Annales d'endocrinologie最新文献

Can standard CGM data be used to identify an HNF1B MODY-5 glucotype? Insights from a clinical case 标准 CGM 数据可用于识别 HNF1B MODY-5 葡萄糖型吗？一个临床病例的启示。

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-04-01 DOI: 10.1016/j.ando.2024.10.002

Philippe Oriot , Noemie Klipper dit kurz , Michel P. Hermans

引用次数: 0

Body composition in a pediatric population with type-1 diabetes – The importance of planned physical exercise 1 型糖尿病患儿的身体成分--有计划的体育锻炼的重要性。

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-04-01 DOI: 10.1016/j.ando.2024.09.004

Maria Adriana Rangel , Rita Calejo , Vilma Lopes , Rosa Arménia Campos , Ana Luísa Leite

{"title":"Body composition in a pediatric population with type-1 diabetes – The importance of planned physical exercise","authors":"Maria Adriana Rangel , Rita Calejo , Vilma Lopes , Rosa Arménia Campos , Ana Luísa Leite","doi":"10.1016/j.ando.2024.09.004","DOIUrl":"10.1016/j.ando.2024.09.004","url":null,"abstract":"<div><h3>Objective and methods</h3><div>This study aimed to assess the body composition of pediatric patients with type-1 diabetes (T1D) in a Portuguese pediatric endocrinology/diabetic clinic, using the InBody 570 bioimpedance system. Preschool children (<6 years) and those recently diagnosed (<6 months) were excluded.</div></div><div><h3>Results</h3><div>The study included 78 patients (53% female). Median age at assessment was 14 years, with 81% pubertal children. Eighty-seven percent were using continuous subcutaneous insulin infusion (CSII), 25% with an automated closed-loop model. Median HbA1c was 7.3%. Most had an adequate body mass index (BMI) standard deviation score (62%) and 48% engaged in regular physical exercise (PE) outside of school. Median percentage body fat (PBF) was 21.5% and was abnormal in 48%, with median visceral adiposity of 4. Despite adequate BMI, 11% had excessive PBF. PBF was significantly associated with visceral fat (r=0.79; <em>P</em>  <0.001) and PE performed out of school (<em>P</em>  =0.005), lower visceral fat (<em>P</em>  =0.006).</div></div><div><h3>Conclusion</h3><div>Engaging in physical exercise out of school correlated significantly with improved body composition, characterized by reduced PBF and diminished visceral adiposity. Considering the known benefits of physical exercise for metabolic and glycemic control, this study highlights the importance of promoting regular physical exercise in T1D patients.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 2","pages":"Article 101670"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observational study of demographics and glycemia control in inpatients with type 2 diabetes: Challenges and clinical implications

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-20 DOI: 10.1016/j.ando.2025.101720

Madleen Lemaitre , Paul Quindroit , Camille Frévent , Pierre Balayé , Anne Vambergue , Jean-Baptiste Beuscart

{"title":"Observational study of demographics and glycemia control in inpatients with type 2 diabetes: Challenges and clinical implications","authors":"Madleen Lemaitre , Paul Quindroit , Camille Frévent , Pierre Balayé , Anne Vambergue , Jean-Baptiste Beuscart","doi":"10.1016/j.ando.2025.101720","DOIUrl":"10.1016/j.ando.2025.101720","url":null,"abstract":"<div><h3>Introduction</h3><div>The objective of the present study was to evaluate the clinical, metabolic control and treatment profiles of patients with type 2 diabetes admitted to a university hospital.</div></div><div><h3>Research design and methods</h3><div>The study analyzed 5 years of data (2015–2020) in the University Hospital of Lille, France, focusing on stays lasting 48hours or more for type 2 diabetes patients aged 55 or over. Stays in diabetology, outpatient and day hospital wards were excluded.</div></div><div><h3>Results</h3><div>Among 2,216,834 stays during the study period, 55,292 (30%) involved diabetic patients. 50,205 (90.2%) concerned wards other than the diabetology department, and 42,865 (85.4%) of these stays involved patients with type 2 diabetes. Median [interquartile range] age was 70 years [range, 64, 79], median glycated hemoglobin level 6.8% [range, 6.1, 7.8], and median hospital stay 8 days [range, 4.3, 15.1]. A total of 55.3% of the patients treated with insulin, 40.5% with oral antidiabetic drugs, 12.5% a combination of the two, and 16.5% with lifestyle and dietary measures alone. Only 13,640 (31.8%) stays had data for glycated hemoglobin, and a third of these revealed chronic metabolic imbalance. Data on glycated hemoglobin were available for only 43.5% by patients on insulin, 51.1% for patients taking 3 oral antidiabetic drugs, and 54.9% for patients taking 4 oral antidiabetic drugs.</div></div><div><h3>Conclusion</h3><div>It is necessary to optimize the management of people with diabetes admitted outside diabetes wards, ensuring at least HbA1c evaluation. Despite the use of various therapies, including hypoglycemic agents, few patients receive appropriate metabolic balance assessments with HbA1c as gold-standard. Optimizing collaboration between clinicians and use of clinical decision support system alerts can help in at-risk situations.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101720"},"PeriodicalIF":2.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal steroids: New assays, new methods

