Annales d'endocrinologie最新文献

{"title":"The thyroid hormone system and its disruption","authors":"Anni Herranen , Patricia Rannaud-Bartaire , Jean-Baptiste Fini","doi":"10.1016/j.ando.2025.101773","DOIUrl":"10.1016/j.ando.2025.101773","url":null,"abstract":"","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101773"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between hyperprolactinemia, metabolic disorders and cardiovascular risk in patients with prolactinoma","authors":"Zineb Eddebbarh ,&nbsp;Zineb Ayouche ,&nbsp;Zineb El Azime ,&nbsp;Mohamed Amine Essafi ,&nbsp;Hayat Aynaou ,&nbsp;Houda Salhi","doi":"10.1016/j.ando.2025.101745","DOIUrl":"10.1016/j.ando.2025.101745","url":null,"abstract":"<div><h3>Introduction</h3><div>Prolactinomas are the most common type of pituitary adenoma, however suppression of negative dopamine feedback, as well as CNS lipogenesis and dopaminergic tone, are mechanisms responsible for weight gain and metabolic abnormalities.</div></div><div><h3>Objective</h3><div>To determine the prevalence of metabolic disorders and assess cardiovascular risk in patients with hyperprolactinemia secondary to pituitary adenoma.</div></div><div><h3>Materials and methods</h3><div>Retrospective study spread over 3 years. The diagnosis of metabolic syndrome retained according to IDF 2023 criteria. The level of cardiovascular risk estimated by the Framingham score and score 2 for diabetics. Statistical analysis was performed using SPSS 26 software. Our patients were classified into group A: patients with positive metabolic syndrome and group B with negative metabolic syndrome.</div></div><div><h3>Results</h3><div>In all, 80 patients were included. Mean age was 38.17<!--> <!-->±<!--> <!-->14.61 years and sex ratio was 2.06. Mean BMI was 25.34<!--> <!-->±<!--> <!-->9.94<!--> <!-->kg/m². Mean waist circumference was 75.98<!--> <!-->±<!--> <!-->10.7<!--> <!-->kg/cm². Prevalences of obesity, hypertension, diabetes, hypertriglyceridemia and hypoHDLemia were 34, 18, 11, 61, 79% respectively.</div><div>In group A: mean prolactin level was 765.6<!--> <!-->ng/mL, mean cardiovascular risk was 15.8<!--> <!-->±<!--> <!-->4.25%. Group B: mean prolactin level 325.8<!--> <!-->ng/mL, mean cardiovascular risk 7.23<!--> <!-->±<!--> <!-->3.8%.</div><div>Multivariate analysis revealed a significant association between mean prolactin (<em>P</em> &lt;<!--> <!-->0.001), metabolic disorders (<em>P</em> <!-->=<!--> <!-->0.029) and cardiovascular risk (<em>P</em> <!-->=<!--> <!-->0.019).</div></div><div><h3>Conclusion</h3><div>The metabolic syndrome and its parameters are responsible for an increase in cardiovascular risk, hence the interest of treatment with dopaminergic agonists to improve its parameters, as illustrated in our study.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101745"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health, anxiety, depression and risk of dysthyroidism","authors":"Fabrice Bonnet ,&nbsp;Juanjuan Zhang ,&nbsp;Yuerong He ,&nbsp;Ruiqi An ,&nbsp;Jie Bai ,&nbsp;Jianping Gong ,&nbsp;Yafei Zhou ,&nbsp;Yang Xia","doi":"10.1016/j.ando.2025.101744","DOIUrl":"10.1016/j.ando.2025.101744","url":null,"abstract":"<div><h3>Background</h3><div>Psychological stress has been implicated in several autoimmune pathologies, but the relationship between mental health and dysthyroidism has not been clearly elucidated. The aim of the present study was to prospectively assess the relationship between mental health and incident risk of dysthyroidism.</div></div><div><h3>Population</h3><div>In all, 418,622 UK Biobank participants, without dysthyroidism at baseline, were included. Mental health was assessed at inclusion on the Patient Health Questionnaire-4 (PHQ-4). Subsequent diagnoses of hyper- or hypo-thyroidism were extracted from medical files. Survival curves were used to compare incidence of dysthyroidism according to PHQ-4 score on a multivariate Cox model.