Annales d'endocrinologie最新文献

{"title":"Differences in clinical, hormonal and radiological profile between Cushing's disease and ectopic Cushing's syndrome. Series of 37 cases","authors":"Carmen Gándara Gutiérrez ,&nbsp;Mario Alfredo Saavedra Vásquez ,&nbsp;Eider Pascual-Corrales ,&nbsp;Víctor Rodríguez Berrocal ,&nbsp;Manuel Luque-Ramírez ,&nbsp;Marta Araujo-Castro","doi":"10.1016/j.ando.2025.101802","DOIUrl":"10.1016/j.ando.2025.101802","url":null,"abstract":"<div><h3>Introduction</h3><div>ACTH-dependent Cushing's syndrome (CS) is a diagnostic challenge. Clinical variability and difficult interpretation of diagnostic tests delay diagnosis and increase morbidity.</div></div><div><h3>Objective</h3><div>To describe clinical, biochemical and radiological differences in patients with ACTH-dependent CS, with the aim of determining the variables that may help to non-invasively differentiate between Cushing's disease (CD) and ectopic CS (ECS).</div></div><div><h3>Methods</h3><div>A retrospective study included patients with ACTH-dependent CS followed at the Ramón y Cajal University Hospital between 2018 and 2023.</div></div><div><h3>Results</h3><div>Twenty-eight patients with CD and 9 with ECS were included. Urinary free cortisol (UFC) levels presented an area under the ROC curve (AUC) of 0.812 (95% CI, 0.607–1.000) to differentiate between the two entities. UFC<!--> <!-->&gt;<!--> <!-->4.2 times the upper limit of normal showed 62.5% sensitivity and 90.9% specificity for diagnosis of ECS. The differential diagnostic accuracy of potassium level between ECS and CD was 82% (95% CI, 0.598–1.000). The combination of UFC and potassium values increased diagnostic accuracy to 85% (95% CI, 0.586–1.000). 55.6% of patients with ECS presented metabolic alkalosis, compared to 2.8% of those with CD (<em>P</em> <!-->=<!--> <!-->0.001). Pituitary adenoma size presented an AUC of 0.844 (95% CI, 0.59–1.000) for diagnosis of CD. Size<!--> <!-->≥<!--> <!-->4.5<!--> <!-->mm presented 93.8% sensitivity and 50% specificity for the diagnosis of CD.</div></div><div><h3>Conclusions</h3><div>UFC, hypokalemia, metabolic alkalosis and pituitary adenoma size are the non-invasive parameters most accurately differentiating between CD and ECS.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 5","pages":"Article 101802"},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraben exposure profiles in pregnant women and association with changes in thyroid hormone levels","authors":"Abderrezak Khelfi ,&nbsp;Asma Idjeraoui ,&nbsp;Hadjer Ouarzidini ,&nbsp;Kahina Aksas ,&nbsp;Mohamed Makrelouf ,&nbsp;Mohamed Cherifi ,&nbsp;Mohamed Azzouz","doi":"10.1016/j.ando.2025.101801","DOIUrl":"10.1016/j.ando.2025.101801","url":null,"abstract":"<div><div>Parabens are widely suspected to be endocrine disruptors. Exposure during pregnancy may interfere with thyroid hormone homeostasis, resulting in adverse effects on neurodevelopment and fetal growth. This study aimed to assess pregnant women's exposure to parabens and possible associations with changes in thyroid hormone levels during pregnancy. Links between exposure sources and endogenous paraben concentrations were also investigated. This descriptive study included 384 pregnant women. Thyroid hormones and thyroid-stimulating hormone (TSH) were measured on electrochemiluminescence. Parabens (methylparaben [MP], ethylparaben [EP] and propylparaben [PP]) were detected on LC-MS/MS. Parabens were found in almost all pregnant women (MP: 96.9%; EP: 89.3%; PP: 94.5%), at varying ranges of μg/g creatinine (MP: 36.633<!--> <!-->±<!--> <!-->39.849; EP: 9.721<!--> <!-->±<!--> <!-->15.655; PP: 22.109<!--> <!-->±<!--> <!-->20.722). There were significant negative associations between urinary concentrations of PP and plasma levels of TSH and free thyroxine (FT4). Analysis of exposure sources revealed significant associations of urinary levels of EP with exposure to facial care products and sunscreens. This research highlights the alarming rate of exposure to parabens, which may have deleterious effects on thyroid hormone levels in pregnant women, with consequent repercussions on fetal neural development.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 5","pages":"Article 101801"},"PeriodicalIF":2.