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-15 DOI: 10.1016/j.ando.2025.101709

Lucas Bouys , Fidéline Bonnet-Serrano , Guillaume Assié

引用次数: 0

New treatments for acromegaly: Is a revolution underway?

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-15 DOI: 10.1016/j.ando.2025.101710

Justine Cristante , Frédéric Castinetti

引用次数: 0

Obesity and its treatment: Toward new approaches

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-15 DOI: 10.1016/j.ando.2025.101712

Bérénice Segrestin , Blandine Gatta Cherifi

{"title":"Obesity and its treatment: Toward new approaches","authors":"Bérénice Segrestin , Blandine Gatta Cherifi","doi":"10.1016/j.ando.2025.101712","DOIUrl":"10.1016/j.ando.2025.101712","url":null,"abstract":"<div><div>Obesity has until now been defined in terms of body mass index, a parameter which lacks sensitivity. The definition rather needs to take account of the pathophysiology and impact of the mechanical, metabolic and psychological complications associated with excess adiposity, as proposed by the French Health Authority in 2022. Initial phenotyping of pathophysiological determinants and complications make it possible to precisely define treatment objectives and the means used to achieve them. For example, excess adiposity is associated with hypervolemia, which increases the risk of heart failure independently of classic cardiovascular risk factors, due in particular to myocardial remodeling and diastolic dysfunction. In this indication, SGLT2 (sodium/glucose cotransporter 2) inhibitors may be relevant. A global approach, involving assessment of eating behavior and sensations, energy expenditure and emotional eating, enables us to identify drug treatments suited to each profile. Obesity is a recurrent pathology requiring the development of new combined or sequential drug treatments. Currently under development, inhibitors of the myostatin/activin A pathway conserve lean body mass during weight loss, a crucial factor in limiting weight regain and maintaining functional capacity. Beyond medical or surgical approaches to obesity, lifelong lifestyle interventions are central to improving quality of life and limiting the risks associated with excess adiposity.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 2","pages":"Article 101712"},"PeriodicalIF":2.9,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on management of cytologically indeterminate thyroid nodules

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-15 DOI: 10.1016/j.ando.2025.101711

Malanie Roy , Cécile Ghander , Claude Bigorgne , Mathilde Brière , Gabrielle Deniziaut , François Ansart , Charlotte Lussey-Lepoutre , Camille Buffet

{"title":"An update on management of cytologically indeterminate thyroid nodules","authors":"Malanie Roy , Cécile Ghander , Claude Bigorgne , Mathilde Brière , Gabrielle Deniziaut , François Ansart , Charlotte Lussey-Lepoutre , Camille Buffet","doi":"10.1016/j.ando.2025.101711","DOIUrl":"10.1016/j.ando.2025.101711","url":null,"abstract":"<div><div>Thyroid nodules are common, but only 5–15% are cancerous. Fine-needle aspiration cytology is the gold-standard examination for determining the nature of a thyroid nodule, with results reported according to the Bethesda International Classification as updated in 2023. However, 20–30% of nodules are cytologically indeterminate. The challenge here is to avoid unnecessary diagnostic surgery, since 70% of these nodules are benign, although thyroid cancer remains a possibility. Nodule size, growth rate and ultrasonographic or elastographic characteristics can guide management, but have not been shown to have robust diagnostic performance. Thyroid scintigraphy with iodine-123, MIBI and 18F-FDG PET/CT have shown some usefulness, but their efficacy and cost–benefit ratio remain debatable. Artificial intelligence should help clarify the diagnosis of thyroid nodules, but these approaches have yet to be validated in routine clinical practice. Molecular tests performed during aspiration of a thyroid nodule, marketed mainly in the United States, offer robust prospects, as they show good negative predictive values to rule out malignancy when the test is negative, but their high cost limits widespread use in Europe. In France, the development of molecular tests for research purposes is being encouraged. In conclusion, although progress has been made, management of indeterminate thyroid nodules remains complex and relies on a medical decision shared with the patient, pending validation of new diagnostic tools.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 2","pages":"Article 101711"},"PeriodicalIF":2.9,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key data from the 2024 European Thyroid Association annual meeting: Differentiated thyroid carcinoma. What's new in low-risk thyroid carcinoma? Update after the 2024 ETA congress