</div></div><div><h3>Results</h3><div>Over a median 12.3 years’ follow-up, there were 2242 and 9419 new cases of hyper- and hypo-thyroidism, respectively. There was a gradual association between baseline mental health score and incident risk of dysthyroidism: HR for 1 standard deviation: 1.13 (95% CI: 1.08–1.18); <em>P</em> &lt;0.001 for hyperthyroidism, and 1.11 (95% CI: 1.09–1.13); <em>P</em> &lt;0.001 for hypothyroidism. Subjects with poorer mental health on the PHQ-4 had greater risk of developing hyperthyroidism (adjusted HR: 1.70; 95% CI: 1.09–2.65) or hypothyroidism (adjusted HR: 1.70; 95% CI: 1.36–2.12) than those with better mental health. Anxiety and depression, considered separately, were both significantly associated with risk of dysthyroidism. The results were the same using clinical diagnoses instead of PHQ-4 scores.</div></div><div><h3>Conclusion</h3><div>Mental health, anxiety and depression were significantly associated with onset of hyper- or hypo-thyroidism in the general population. These findings support monitoring thyroid function in subjects experiencing psychological suffering.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101744"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a mixture of organic pollutants on the thyroid axis","authors":"Manon Bonnelle ,&nbsp;Sébastien Le Mével ,&nbsp;Clara Han ,&nbsp;Stéphane Reynaud ,&nbsp;Jean-Baptiste Fini","doi":"10.1016/j.ando.2025.101743","DOIUrl":"10.1016/j.ando.2025.101743","url":null,"abstract":"<div><h3>Introduction</h3><div>Endocrine disruptors (EDs) are widely recognized for their adverse effects on human and environmental health. Studies suggest that their ubiquitous presence impacts amphibian metabolism, contributing to their decline over several decades.</div></div><div><h3>Materials and methods</h3><div>A mixture of six obesogenic EDs (TBT, TCS, DDE, PBDE, BaP, and DEHP) was studied at concentrations corresponding to environmental quality standards (EQS) over short- and long-term exposure periods in Xenopus tropicalis at three developmental stages (NF 47, 62, and 65). Particular attention was given to the thyroid system, which plays a key role in metabolic regulation.</div></div><div><h3>Results and discussion</h3><div>The results show that short-term exposure induces increased proliferation and reduced cell mortality in the brains of exposed tadpoles. Additionally, a significant increase in mobility was observed in darkness during the active phase. At the molecular level, exposure to the mixture led to alterations in the expression of specific genes.</div><div>In the long term, histological analysis of the thyroid glands revealed structural changes, characterized by a reduction in colloid content, clusters of thyrocytes, and follicular disorganization.</div></div><div><h3>Conclusion</h3><div>These findings indicate that this obesogenic mixture is not inert at the tested EQS concentrations in exposed frogs, highlighting the importance of studying chemical mixtures rather than individual compounds.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101743"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representation of endocrine organs in TCDD physiologically-based toxicokinetics (PBTK) models","authors":"Argyro Nikolaou ,&nbsp;Caroline Flora Samer","doi":"10.1016/j.ando.2025.101754","DOIUrl":"10.1016/j.ando.2025.101754","url":null,"abstract":"<div><h3>Introduction</h3><div>Endocrine disruptors (EDCs) are common environmental contaminants with concerning effects on multiple biological systems, notably the endocrine system <span><span>[1]</span></span>. Dioxins, a well-known class of EDCs, have been associated with thyroid and reproductive disorders in humans <span><span>[2]</span></span>, <span><span>[3]</span></span>. Among them, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is most toxic, characterized by its persistence and bioaccumulation due to its lipophilic nature. Understanding TCDD toxicokinetics is crucial for assessing its health risks. Given its complex metabolism <span><span>[4]</span></span>, physiologically-based toxicokinetics (PBTK)–an extension of physiology-based pharmacokinetic (PBPK) models–provide an in silico approach to estimate xenobiotics kinetics using in vitro and in vivo data. We reviewed the existing PBTK models for TCDD, with a particular focus on the inclusion of endocrine organs.