Annales d'endocrinologie最新文献

{"title":"Altitude and paraganglioma","authors":"Julie Sanceau ,&nbsp;Rebecca Westbrook ,&nbsp;Judith Favier","doi":"10.1016/j.ando.2025.101772","DOIUrl":"10.1016/j.ando.2025.101772","url":null,"abstract":"<div><div>The relationship between altitude and the development of paragangliomas (PGLs), rare tumors within the sympathetic nervous system has been suggested since the early 1970's. Here, we discuss how altitude, marked by lower barometric pressure and hypoxia (reduced oxygen partial pressure), may influence cancer rates. Chronic hypoxia triggers physiological changes, such as carotid body (CB) hyperplasia and a higher incidence of head and neck paragangliomas (HN-PGL) which has been reported in high-altitude populations, with a predominance of females among affected individuals. The involvement of hypoxia signalling in PGL tumorigenesis is further reinforced by the demonstration that genetic mutations, (particularly in <em>VHL</em>, <em>SDHx</em> and <em>EPAS1</em> genes) cause a pseudo-hypoxic response. Furthermore, somatic mutations in <em>EPAS1</em> are also linked to an increased risk of PGL in individuals with chronic hypoxemic conditions such as cyanotic congenital heart disease or haemoglobin diseases. Altogether, this review emphasizes the unique sensitivity of paragangliomas to hypoxic signalling, and shows that whether due to low environmental oxygen at high altitudes, diseases, or genetic mutations, hypoxia plays a pivotal role in PGL formation.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101772"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iodine and thyroid hormones – modelling moderate iodine deficiency with sodium perchlorate in mice","authors":"Anni Herranen ,&nbsp;Patricia Rannaud-Bartaire ,&nbsp;Raphaëlle Escoude ,&nbsp;Annabelle Manoury ,&nbsp;Céline Bouvier-Capely ,&nbsp;Jean-Baptiste Fini","doi":"10.1016/j.ando.2025.101748","DOIUrl":"10.1016/j.ando.2025.101748","url":null,"abstract":"<div><h3>Introduction</h3><div>Iodine is an essential trace element for thyroid hormone (TH) production. In adults, THs play important roles in almost all organ systems including heart, lungs, skeletal muscles and metabolism. Iodine is taken in by ingestion and its intake is decreasing in many countries leading to mild iodine deficiency especially in Europe. Several mouse models exist for a severe iodine deficiency that leads to a decrease in TH levels but not many studies have addressed mild iodine deficiency.</div></div><div><h3>Materials and methods</h3><div>We studied the possibility to create a mouse model for moderate iodine deficiency with exposure to sodium perchlorate, which blocks iodine transport to thyrocytes. Two doses of perchlorate, 1 and 5<!--> <!-->μg/mL, were administered via drinking water to male and female 2-month-old C57BL/6<!--> <!-->J mice for 5 weeks and circulating TH and iodine levels were measured. Body weight and fluid consumption were analysed throughout the exposure.</div></div><div><h3>Results and discussion</h3><div>Thyroid morphology and follicle size were analysed in the end of the exposure. The high dose animals had increased liquid consumption, their thyroid morphology was severely damaged, they displayed a decrease in circulating thyroxine levels and their circulating iodine levels were decreased in both sexes. The low dose animals displayed decreased thyroid follicle size but without a decrease in circulating T4 levels except for females after 5 weeks of exposure. In the low dose animals, the circulating iodine levels did not decrease but a tendency to diminished iodine levels was observed in females. We could thus show differential responses to perchlorate exposure between sexes and propose the low dose, 1<!--> <!-->μg/mL, of perchlorate as a model for moderate iodine deficiency.</div></div><div><h3>Conclusion</h3><div>Moderate iodine deficiency, especially during pregnancy when the needs double, could make individuals more vulnerable to environmental pollution targeting TH signalling.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101748"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrative study on behavioral and neurodevelopmental effects of exposure to human breastmilk mixture of endocrine disrupting compounds","authors":"Manon Letard,&nbsp;Camille Maladin,&nbsp;Antoine Proost-Matencio,&nbsp;Elodie Desroziers,&nbsp;Sakina Mhaouty-Kodja","doi":"10.1016/j.ando.2025.101751","DOIUrl":"10.1016/j.ando.2025.101751","url":null,"abstract":"<div><h3>Introduction</h3><div>Human populations are exposed to a variety of chemical substances through environmental pollution, ensuing in contamination by heterogeneous mixtures of substances. However, human health risk assessment is still carried out on a substance-by-substance basis.