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian stromal hyperthecosis: An underestimated virilizing disorder in postmenopausal women","authors":"Ons Boudaouara ,&nbsp;Anis Sellami ,&nbsp;Pascal Roger","doi":"10.1016/j.ando.2025.101800","DOIUrl":"10.1016/j.ando.2025.101800","url":null,"abstract":"<div><div>Ovarian stromal hyperthecosis is an uncommon non-neoplastic ovarian disorder resulting in excessive androgen production and virilization. We report two cases of ovarian stromal hyperthecosis in postmenopausal women. Both complained of symptoms of virilization, with high serum testosterone levels. Pelvic imaging showed homogenous ovaries of normal or increased size. Ovarian venous sampling was performed in one patient and found a left-to-right androgen concentration gradient. Both women underwent first-line bilateral oophorectomy. Pathology found bilateral ovarian stromal hyperthecosis. Postoperatively, clinical and biological hyperandrogenism resolved within few months. Hyperthecosis is a benign virilizing condition almost always involving both ovaries. Numerous virilizing diseases, and especially androgen-producing neoplasms, have to be ruled out before considering this diagnosis.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 5","pages":"Article 101800"},"PeriodicalIF":2.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of moderate iodine deficiency on embryonic exposure to a mix of endocrine disruptors","authors":"Patricia Rannaud-Bartaire ,&nbsp;Sébastien Le-Mével ,&nbsp;Manon Bonnelle ,&nbsp;Jean-Baptiste Fini","doi":"10.1016/j.ando.2025.101756","DOIUrl":"10.1016/j.ando.2025.101756","url":null,"abstract":"<div><h3>Objective</h3><div>We tested the hypothesis that moderate iodine deficiency (still frequent despite iodine supplementation of table salt since the 1970s in France) during gestation aggravates the action of endocrine disruptors (EDs) on thyroid hormone (TH) function. Some EDs interact at various levels with the thyroid system, inducing compensatory TH production, drawing on iodine reserves.</div></div><div><h3>Material and method</h3><div>Xenopus tropicalis embryos were exposed from cell-stage 2 to end of neurogenesis to a mix of 14 EDs previously shown to impact TH, cell proliferation and neuron differentiation. The embryos were further exposed to sodium perchlorate 20<!--> <!-->mg/L in the fluid, to mimic moderate iodine deficiency. We assessed cerebral gene expression on qPCR, proliferation/apoptosis ratio on brain immunohistochemistry, and behavioral impact on tadpole motion.</div></div><div><h3>Results</h3><div>Expression of key TH axis genes was more severely inhibited under moderate iodine deficiency combined to EDs than under deficiency or EDs alone. Combined exposure also impaired tadpole motion and brain-cell proliferation.</div></div><div><h3>Discussion</h3><div>Even moderate iodine deficiency can aggravate the effects of a pollutant mix on the thyroid axis during critical phases and notably during embryonic development. These results suggest that it is important to limit exposure to chemicals, and also to take account of all components of the exposome that are liable to aggravate impact.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101756"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of ante-natal exposure to a mixture of endocrine disruptors on cognitive and neuromotor functions in preschool children","authors":"Christophe Barrea ,&nbsp;Patrice Dufour ,&nbsp;Pirard Catherine ,&nbsp;Corinne Charlier ,&nbsp;Fanny Brévers ,&nbsp;Anne-Simone Parent ,&nbsp;Laurence Rousselle","doi":"10.1016/j.ando.2025.101740","DOIUrl":"10.1016/j.ando.2025.101740","url":null,"abstract":"<div><h3>Objective</h3><div>The effects of prenatal exposure to endocrine-disrupting chemicals (EDCs) on neurodevelopment remain inconsistent, and few studies have specifically examined cognitive processes. Additionally, toxicants are often analyzed individually, without considering their combined effects. This study aimed to investigate the impact of prenatal exposure to a mixture of persistent organic pollutants (POPs) on neuromotor and cognitive development in preschool-aged children.</div></div><div><h3>Methods</h3><div>Between 2014 and 2016, 62 children were recruited into a longitudinal cohort study. Cord serum samples were analyzed for one organochlorine pesticide, four polychlorinated biphenyls (PCBs), and seven perfluoroalkyl substances (PFASs).</div><div>At six years of age, children underwent neuropsychological assessments evaluating intelligence, attention, memory, and executive functioning, as well as standardized tests for motor skills, language, and arithmetic abilities. Associations between POP mixtures and these outcomes were analyzed using the principal component approach and weighted quantile sum regression, accounting for sex differences.