卵巢间质囊肿:绝经后妇女被低估的男性化疾病。

IF 2.9 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Ons Boudaouara , Anis Sellami , Pascal Roger
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引用次数: 0

摘要

卵巢间质增生是一种罕见的非肿瘤性卵巢疾病,导致雄激素分泌过多和男性化。我们报告两例卵巢间质囊肿在绝经后妇女。两人均有男性化症状,血清睾酮水平高。盆腔成像显示卵巢大小正常或增大。卵巢静脉采样进行了一个病人,发现一个从左到右雄激素浓度梯度。两名妇女都接受了一线双侧卵巢切除术。病理发现双侧卵巢间质囊肿。术后,临床和生物高雄激素症在几个月内消退。囊肿过厚是一种良性的男性化状况,几乎总是累及两个卵巢。许多男性化疾病,尤其是产生雄激素的肿瘤,在考虑这种诊断之前必须排除。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ovarian stromal hyperthecosis: An underestimated virilizing disorder in postmenopausal women
Ovarian stromal hyperthecosis is an uncommon non-neoplastic ovarian disorder resulting in excessive androgen production and virilization. We report two cases of ovarian stromal hyperthecosis in postmenopausal women. Both complained of symptoms of virilization, with high serum testosterone levels. Pelvic imaging showed homogenous ovaries of normal or increased size. Ovarian venous sampling was performed in one patient and found a left-to-right androgen concentration gradient. Both women underwent first-line bilateral oophorectomy. Pathology found bilateral ovarian stromal hyperthecosis. Postoperatively, clinical and biological hyperandrogenism resolved within few months. Hyperthecosis is a benign virilizing condition almost always involving both ovaries. Numerous virilizing diseases, and especially androgen-producing neoplasms, have to be ruled out before considering this diagnosis.
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来源期刊
Annales d'endocrinologie
Annales d'endocrinologie 医学-内分泌学与代谢
CiteScore
4.40
自引率
6.50%
发文量
311
审稿时长
50 days
期刊介绍: The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.
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