</div></div><div><h3>Materials and methods</h3><div>In this context, the team has contributed to the development of a new methodological approach for assessing the chemical risk of heterogeneous contaminants mixtures. This methodology was applied to the French ContaLait survey, which measured several contaminants in breast milk. This initial theoretical assessment of combined risks suggests a high risk for neurodevelopmental processes including motor and cognitive functions. Thus, our study aims to generate experimental data to establish and improve this methodology by characterizing the effects of this human breast milk contaminants mixture on motor and cognitive processes. Eight-week-old C57BL6/J females were orally exposed to a mixture of breast milk contaminants containing the 5 “drivers” identified by the theoretical approach (PCB153, DDE, 2,3,7,8-TCDD, dieldrin, arsenic) at the estimated environmental dose and at doses 10 and 25 times more concentrated. Exposure was carried out two weeks before mating, then during gestation and lactation.</div></div><div><h3>Results and discussion</h3><div>Our initial results show that, whatever the dose, the mixture has no effect on maternal weight, litter size or pup survival. A dose-dependant treatment effect was observed on body growth, developmental markers such as fur growth, eye opening and age at puberty in male and female offspring.</div></div><div><h3>Conclusion and limitations</h3><div>Finally, analyses are underway to determine the effects of exposure to human breast milk mix at different doses on locomotion, anxiety, as well as temporal and spatial memory in adult male and female offspring.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101751"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular and molecular effects of exposure to BPA alternatives in hippocampal neurons derived from human induced pluripotent cells","authors":"Lydie Naulé,&nbsp;Maria Rey,&nbsp;Sakina Mhaouty-Kodja","doi":"10.1016/j.ando.2025.101753","DOIUrl":"10.1016/j.ando.2025.101753","url":null,"abstract":"<div><h3>Introduction</h3><div>Bisphenol A (BPA) is used in epoxy resins and polycarbonate containers for storage of foods and beverages. BPA has been classified as a substance of very high concern by the European Chemical Agency. Adverse effects were identified on learning and memory, via an estrogenic mode of action. Due to BPA restrictions, substitutes have been developed, yet data on their toxicity are limited.</div></div><div><h3>Materials and methods</h3><div>In this project, we are using hippocampal neurons derived from human induced pluripotent stem cells (hiPSCs) to assess the effects of a chronic treatment of BPA and substitutes at cellular and molecular levels.</div></div><div><h3>Results and discussion</h3><div>Inhibition of WNT, TGFβ and BMP signalling pathways, followed by WNT activation, induces differentiation of hiPSCs into hippocampal neural progenitors (hNPCs) within 28 days. BDNF treatment promotes neuronal maturation. RT-qPCR analyses showed that hiPSCs expressing octamer-binding transcription factor 4- (OCT-4) differentiated with high efficiency into hNPCs, expressing NESTIN and hippocampal progenitor markers prospero homeobox 1 (PROX1) and zinc finger and BTB domain containing 20 (ZBT20). Neuronal marker microtubule associated protein 2 (MAP2), and hippocampal markers ELAV like RNA binding protein 2 (ELAVL2) and glutamate ionotropic receptor kainate 4 (GRIK4) were expressed in mature neurons at day 43. hNPCs were treated chronically (14 days) with increasing concentrations (0.001, 0.01, 0.1, 1, 10, and 100<!--> <!-->μM) of BPA and substitutes BPAP, BPE and BPZ. All bisphenols showed a concentration-dependent decrease in cell viability, with a significant decrease at 100<!--> <!-->μM for BPA, BPAP and BPZ and from 10<!--> <!-->μm for BPE. Then, hNPCs were treated with non-toxic doses for 14 days. RNA has been extracted, and gene expression analysis of potential key gene targets is underway. Immunocytochemistry for β-III tubulin has been performed to analyze neuronal morphology. Protein levels of presynaptic and postsynaptic markers will also be quantified to measure the impact of treatments on synaptic plasticity.