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in Pubmed, EMBASE and Google Scholar for PBTK models published up to October 2024. A total of 408 articles were identified, of which 31 met the inclusion criteria for review.</div></div><div><h3>Results</h3><div>The majority of PBTK models did not explicitly account for endocrine tissues. Instead, they broadly categorized organs as either slowly or richly perfused. Only a few models incorporated endocrine related structures, with the placenta included in three models and the mammary gland in two.</div></div><div><h3>Conclusions</h3><div>No PBTK models have independently assessed endocrine organs such as the thyroid, testis, or ovaries in the context of TCDD toxicokinetics. Given the mounting evidence of EDC-related health effect, integrating endocrine organs into PBTK models could enhance our understanding of EDC toxicokinetics and their adverse effects.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101754"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of seasonal variations, castration and testosterone treatment on weight and histomorphometry of anterior prostatic lobes in the Saharan gerbil, Gerbillus tarabuli","authors":"Arezki Kheddache ,&nbsp;Yamina Zatra ,&nbsp;Kamilia Henna ,&nbsp;Naouel Aknoun ,&nbsp;Salima Charallah ,&nbsp;Zaina Amirat ,&nbsp;Farida Khammar","doi":"10.1016/j.ando.2025.101749","DOIUrl":"10.1016/j.ando.2025.101749","url":null,"abstract":"<div><h3>Introduction</h3><div>This study analyses the effects of seasonal variations, castration and testosterone treatment on the anterior prostatic lobes of the Saharan gerbil (<em>Gerbillus tarabuli</em>).</div></div><div><h3>Materials and methods</h3><div>This rodent was captured in the Béni-Abbés region (30°7’N, 2°10’W; Algeria) during the resting period in autumn and the testicular activity period in spring. Castration and replacement treatment were also carried out in the spring.</div></div><div><h3>Results and discussion</h3><div>Castration and the decline in testosterone levels during the period of sexual rest induce atrophy of the anterior prostatic lobes. Histological and morphometric alterations are observed, characterised by increased fibromuscular stromal growth and epithelial regression. The heights of the epithelial cells and supranuclear zone are significantly reduced.</div><div>The weight of the anterior prostatic lobes is restored in the spring and after testosterone treatment of castrated animals. Testosterone treatment leads to the reappearance of the histological images observed in gonadally active animals, including a poorly developed fibromuscular wall and the mucosa developing very long epithelial folds which sink into the centre of a very wide lumen filled with secretions.</div></div><div><h3>Conclusion</h3><div>Further studies are required to provide a more comprehensive understanding of the functions and regulation of the prostatic lobes in the Saharan gerbil <em>Gerbillus tarabuli</em>.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101749"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of scrotal heat stress on testicular histology and function in a Saharan rodent, Meriones libycus","authors":"Arezki Kheddache ,&nbsp;Salima Charallah ,&nbsp;Elara N. Moudilou ,&nbsp;Claire Brun ,&nbsp;Jeremy Terrien","doi":"10.1016/j.ando.2025.101750","DOIUrl":"10.1016/j.ando.2025.101750","url":null,"abstract":"<div><h3>Introduction</h3><div>In this study, we investigated the effects of scrotal heat stress on the Libyan jird (<em>Meriones libycus</em>), a nocturnal Saharan rodent.</div></div><div><h3>Materials and methods</h3><div>For this, animals were captured during the testicular activity period in spring and parameters including body weight, sperm quality, histology of the testis and endocrine factors were analyzed under different temperature conditions. A total of 14 mature adult <em>Meriones libycus</em> were allocated into two groups (<em>n</em> <!-->=<!--> <!-->7/each). The heat-stress group was submerged in a water bath at 43<!--> <!-->°C for 30<!--> <!-->min during 2 consecutive days, while the control group was treated at 25<!--> <!