孕妇对羟基苯甲酸酯暴露概况及其与甲状腺激素水平变化的关系。

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Annales d'endocrinologie Pub Date : 2025-06-13 DOI:10.1016/j.ando.2025.101801

Abderrezak Khelfi , Asma Idjeraoui , Hadjer Ouarzidini , Kahina Aksas , Mohamed Makrelouf , Mohamed Cherifi , Mohamed Azzouz

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引用次数: 0

摘要

对羟基苯甲酸酯被广泛怀疑是内分泌干扰物。妊娠期暴露于此可能干扰甲状腺激素稳态，对神经发育和胎儿生长产生不良影响。本研究旨在评估孕妇接触对羟基苯甲酸酯及其与妊娠期间甲状腺激素水平变化的可能关联。还调查了接触源与内源性对羟基苯甲酸酯浓度之间的联系。一项描述性研究包括384名孕妇。电化学发光法测定甲状腺激素和促甲状腺激素（TSH）。采用LC-MS/MS检测对羟基苯甲酸甲酯（MP）、对羟基苯甲酸乙酯（EP）和对羟基苯甲酸丙酯（PP）。几乎所有孕妇都有对羟基苯甲酸酯类药物(MP: 96.9%；EP: 89.3%;PP: 94.5%)，在不同范围内(MP: 36.633±39.849；Ep: 9.721±15.655；Pp: 22.109±20.722)。尿中PP浓度与血浆TSH和游离甲状腺素（FT4）水平呈显著负相关。暴露源分析显示，尿中EP水平与暴露于面部护理产品和防晒霜有显著关联。这项研究强调了对羟基苯甲酸酯暴露的惊人速度，它可能对孕妇的甲状腺激素水平产生有害影响，从而对胎儿神经发育产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Paraben exposure profiles in pregnant women and association with changes in thyroid hormone levels

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Paraben exposure profiles in pregnant women and association with changes in thyroid hormone levels

Parabens are widely suspected to be endocrine disruptors. Exposure during pregnancy may interfere with thyroid hormone homeostasis, resulting in adverse effects on neurodevelopment and fetal growth. This study aimed to assess pregnant women's exposure to parabens and possible associations with changes in thyroid hormone levels during pregnancy. Links between exposure sources and endogenous paraben concentrations were also investigated. This descriptive study included 384 pregnant women. Thyroid hormones and thyroid-stimulating hormone (TSH) were measured on electrochemiluminescence. Parabens (methylparaben [MP], ethylparaben [EP] and propylparaben [PP]) were detected on LC-MS/MS. Parabens were found in almost all pregnant women (MP: 96.9%; EP: 89.3%; PP: 94.5%), at varying ranges of μg/g creatinine (MP: 36.633 ± 39.849; EP: 9.721 ± 15.655; PP: 22.109 ± 20.722). There were significant negative associations between urinary concentrations of PP and plasma levels of TSH and free thyroxine (FT4). Analysis of exposure sources revealed significant associations of urinary levels of EP with exposure to facial care products and sunscreens. This research highlights the alarming rate of exposure to parabens, which may have deleterious effects on thyroid hormone levels in pregnant women, with consequent repercussions on fetal neural development.

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来源期刊

Annales d'endocrinologie 医学-内分泌学与代谢

CiteScore

4.40

自引率

6.50%

发文量

311

审稿时长

50 days

期刊介绍： The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.