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101753"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe cutaneous adverse reactions to allopurinol in the elderly: A case series","authors":"Mohamed Amine Fouad ,&nbsp;Nesrine Ben Salah ,&nbsp;Khadija Mansour ,&nbsp;Mouna Korbi ,&nbsp;Manel Ben Belgacem ,&nbsp;Zohra Chadli ,&nbsp;Hichem Bel Hadj Ali ,&nbsp;Karim Aouam ,&nbsp;Jameleddine Zili","doi":"10.1016/j.ando.2025.101746","DOIUrl":"10.1016/j.ando.2025.101746","url":null,"abstract":"<div><h3>Introduction</h3><div>Severe cutaneous adverse drug reactions (SCARs) are serious and potentially life-threatening skin reactions associated with medications used for preventive or therapeutic purposes. This study aims to describe the epidemiological, clinical, evolutionary, and prognostic characteristics of severe allopurinol-induced eruption in the geriatric population.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective study including all patients aged 65 years or older between 2005 and 2025 who presented with SCARs and confirmed allopurinol causality based on pharmacovigilance investigations. Among 42 patients with SCARs, 20 cases induced by allopurinol were included.</div></div><div><h3>Results and discussion</h3><div>The mean age was 73.3 years, with a male-to-female ratio of 0.11. The primary indications for allopurinol were gout (55%) and hyperuricemia (15%). The drug-induced skin reaction cases included DRESS syndrome (80%), toxic epidermal necrolysis (10%), and Stevens-Johnson syndrome (10%). The average time to onset was 20 days. The predominant clinical presentation was generalized maculopapular exanthema. Fever and mucosal involvement were observed in 60 and 40% of cases, respectively. Hyper eosinophilia was noted in 15 patients. Management involved discontinuation of allopurinol and initiation of symptomatic treatment. The outcome was mostly favorable, although two deaths were reported.</div></div><div><h3>Conclusion</h3><div>Allopurinol is one of the most frequently implicated drugs in SCARs, with a higher prevalence in the elderly due to its widespread use in this population. DRESS syndrome is the most common reaction. Although the prognosis is relatively good, it is crucial to avoid allopurinol use in asymptomatic hyperuricemia and to enhance clinical vigilance to prevent these potentially fatal complications. This study highlights the importance of careful drug monitoring and the need for alternative therapeutic strategies in the geriatric population to minimize the risk of severe adverse reactions.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101746"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous sarcoidosis beyond the skin: Exploring endocrine comorbidities","authors":"Mohamed Amine Fouad ,&nbsp;Nesrine Ben Salah ,&nbsp;Mouna Korbi ,&nbsp;Yousra Soua ,&nbsp;Asma Mabrouk ,&nbsp;Hichem Bel Hadj Ali ,&nbsp;Jameleddine Zili","doi":"10.1016/j.ando.2025.101747","DOIUrl":"10.1016/j.ando.2025.101747","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcoidosis is a chronic systemic inflammatory disease characterized by tissue infiltration of non-caseating granulomas. This study aims to identify endocrine disorders associated with sarcoidosis and determine their frequency in cutaneous sarcoidosis.</div></div><div><h3>Materials and methods</h3><div>A retrospective study was conducted between 2017 and 2025, including all patients followed for cutaneous sarcoidosis. The study included 11 patients, all female, with a mean age of 65.4 years (range: 57–73 years).</div></div><div><h3>Results and discussion</h3><div>Five cases presented with associated endocrinopathies: diabetes mellitus in 3 cases (2 with type 2 diabetes and 1 with type 1 diabetes), hypothyroidism in 1 case, and dyslipidemia in 1 case. The localization was cutaneous in all cases, pulmonary in 4 cases, hepatic in 1 case, and ophthalmological in 1 case. Treatment involved oral corticosteroids in 10 patients, while 1 patient received hydroxychloroquine due to isolated cutaneous involvement. The association between cutaneous sarcoidosis and endocrinopathies is rarely reported in the literature. Potential mechanisms include a direct effect on endocrine glands, shared pathophysiological pathways, or the effects of treatment, particularly corticosteroids.</div></div><div><h3>Conclusion</h3><div>This study highlights the importance of screening for endocrine comorbidities in patients with cutaneous sarcoidosis to optimize management. In conclusion, although endocrinopathies are uncommon, they can accompany cutaneous sarcoidosis. Their identification requires clinical vigilance and a multidisciplinary approach to improve overall patient care.