</div></div><div><h3>Results</h3><div>Higher prenatal exposure to POP mixtures was significantly associated with lower attentional, neuromotor, and language scores when boys and girls were analyzed together.</div><div>In sex-stratified analyses, negative associations with attentional and neuromotor functions remained significant but were observed only in boys. Additionally, boys with higher prenatal exposure to POP mixtures exhibited lower scores in full-scale intelligence quotient (FSIQ), fluid reasoning index, working memory, and planning abilities. In contrast, prenatal exposure to a mixture of EDCs in girls was associated with reduced behavioral regulation, particularly inhibition control. Regarding language development, exposure to POP mixtures was associated with lower receptive language abilities in boys, whereas expressive language was more affected in girls. No significant association was found with arithmetic abilities.</div></div><div><h3>Conclusion</h3><div>These findings support negative associations between prenatal exposure to a mixture of endocrine disruptors and specific cognitive functions in children. Our study highlights a sex-specific effect, contributing to a better understanding of trends described in the literature.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101740"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabete and Covid-19: Factors for complications and death. A 60-case series","authors":"Marwa Sassioui,&nbsp;Saloua Elamari,&nbsp;Soukaina Laidi,&nbsp;Imane Motaib,&nbsp;Asma Chadli,&nbsp;Marouane Fatima","doi":"10.1016/j.ando.2025.101759","DOIUrl":"10.1016/j.ando.2025.101759","url":null,"abstract":"<div><h3>Introduction</h3><div>Covid-19, caused by SARS-CoV-2, is a life-threatening infection. Diabetes is a major comorbidity that increases the risk of complications and death. The present study describes the phenotype of diabetic patients with Covid-19 and identifies factors for severity.</div></div><div><h3>Materials and methods</h3><div>The present single-center retrospective study focused on diabetic patients with Covid-19 referred to the Mohamed VI International University Hospital between January 1 and December 21, 2021. We compared phenotypic features between groups with and without complications. Multivariate logistic regression was applied to assess risk and identify predictive factors for complications and death.</div></div><div><h3>Results</h3><div>Sixty patients were included: 63.33% male; median age, 67 years. At least 1 complication occurred in 41.67% of patients, including death in 21.7%. On univariate analysis, variables significantly associated with risk of complications comprised: male gender, overweight/obesity, high rate of pulmonary lesions on CT, low glomerular filtration rate, and mean daily glycemia &gt;2.5<!--> <!-->g/L; variables inversely associated with risk of complications comprised insulin and saturation elevation. Only male gender, overweight/obesity, hyperleukocytosis and mean glycemia for the first 4 days remained significant on multivariate logistic regression.</div></div><div><h3>Conclusion</h3><div>Male diabetic patients with high body-mass index, admitted with hyperleukocytosis and persistent glycemia elevation during hospital stay are more likely to progress toward more severe Covid-19, with poorer prognosis. They require specific care during hospital stay.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101759"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histomorphometric study of thyroid tissue in juvenile rats exposed to 5G electromagnetic fields","authors":"Mathilde Ramelet ,&nbsp;Lise Ronger ,&nbsp;Abdallah Al-Salameh ,&nbsp;Amandine Pelletier ,&nbsp;Rachel Desailloud ,&nbsp;Chandreshwar Seewooruttun","doi":"10.1016/j.ando.2025.101755","DOIUrl":"10.1016/j.ando.2025.101755","url":null,"abstract":"<div><h3>Introduction</h3><div>5G network deployment raises the issue of the health impact of these electromagnetic fields. Their effect on thermal regulation is of a “cold reesponse” type. In rats exposed to 900<!--> <!-->MHz, vasoconstriction was induced in the tail, with behavioral preference for warmer compartments. The hypothalamo-pituitary-thyroid axis is involved in thermogenesis: in response to cold, thyroid activity increases, stimulating heat production.