Cutaneous sarcoidosis beyond the skin: Exploring endocrine comorbidities

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Annales d'endocrinologie Pub Date : 2025-06-01 DOI:10.1016/j.ando.2025.101747

Mohamed Amine Fouad , Nesrine Ben Salah , Mouna Korbi , Yousra Soua , Asma Mabrouk , Hichem Bel Hadj Ali , Jameleddine Zili

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Abstract

Introduction

Sarcoidosis is a chronic systemic inflammatory disease characterized by tissue infiltration of non-caseating granulomas. This study aims to identify endocrine disorders associated with sarcoidosis and determine their frequency in cutaneous sarcoidosis.

Materials and methods

A retrospective study was conducted between 2017 and 2025, including all patients followed for cutaneous sarcoidosis. The study included 11 patients, all female, with a mean age of 65.4 years (range: 57–73 years).

Results and discussion

Five cases presented with associated endocrinopathies: diabetes mellitus in 3 cases (2 with type 2 diabetes and 1 with type 1 diabetes), hypothyroidism in 1 case, and dyslipidemia in 1 case. The localization was cutaneous in all cases, pulmonary in 4 cases, hepatic in 1 case, and ophthalmological in 1 case. Treatment involved oral corticosteroids in 10 patients, while 1 patient received hydroxychloroquine due to isolated cutaneous involvement. The association between cutaneous sarcoidosis and endocrinopathies is rarely reported in the literature. Potential mechanisms include a direct effect on endocrine glands, shared pathophysiological pathways, or the effects of treatment, particularly corticosteroids.

Conclusion

This study highlights the importance of screening for endocrine comorbidities in patients with cutaneous sarcoidosis to optimize management. In conclusion, although endocrinopathies are uncommon, they can accompany cutaneous sarcoidosis. Their identification requires clinical vigilance and a multidisciplinary approach to improve overall patient care.

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皮肤以外的皮肤结节病：探讨内分泌合并症

结节病是一种以非干酪化肉芽肿组织浸润为特征的慢性全身性炎症性疾病。本研究旨在鉴别与结节病相关的内分泌紊乱，并确定其在皮肤结节病中的发病率。材料与方法回顾性研究2017 - 2025年所有皮肤结节病患者。研究纳入11例患者，均为女性，平均年龄65.4岁（范围：57-73岁）。结果与讨论5例伴有内分泌病变：糖尿病3例（2型糖尿病2例，1型糖尿病1例），甲状腺功能减退1例，血脂异常1例。所有病例均为皮肤定位，肺定位4例，肝定位1例，眼定位1例。10例患者接受口服皮质类固醇治疗，1例患者因孤立性皮肤受累接受羟氯喹治疗。皮肤结节病与内分泌疾病之间的关系在文献中很少报道。潜在的机制包括对内分泌腺的直接影响，共同的病理生理途径，或治疗的影响，特别是皮质类固醇。结论本研究强调了筛查皮肤结节病患者内分泌合并症对优化治疗的重要性。总之，虽然内分泌病变并不常见，但它们可以伴随皮肤结节病。他们的识别需要临床警惕和多学科的方法来改善患者的整体护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales d'endocrinologie 医学-内分泌学与代谢

CiteScore

4.40

自引率

6.50%

发文量

311

审稿时长

50 days

期刊介绍： The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.