5G电磁场作用下幼年大鼠甲状腺组织形态学研究

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Annales d'endocrinologie Pub Date : 2025-06-01 DOI:10.1016/j.ando.2025.101755

Mathilde Ramelet , Lise Ronger , Abdallah Al-Salameh , Amandine Pelletier , Rachel Desailloud , Chandreshwar Seewooruttun

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引用次数: 0

摘要

5g网络部署提出了这些电磁场对健康影响的问题。它们对热调节的影响是一种“冷反应”类型。在暴露于900兆赫的大鼠中，尾部血管收缩被诱导，行为倾向于温暖的隔间。下丘脑-垂体-甲状腺轴参与产热：对寒冷的反应，甲状腺活动增加，刺激产热。目的评价5G暴露后甲状腺活性。方法将10只3周龄雄性Wistar大鼠随机分为2周3.5 GHz和1.5 V/m 5G暴露组(5G组；N = 5)和无暴露(对照组；n = 5)。献祭后，取甲状腺进行组织形态学测定。测定甲状腺卵泡和胶体面积，评估甲状腺激活指数（TAI：卵泡与胶体面积之比）。结果5G组卵泡和胶体面积显著增大(2729 μm2 vs 2444 μm2, P = 0.0063；1317 μm2 vs 1015 μm2, P = 0.0027)， TAI显著降低（5.62 vs 7.07, P <0.001）。这些结果提示甲状腺功能减退。有5G效应，组织形态测量显示甲状腺功能减退，提示机制不同于潜在的冷反应。电磁场对甲状腺功能的影响以前有过报道，但根据暴露类型的不同，结果是不一致的。结论tsh和甲状腺激素检测可加强对甲状腺功能的评估。需要进一步的研究来探索潜在的机制。

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Histomorphometric study of thyroid tissue in juvenile rats exposed to 5G electromagnetic fields

Introduction

5G network deployment raises the issue of the health impact of these electromagnetic fields. Their effect on thermal regulation is of a “cold reesponse” type. In rats exposed to 900 MHz, vasoconstriction was induced in the tail, with behavioral preference for warmer compartments. The hypothalamo-pituitary-thyroid axis is involved in thermogenesis: in response to cold, thyroid activity increases, stimulating heat production.

Objective

To assess thyroid activity after 5G exposure.

Method

Ten 3-week-old male Wistar rats were randomized between 2 weeks’ 5G exposure at 3.5 GHz and 1.5 V/m (5G group; n = 5) and no exposure (controls; n = 5). After sacrifice, the thyroid gland was harvested for histomorphometry. Thyroid follicle and colloid areas were measured and the thyroid activation index (TAI: ratio of follicle to colloid area) was assessed.

Results

Follicle and colloid areas were significantly greater in 5G (2729 μm² vs 2444 μm², P = 0.0063; and 1317 μm² vs 1015 μm², P = 0.0027 respectively) and TAI was significantly lower (5.62 vs 7.07, P <0.001). These results indicate thyroid hypoactivity.

Discussion

There was a 5G effect, with histomorphometry demonstrating thyroid hypoactivity, suggesting mechanisms different from those underlying cold response. Impact of electromagnetic fields on thyroid function was previously reported, but results were heterogeneous and discordant depending on the type of exposure.

Conclusion

TSH and thyroid hormone assays are underway to reinforce assessment of thyroid function. Further studies are needed to explore the underlying mechanisms.

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来源期刊

Annales d'endocrinologie 医学-内分泌学与代谢

CiteScore

4.40

自引率

6.50%

发文量

311

审稿时长

50 days

期刊介绍： The Annales d''Endocrinologie, mouthpiece of the French Society of Endocrinology (SFE), publishes reviews, articles and case reports coming from clinical, therapeutic and fundamental research in endocrinology and metabolic diseases. Every year, it carries a position paper by a work-group of French-language endocrinologists, on an endocrine pathology chosen by the Society''s Scientific Committee. The journal is also the organ of the Society''s annual Congress, publishing a summary of the symposia, presentations and posters. "Les Must de l''Endocrinologie" is a special booklet brought out for the Congress, with summary articles that are always very well received. And finally, we publish the high-level instructional courses delivered during the Henri-Pierre Klotz International Endocrinology Days. The Annales is a window on the world, keeping alert clinicians up to date on what is going on in diagnosis and treatment in all the areas of our specialty.