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101747"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paramedical approach to corticotherapy: Knowledge and practices of nurses regarding risks and monitoring","authors":"Imen Somrani,&nbsp;Imen Mariem Abbassi,&nbsp;Mariem Essouri,&nbsp;Zeineb Teyeb,&nbsp;Naziha Khammassi","doi":"10.1016/j.ando.2025.101760","DOIUrl":"10.1016/j.ando.2025.101760","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Corticosteroids are widely prescribed in outpatient settings or during hospitalizations in various healthcare facilities. They are indicated for numerous acute or chronic conditions, particularly autoimmune and inflammatory diseases, in Internal Medicine and Neurology. Adequate knowledge of the paramedical team regarding corticosteroid therapy is essential to improve the management of patients undergoing these treatments.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This was a descriptive cross-sectional study conducted at a psychiatric hospital over a three- week period in February 2025. All nurses working in the medical departments of the hospital (Internal Medicine and Neurology) were included, totaling 34 nurses. Intern nurses and those who did not fully complete the questionnaire were excluded.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Thirty nurses responded to the questionnaire, with a mean age of 41.7 years [25–62 years]. Twenty-one nurses (75%) worked in Neurology, and 9 nurses (25%) worked in Internal Medicine. Twenty-four nurses (80%) had over 5 years of professional experience, with 54% (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;13) having more than 10 years of experience.&lt;/div&gt;&lt;div&gt;More than half of the nurses (53%) stated that corticosteroids were primarily used for chronic inflammatory diseases, without specifying the effects of the treatment. Four nurses (13%) mentioned that corticosteroids were also natural hormones.&lt;/div&gt;&lt;div&gt;All nurses indicated that pre-therapeutic examinations were necessary, including blood pressure measurement (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;29), capillary blood glucose (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;27), weight measurement (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;24), and urine strips (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;16). The pre-therapeutic blood tests included a blood ionogram (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;19), calcium level (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;12), and lipid profile (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;8).&lt;/div&gt;&lt;div&gt;Corticosteroid administration was mostly done in the morning, as reported by 93% of the nurses (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;28), while 7% opted for evening administration (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;2). The most frequently mentioned routes of administration were intravenous (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;28, 93%), oral (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;27, 90%), inhaled (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;19, 63%), and intramuscular (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;16, 53%).&lt;/div&gt;&lt;div&gt;A high dose of corticosteroid therapy was defined by the majority (64%) as being greater than 1&lt;!--&gt; &lt;!--&gt;mg/kg/day (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;19). The initiation of this dose required hospitalization, according to 90% of nurses (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;27). Corticosteroid therapy was considered long-term if it exceeded 3 weeks for 39% of nurses (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;11), and more than 3 months for 43% (&lt;em&gt;n&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;13).&lt;/div&gt;&lt;div&gt;The most frequently mentioned short-term side effects were hyperglycemia (83%, &lt;em&gt;n&lt;/e","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101760"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a therapeutic dose of folic acid after bariatric surgery and its impact on mental well-being","authors":"Natia Romashvili,&nbsp;Nino Chochnidze","doi":"10.1016/j.ando.2025.101757","DOIUrl":"10.1016/j.ando.2025.101757","url":null,"abstract":"<div><h3>Objective</h3><div>This study will examine the role of folic acid in bariatric patients and its impact on psychological health. A mixed methods approach will be used to gain a deeper understanding of how this B9 regulation affects individuals’ attitudes, mental states, and behaviors. The results of this study aim to raise awareness of the value of B9 in long-term weight-related challenges and provide valuable information on health.