-->°C. Animals were all sacrificed. The testes with reproductive organs were removed, weighed and fixed for histological examination. Plasma was preserved for hormone assays and sperm parameters were determined.</div></div><div><h3>Results and discussion</h3><div>Body weight, proximal epididymis, seminal vesicles and ventral prostate weights showed no significant difference between the two batches of animals. On the other hand, distal epididymis and testicular weights decreased significantly when animals were subjected to scrotal heat stress. Testicular atrophy could be observed in the stress group and characterized by remarkable histological alterations: shrunken seminiferous tubules, germinal epithelium reduced to a bed of spermatogonia with cessation of spermatogenesis and absence of spermatozoa inside an empty lumen. These histological alterations resulted in an alteration in sperm parameters: oligospermia with a considerable drop in sperm motility and vitality, and changes in the sperm count. Plasma testosterone levels dropped significantly under the stress situation.</div></div><div><h3>Conclusion</h3><div>These results confirm that optimal function of testicles is at a temperature a few degrees below body temperature. When the scrotum is exposed to higher temperatures as a result of global warming, Leydig cell function and spermatogenesis are impaired, and fertility is compromised.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101750"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual behavior in male mice is impaired by an obesogenic-diabetogenic diet and worsened by exposure to a relevant environmental mixture of phthalates","authors":"Lina Mahiddine,&nbsp;Caroline Parmentier,&nbsp;Sakina Mhaouty-Kodja,&nbsp;Hélène Hardin-Pouzet","doi":"10.1016/j.ando.2025.101752","DOIUrl":"10.1016/j.ando.2025.101752","url":null,"abstract":"<div><h3>Introduction</h3><div>The decrease in male fertility observed since the beginning of the 20th century in Western countries could be linked to changes in diets and exposure to molecules from industry, such as endocrine disruptors and among them, phthalates.</div></div><div><h3>Materials and methods</h3><div>Modelling Western lifestyle, the combined effects of a high fat/high fructose diet (HFHF) and exposure to an environmental mixture of phthalates (mix) were evaluated on male murine sexual behavior. Four groups of adult male C57Bl/6<!--> <!-->J mice were exposed during 17 weeks to a control diet (CD), a control diet coupled with the mix (CDmix), an HFHF diet, and an HFHF diet coupled with the mix (HFHFmix).</div></div><div><h3>Results and discussion</h3><div>Both HFHF and HFHFmix diets induced metabolic alterations, reminiscent of a type 2 diabetes. The HFHFmix diet altered the efficiency of sexual behavior, with a dramatic decrease in the number of animals reaching ejaculation and a subsequent increase in mating latency. This impairment was far over than the effect of the mix treatment alone. HFHFmix effect was associated with a decrease in testicular, seminal glands and Tyson glands weights and a loss in discrimination toward female counterparts in an olfactory preference test. No effects were recorded on locomotion activity. The effect of the HFHFmix on the cellular and molecular markers of the preoptic area of the hypothalamus (mPOA), the main integrating center in the control of male sexual behavior, demonstrated an alteration in the neural network.</div></div><div><h3>Conclusion</h3><div>Thus, the synergistic effect of an HFHF diet and exposure to phthalates, at doses relevant for human exposure, on male sexual behavior, revealed a specific vulnerability of the central nervous system. This requires special attention in term of public health recommendations.