</div></div><div><h3>Objective</h3><div>To assess thyroid activity after 5G exposure.</div></div><div><h3>Method</h3><div>Ten 3-week-old male Wistar rats were randomized between 2 weeks’ 5G exposure at 3.5<!--> <!-->GHz and 1.5<!--> <!-->V/m (5G group; <em>n</em> <!-->=<!--> <!-->5) and no exposure (controls; <em>n</em> <!-->=<!--> <!-->5). After sacrifice, the thyroid gland was harvested for histomorphometry. Thyroid follicle and colloid areas were measured and the thyroid activation index (TAI: ratio of follicle to colloid area) was assessed.</div></div><div><h3>Results</h3><div>Follicle and colloid areas were significantly greater in 5G (2729<!--> <!-->μm² vs 2444<!--> <!-->μm², <em>P</em> <!-->=<!--> <!-->0.0063; and 1317<!--> <!-->μm² vs 1015<!--> <!-->μm², <em>P</em> <!-->=<!--> <!-->0.0027 respectively) and TAI was significantly lower (5.62 vs 7.07, <em>P</em> &lt;0.001). These results indicate thyroid hypoactivity.</div></div><div><h3>Discussion</h3><div>There was a 5G effect, with histomorphometry demonstrating thyroid hypoactivity, suggesting mechanisms different from those underlying cold response. Impact of electromagnetic fields on thyroid function was previously reported, but results were heterogeneous and discordant depending on the type of exposure.</div></div><div><h3>Conclusion</h3><div>TSH and thyroid hormone assays are underway to reinforce assessment of thyroid function. Further studies are needed to explore the underlying mechanisms.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101755"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peppermint: Can it influence the clinico-biological phenotype of women with PCOS?","authors":"Syrine Trabelsi,&nbsp;Maroua Chiboub,&nbsp;Mariem Adel,&nbsp;Amel Rekik,&nbsp;Manel Jemel,&nbsp;Ines Kammoun","doi":"10.1016/j.ando.2025.101761","DOIUrl":"10.1016/j.ando.2025.101761","url":null,"abstract":"<div><h3>Introduction</h3><div>Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of childbearing age, affecting up to 20% of women worldwide. This syndrome is characterized by a combination of symptoms, including menstrual disorders and clinical and/or biological hyperandrogenism.</div></div><div><h3>Methods</h3><div>We conducted a prospective interventional study that included 20 patients followed for PCOS at the Endocrinology B Department of the National Institute of Nutrition and Food Technology. All our patients received peppermint infusion sachets containing 3<!--> <!-->g per sachet twice a day for 5 days a week for five weeks.</div></div><div><h3>Results</h3><div>The median age was 27 years. All patients initially presented with hirsutism, with a significant improvement in the Ferriman-Gallwey score (<em>P</em> &lt;<!--> <!-->0.01) post-intervention. Menstrual cycle disorders were significantly reduced (<em>P</em> &lt;<!--> <!-->0.05). A significant reduction in weight (<em>P</em> <!-->=<!--> <!-->0.029) and BMI (<em>P</em> <!-->=<!--> <!-->0.026) was noted despite no change in eating behavior. Insulin levels were significantly reduced (<em>P</em> <!-->=<!--> <!-->0.026) with no significant improvement in fasting blood glucose or insulin resistance index (HOMA-IR). Testosterone levels also fell significantly (<em>P</em> <!-->=<!--> <!-->0.003).</div></div><div><h3>Conclusion</h3><div>Mint, a traditional herbal remedy, has shown promising effects in women with PCOS. Our results suggest that it could improve several clinical and biological parameters, essentially signs of hyperandrogenism, cycle disorders, anthropometric measurements and metabolic indices. But a case-control study with a more representative sample is essential to validate these results.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101761"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine disruptors (EDs): Reducing exposure in hospitals and homes, a project supported by the Regional Health Agency (ARS)","authors":"Julie Beauvy,&nbsp;Laetitia Paradisi Prieur,&nbsp;Corine Yvinec,&nbsp;Irène Pandraud-Riguet,&nbsp;Leyre Martinez,&nbsp;Pauline Juttet,&nbsp;Anne Cécile Paepegaey,&nbsp;Erika Cornu,&nbsp;Vincent Mezzarobba,&nbsp;Jean-Philippe Le Berre","doi":"10.1016/j.ando.2025.101741","DOIUrl":"10.1016/j.ando.2025.101741","url":null,"abstract":"<div><h3>Introduction</h3><div>Endocrine disruptors (EDs), that mimic hormones, can cause various pathologies, with pregnant women and children being particularly vulnerable. Our institution received funding from the ARS to train staff, raise patient awareness, and reduce ED exposure in maternity care, coordinated by a multidisciplinary committee.