</div></div><div><h3>Methods</h3><div>The study will utilize a mixed-methods approach, combining quantitative surveys with qualitative interviews to assess quality. The study was conducted in the bariatric surgery department of Aversi Clinic in 2021–2024. Sixty patients were divided into two groups. In the first group, folate levels were determined before surgery and during shortages treatment was started at 800 mcg per day, In the second group, B9 was not prescribed before surgery, so they did not take in a therapeutic dose for the first month.</div></div><div><h3>Results</h3><div>As a result of observation and data analysis, it was revealed that, In the first group of patients, 76%, who received therapeutic doses of B9, the postoperative period was calm, anxiety was not detected at a high rate; also, depression was detected in only four patients, and adherence to the post-bariatric diet and recommendations was high. In the group that did not receive folic acid, 63%, relatively high anxiety and depression were observed. As for the result, it was more or less satisfactory.</div></div><div><h3>Conclusion</h3><div>This study aspires to identify sustainable strategies for maintaining how B9 can play an important role in enhancing both physical and mental health, ultimately contributing to successful and enduring weight loss during surgery. Therefore, based on the data obtained, it can be assumed that the research design, which aimed to determine B9's role, was evident even in a small study; which also increased the achievement of treatment results and patient compliance.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101757"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic study of adrenal stress genes in rats exposed to 5G electromagnetic fields","authors":"Lise Ronger ,&nbsp;Mathilde Ramelet ,&nbsp;Amandine Pelletier ,&nbsp;Rachel Desailloud ,&nbsp;Abdallah Al-Salameh ,&nbsp;Chandreshwar Seewooruttun","doi":"10.1016/j.ando.2025.101758","DOIUrl":"10.1016/j.ando.2025.101758","url":null,"abstract":"<div><h3>Introduction</h3><div>The biological effects of 5G electromagnetic fields on living organisms are poorly understood. Studies suggested that exposure to radio frequencies, and notably 2G fields (900<!--> <!-->MHz), may alter the structure and function of the adrenal glands, impacting hormonal response to stress. The effect of 5G fields (3.5<!--> <!-->GHz) on these mechanisms, however, is not known.</div></div><div><h3>Objective</h3><div>To assess the impact of exposure to 2G and 5G electromagnetic fields on the expression of genes involved in the adrenal stress response in rats at different developmental stages.</div></div><div><h3>Material and methods</h3><div>Male Wistar rats were divided into 2 age groups: juveniles (3 weeks) and young adults (8 weeks). They were exposed to 900<!--> <!-->MHz (2G) and 3.5<!--> <!-->GHz (5G) electromagnetic fields at an intensity of 1.5<!--> <!-->V/m in 2 daily 1-hour sessions, for 2 weeks. Expression of adrenal stress genes (CH25H and StAR) and corticosteroidogenic enzymatic cofactors (CYP-11a1, CYP-21a1 and HSD-3b1) was assessed on RT-qPCR.</div></div><div><h3>Results</h3><div>No significant changes in transcriptomic expression were observed, whatever the developmental stage or exposure intensity. Grouping the animals by exposure condition revealed no significant effect of electromagnetic fields on the adrenal markers studied (<span><span>Figure 1</span></span>).</div></div><div><h3>Discussion and conclusion</h3><div>Contrary to some studies suggesting an effect of radio frequencies on adrenal function, in the present study 2-week exposure to 5G or 2G fields did not alter the expression of stress genes. It would be useful to explore longer exposure and higher intensity to assess possible long-term effects and reproduce real-life conditions of exposure to electromagnetic fields.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101758"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Éditorial","authors":"Albert Beckers (Professeur, Président du Conseil Scientifique des Journées KLOTZ-2025, Vice-Président de l’Académie Royale de Médecine de Belgique)","doi":"10.1016/j.ando.2025.101736","DOIUrl":"10.1016/j.ando.2025.101736","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101736"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}