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101752"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-müllerian hormone: A new diagnostic marker for polycystic ovary syndrome?","authors":"Myriam Baltagi,&nbsp;Marwa Chiboub,&nbsp;Mariem Adel,&nbsp;Marwa Abdennour,&nbsp;Radhouen Gharbi,&nbsp;Manel Jemel,&nbsp;Ines Kammoun","doi":"10.1016/j.ando.2025.101739","DOIUrl":"10.1016/j.ando.2025.101739","url":null,"abstract":"<div><h3>Introduction</h3><div>Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5–15% of women of reproductive age. Diagnosis based on the Rotterdam criteria includes ovarian ultrasound, which is operator-dependent and subject to several limitations. Anti-Müllerian hormone (AMH), produced by granulosa cells of antral follicles, is emerging as an alternative biomarker. This study aims to determine an optimal AMH diagnostic threshold for Tunisian women.</div></div><div><h3>Materials and methods</h3><div>This multicenter, cross-sectional case-control study included 31 PCOS patients diagnosed according to the Rotterdam criteria and 31 age- and BMI-matched controls. Serum AMH levels were measured using an electrochemiluminescence assay. Pelvic ultrasound was performed transabdominally and, when feasible, transvaginally or transrectally. Correlations between AMH, age, testosterone levels, and antral follicle count were assessed using linear regression analysis.</div></div><div><h3>Results and discussion</h3><div>The mean AMH level was 3.6 times higher in PCOS patients (7.69<!--> <!-->ng/mL) than in controls (2.12<!--> <!-->ng/mL; <em>P</em> &lt;10⁻³). A significant positive correlation was observed between AMH and antral follicle count (B<!--> <!-->=<!--> <!-->0.25; <em>P</em> &lt;10⁻³) as well as with testosterone levels (B<!--> <!-->=<!--> <!-->0.07; <em>P</em> &lt;10⁻³). A negative correlation with age (B<!--> <!-->=<!--> <!-->−0.15; <em>P</em> &lt;10⁻³) was also demonstrated. ROC curve analysis identified an optimal diagnostic threshold of 3.41<!--> <!-->ng/mL, with a sensitivity of 97% and a specificity of 90%.</div></div><div><h3>Conclusion and limitations</h3><div>AMH is a reliable biomarker for PCOS in hyperandrogenic Tunisian women, potentially replacing ovarian ultrasound when it is unavailable, inconclusive, or lacks an experienced operator. Study limitations include the absence of phenotype D in our cohort and the need for validation in larger populations.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 3","pages":"Article 101739"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kisspeptin system–physiology and clinical perspectives","authors":"Nikolay Stoynev ,&nbsp;Philip Kumanov","doi":"10.1016/j.ando.2025.101793","DOIUrl":"10.1016/j.ando.2025.101793","url":null,"abstract":"<div><h3>Purpose</h3><div>To summarize the state of knowledge on kisspeptin, a factor that alters the migration properties of some types of cancer cell and also plays an important role in the control of the reproductive axis.</div></div><div><h3>Methods</h3><div>PubMed search, identifying the most recent relevant information.</div></div><div><h3>Results</h3><div>This review describes the physiological aspects about the regulation of kisspeptin release and its place in the regulation of reproductive axis. Kisspeptin's role in puberty and its interaction with male and female reproductive axis are discussed along with potential clinical perspectives. Further analysis was made of the interaction of kisspeptin with centrally acting metabolic factors and on the presence of the kisspeptin system in some organs outside the reproductive tract: pancreas, liver, and adipose tissue. The kisspeptin system is a factor that alters the metastatic potential in various cancer types–malignant melanoma, breast cancer, colorectal cancer, gastric carcinoma, thyroid carcinoma, hepatocellular carcinoma, etc. Additionally, kisspeptin has also been reported to induce dormancy in already disseminated tumor cells, thus suppressing metastatic colonization in multiple organs.</div></div><div><h3>Conclusion</h3><div>The kisspeptin system could in future provide additional diagnostic tests and even therapeutic targets and procedures for the management of some reproductive disorders. As a factor involved in suppression of metastasis, it may in future have significant value for prognosis and/or follow-up in various cancer types.</div></div>","PeriodicalId":7917,"journal":{"name":"Annales d'endocrinologie","volume":"86 4","pages":"Article 101793"},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}