Effects of seasonal variations, castration and testosterone treatment on weight and histomorphometry of anterior prostatic lobes in the Saharan gerbil, Gerbillus tarabuli

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Annales d'endocrinologie Pub Date : 2025-06-01 DOI:10.1016/j.ando.2025.101749

Arezki Kheddache , Yamina Zatra , Kamilia Henna , Naouel Aknoun , Salima Charallah , Zaina Amirat , Farida Khammar

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引用次数: 0

Abstract

Introduction

This study analyses the effects of seasonal variations, castration and testosterone treatment on the anterior prostatic lobes of the Saharan gerbil (Gerbillus tarabuli).

Materials and methods

This rodent was captured in the Béni-Abbés region (30°7’N, 2°10’W; Algeria) during the resting period in autumn and the testicular activity period in spring. Castration and replacement treatment were also carried out in the spring.

Results and discussion

Castration and the decline in testosterone levels during the period of sexual rest induce atrophy of the anterior prostatic lobes. Histological and morphometric alterations are observed, characterised by increased fibromuscular stromal growth and epithelial regression. The heights of the epithelial cells and supranuclear zone are significantly reduced.

The weight of the anterior prostatic lobes is restored in the spring and after testosterone treatment of castrated animals. Testosterone treatment leads to the reappearance of the histological images observed in gonadally active animals, including a poorly developed fibromuscular wall and the mucosa developing very long epithelial folds which sink into the centre of a very wide lumen filled with secretions.

Conclusion

Further studies are required to provide a more comprehensive understanding of the functions and regulation of the prostatic lobes in the Saharan gerbil Gerbillus tarabuli.

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季节变化、去势和睾酮治疗对撒哈拉沙鼠前列腺前叶体重和组织形态学的影响

本研究分析了季节变化、阉割和睾酮治疗对撒哈拉沙鼠前列腺前叶的影响。材料与方法该鼠捕获于bb3 - abb3地区(30°7′n, 2°10′w；阿尔及利亚)在秋季休息期和春季睾丸活动期。去势和替代治疗也在春季进行。结果与讨论去势及性休息期间睾酮水平下降可引起前列腺前叶萎缩。观察到组织学和形态学改变，特征是纤维肌肉间质生长增加和上皮退化。上皮细胞高度和核上区高度明显降低。去势动物在春季和睾酮治疗后，前列腺前叶的重量恢复。睾酮治疗导致在性腺活动动物中观察到的组织学图像重现，包括发育不良的纤维肌肉壁和发育很长的上皮皱褶的粘膜，这些皱褶沉降到充满分泌物的非常宽的管腔的中心。结论撒哈拉沙鼠前列腺叶的功能及其调控机制有待进一步深入研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales d'endocrinologie 医学-内分泌学与代谢

CiteScore

4.40

自引率

6.50%

发文量

311

审稿时长

50 days

期刊介绍： The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.