suggests that endocrine-disrupting chemicals (EDCs) can disrupt these tightly regulated pathways, leading to developmental disturbances that manifest as reproductive disorders at birth or later in life. In males, disrupted androgen signaling during fetal development is linked to hypospadias, cryptorchidism, reduced fertility, and testicular cancer, while in females, EDC exposure may contribute to altered ovarian function, early puberty, polycystic ovary syndrome (PCOS), and infertility. By illustrating how EDCs can interfere with sexual development, this brief review underscores the need for further research and regulatory measures to mitigate their impact on human health.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101787"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine disrupting chemicals alter neuronal circuits controlling reproduction and appetite","authors":"Anneline Pinson ,&nbsp;Chloé Glachet ,&nbsp;Charlotte Jacquinet ,&nbsp;Elena Sevrin ,&nbsp;Marie-Azélie Moralia ,&nbsp;Anne-Simone Parent","doi":"10.1016/j.ando.2025.101781","DOIUrl":"10.1016/j.ando.2025.101781","url":null,"abstract":"<div><div>Exposure to endocrine disrupting chemicals during critical periods of development can result in detrimental long-term health consequences. The hypothalamus is extremely sensitive to endocrine disrupting chemicals, which could participate to the increase in metabolic and reproduction related diseases. We propose the concept according to which exposure to low levels of endocrine disrupting chemicals induces developmental and transgenerational alterations of sexual maturation and energy balance through reprograming of the hypothalamus.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101781"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic hormones, artificial sweeteners and the development of hypothalamic circuits controlling appetite","authors":"Sebastien G. Bouret","doi":"10.1016/j.ando.2025.101767","DOIUrl":"10.1016/j.ando.2025.101767","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101767"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rachel Carson and the silent spring: A forgotten message?","authors":"Haroun Jedidi","doi":"10.1016/j.ando.2025.101777","DOIUrl":"10.1016/j.ando.2025.101777","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101777"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes from plastics: Role of endocrine disruptors in β-cell physiology","authors":"Angel Nadal","doi":"10.1016/j.ando.2025.101780","DOIUrl":"10.1016/j.ando.2025.101780","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101780"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving from research tools to risk management tools in endocrine disruptors: Validation","authors":"Phillipe Hubert ,&nbsp;Torben Österlund ,&nbsp;Pauline Lelandais ,&nbsp;K. Schlüppmann ,&nbsp;Nathalie Belot ,&nbsp;Andrea Rivero-Arze","doi":"10.1016/j.ando.2025.101776","DOIUrl":"10.1016/j.ando.2025.101776","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101776"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key data from the 2024 European Thyroid Association annual congress: What's new in aggressive thyroid carcinoma?","authors":"Louis Schubert ,&nbsp;Magalie Haissaguerre ,&nbsp;Philippe Caron ,&nbsp;Lionel Groussin","doi":"10.1016/j.ando.2025.101734","DOIUrl":"10.1016/j.ando.2025.101734","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101734"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption of biological communication","authors":"Robert Barouki ,&nbsp;Etienne Blanc ,&nbsp;Xavier Coumoul","doi":"10.1016/j.ando.2025.101766","DOIUrl":"10.1016/j.ando.2025.101766","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101766"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crisis on the Planet of the Apes–Plastic, the new threat?","authors":"Sabrina Krief ,&nbsp;Petra Spirhanzlova ,&nbsp;Jean-Baptiste Fini","doi":"10.1016/j.ando.2025.101778","DOIUrl":"10.1016/j.ando.2025.101778","url":null,"abstract":"<div><h3>Introduction</h3><div>Chimpanzees, our closest relatives, are threatened with extinction by poaching, zoonoses, fragmentation and the destruction of their natural habitat, the tropical forests. The degradation of their habitat due to agricultural expansion and the development of road infrastructures expose them to new risks including pollution.</div></div><div><h3>Material and methods</h3><div>Kibale National Park (Uganda) covers 800<!--> <!-->km² of mid-altitude forest surrounded by agricultural areas. In the northern part of this protected area, 80% of the perimeter of the Sebitoli chimpanzees’ territory is surrounded by human activities (tea, maize and banana plantations, etc.) and crossed by an asphalt road with heavy traffic. In order to study the effects of anthropization on the closest primates to our species, these chimpanzees have been habituated to humans, observed and photographed, and a non-invasive health monitoring has been carried out since 2008. Samples of soil, sediment, water, fish, exhaust gases have been tested for presence of chemicals and plastic bottles along the road were collected. Chimpanzee hair from their nests and urine were also analyzed to assess chimpanzees’ exposure to different types of pollution.</div></div><div><h3>Results</h3><div>Facial congenital deformities and disorders of the female sexual cycle have been observed in Sebitoli chimpanzees. Three successive campaigns showed the presence of a cocktail of chemical pollutants in the rivers that cross their territory. Biological tests of this water show endocrine disruption effects on the thyroid, estrogenic and androgenic axes. Analysis of the chimpanzees’ hair showed the presence of 60 pesticide-type molecules, as well as bisphenol A and S, monomers of polycarbonate plastic compounds. Markers of oxidative stress, in particular DNA degradation, were detected in the urine of chimpanzees that frequented the border and consumed maize coated with neonicotinoids.</div></div><div><h3>Conclusion</h3><div>At the heart of tropical forests, wild chimpanzees are exposed to environmental pollution from nearby agricultural areas and the thousands of soda bottles discarded along roadside. The genotoxic oxidative stress, facial malformations and reproductive disorders detected in this community are an alarming signal not only for this species, which is already highly threatened by human activities, but also for our own species. Our research will help to clarify the etiology of these disorders in this sentinel species for our health and that of our environment, and in particular to gain a better understanding of the risks associated with plastics.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101778"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}