</div></div><div><h3>Methods and results</h3><div>Training for hospital staff and liberal doctors, midwives, through FEES project (Pregnant Women Environment and Health) courses and conferences with experts (epidemiologists, toxicologists, endocrinologist specializing in infertility).</div><div>Patient awareness flyers distributed during endocrinology and gynecology consultations; interactive environmental health education workshops for pregnant women and patients in endocrinology; a teaching cabinet displaying everyday items to avoid or favor.</div><div>A satisfaction survey was completed by 255 patients (77% women, all ages). In all, 85% of patients find the initiative valuable, and 65% feel able to implement advice on textiles, indoor air quality, household products, food, food conservation, and cosmetics. Key barriers included cost, time constraints, and habits.</div><div>A QR code was created to educate pregnant women with gestational diabetes and conduct a multicentric epidemiological study on ED exposure (385 patients for now). Another QR code was elaborated, focused on endocrinological and gynecological conditions related to EDs (PCOS, endometriosis, thyroiditis, etc.) with 25 patients for now.</div><div>External audit of practices and diagnostic of products used in the facility, to identify pollution sources, and obtain the “Healthy Maternity” label from “Habitat-Santé-Environnement”. We analyzed 350 technical datasheets, safety data sheets, and drug characteristics (household products, cosmetics, medical devices, food, building materials). Improvements included for example: using eco-labeled detergents, removing spray air fresheners, and discontinuing Spasfon tablets (containing titanium dioxide).</div></div><div><h3>Discussion</h3><div>EDs have well-documented harmful effects on health. It is our duty to raise awareness among both caregivers and patients within healthcare institutions.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101741"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCOS gerbil model: Histopathological changes induced by chronic exposure to bisphenol A","authors":"Sara Belaidi,&nbsp;Abdelouafi Benmouloud,&nbsp;Nawel Aknoun-Sail,&nbsp;Salima Charallah","doi":"10.1016/j.ando.2025.101742","DOIUrl":"10.1016/j.ando.2025.101742","url":null,"abstract":"<div><h3>Introduction</h3><div>Recent studies indicate that exposure to environmental pollutants could play a significant role in both the development and pathophysiology of Polycystic Ovary Syndrome (PCOS).</div><div>This study investigates the impact of Bisphenol A (BPA) on reproductive health and its potential role in inducing Polycystic Ovary Syndrome (PCOS).</div></div><div><h3>Materials and methods</h3><div>Female gerbil (gerbilus tarabuli) aged 6–7 weeks were orally administered by Bisphenol A (50<!--> <!-->mg/kg/day) by gavage for 6 weeks. During the experiment, body weight and estrous cycle were monitored as the prolonged dioestrus phase indicates the ovulatory dysfunction. At the end of the experiment, the animals were sacrified and ovaries were dissected and fixed for histopathology study.</div></div><div><h3>Results and discussion</h3><div>Ovarian sections of the control group showed normal ovarian histoarchitecture: cortex with various stages of ovarian follicles and normal vascularity in the medulla. In BPA treated group, we noticed a decrease in the size of the cortex and disorganisation of the stroma. We observe numerous cystic follicles, with a decrease in number of antral follicles and corpora lutea and an increase of aretric follicles. We also observe a dilatation and congestion of the blood vessels.</div></div><div><h3>Conclusion</h3><div>Desert-dwelling rodents represent an important faunal heritage of the Algerian Sahara. They are known for their ability to develop various ecophysiological adaptive strategies that allow them to resist and survive in the harsh conditions of the arid environment. Their adaptive performance suggests the presence of endocrine and metabolic regulatory mechanisms, making them valuable experimental models for various fields of biological, medical, and pharmaceutical research.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101742"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}