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-03 DOI: 10.1016/j.ando.2025.101707

Magalie Haissaguerre , Lionel Groussin , Livia Lamartina , Camille Buffet , Philippe Caron

引用次数: 0

Chapter 2: Primary Hyperparathyroidism: diagnosis 第二章：原发性甲状旁腺功能亢进的诊断。

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-01 DOI: 10.1016/j.ando.2025.101691

Benjamin Bouillet , Jean-Philippe Bertocchio , Claire Nominé-Criqui , Véronique Kerlan

{"title":"Chapter 2: Primary Hyperparathyroidism: diagnosis","authors":"Benjamin Bouillet , Jean-Philippe Bertocchio , Claire Nominé-Criqui , Véronique Kerlan","doi":"10.1016/j.ando.2025.101691","DOIUrl":"10.1016/j.ando.2025.101691","url":null,"abstract":"<div><div>Primary hyperparathyroidism is now predominantly an asymptomatic pathology, as blood calcium assay has become systematic. Diagnosis therefore requires screening for target organ damage when this is not already indicative of primary hyperparathyroidism. Classical clinical manifestations include bone, kidney and muscle signs, and are characterized by reversibility after parathyroid surgery. Their presence requires blood calcium assay. Non-classical manifestations include cardiovascular, digestive and neuropsychological signs, which are not known to be reversible after surgery. Positive diagnosis is biological, based on a parathyroid hormone value that is inappropriate to the blood calcium value. The typical form combines hypercalcemia, elevated parathyroid hormone and increased calciuria or calcium excretion fraction. Atypical forms combine either hypercalcemia and normal parathyroid hormone level, or normal calcemia with increased parathyroid hormone level, not necessarily secondary to another cause, such as 25(OH) vitamin D deficiency. The oral calcium loading test and the Pro-FHH score are contributive to diagnosis in atypical forms.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 1","pages":"Article 101691"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chapter 0: Introduction to the consensus on primary hyperparathyroidism from the French Society of Endocrinology, French speaking Association of Endocrine Surgery and French Society of Nuclear Medicine 第0章：介绍了法国内分泌学会、法国内分泌外科学会和法国核医学学会对原发性甲状旁腺功能亢进的共识。

IF 2.9 3区医学

Annales d'endocrinologie Pub Date : 2025-02-01 DOI: 10.1016/j.ando.2025.101689

Peter Kamenicky , Eric Mirallie , Elif Hindie , Marie-Christine Vantyghem , Laurent Brunaud

{"title":"Chapter 0: Introduction to the consensus on primary hyperparathyroidism from the French Society of Endocrinology, French speaking Association of Endocrine Surgery and French Society of Nuclear Medicine","authors":"Peter Kamenicky , Eric Mirallie , Elif Hindie , Marie-Christine Vantyghem , Laurent Brunaud","doi":"10.1016/j.ando.2025.101689","DOIUrl":"10.1016/j.ando.2025.101689","url":null,"abstract":"<div><div>This consensus on primary hyperparathyroidism, drawn up under the aegises of the French Society of Endocrinology (SFE), French speaking Association of Endocrine Surgery (AFCE) and French Society of Nuclear Medicine (SFMN), provides an update on positive, etiological and differential diagnosis and treatment in primary hyperparathyroidism. These recommendations take account of recent increase in the prevalence of primary hyperparathyroidism, due to 1. More systematic routine measurement of blood calcium and improved quality of parathyroid hormone assays, 2. Developments in genetics, 3. The steady increase in life expectancy, affecting the long-term consequences of asymptomatic hyperparathyroidism, 4. Advances in parathyroid imaging, 5. Targeted surgical management, 6. Therapeutic alternatives when surgery is contraindicated, and 7. Better understanding of pathophysiological mechanisms and hence of differential diagnoses, and in particular secondary and tertiary hyperparathyroidism. The consensus is published in French on the Société Française d’Endocrinologie website (<span><span>https://www.sfendocrino.org/</span><svg><path></path></svg></span>), and in English in the <em>Annales d’Endocrinologie</em>/<em>Annals of Endocrinology</em> and the <em>Journal of Visceral Surgery</em>. A summary for general practitioners will be made available on the French Health Authority (HAS) website (<span><span>https://www.has-sante.fr/</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 1","pages":"Article 101689"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0