Russian Journal of General Chemistry最新文献_第8页

Sulfonated Biochar Derived from Eucalyptus Bark as Natural Catalyst in the Biginelli Reaction 桉树皮磺化生物炭作为Biginelli反应的天然催化剂

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224613048

K. Bouafina, F. Belferdi, F. Bouremmad

引用次数: 0

Targeted Breast Cancer Combat: The Pioneering Role of Hesperidin-Infused pH and Thermosensitive Nanoparticles 靶向乳腺癌的战斗：橙皮苷注入pH和热敏纳米颗粒的先锋作用

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224611864

E. Küçük, M. Yıldırım, Ö. Acet, V. Karakoç, S. Yalın

{"title":"Targeted Breast Cancer Combat: The Pioneering Role of Hesperidin-Infused pH and Thermosensitive Nanoparticles","authors":"E. Küçük, M. Yıldırım, Ö. Acet, V. Karakoç, S. Yalın","doi":"10.1134/S1070363224611864","DOIUrl":"10.1134/S1070363224611864","url":null,"abstract":"This study aimed to improve the bioavailability and increase the therapeutic efficacy of Hes against breast cancer by using pH and temperature-sensitive smart polymeric nanoparticles. Poly(2-hydroxyethyl methacrylate) (pHEMA) is a synthetic polymer composed of HEMA monomers, suitable for medical applications due to its biocompatibility and cytocompatibility. Vinyl imidazole and poly(N-isopropylacrylamide) copolymers were used to impart pH sensitivity and temperature-sensitive properties to the pHEMA polymer, respectively. Both non-loaded and hesperidin-loaded smart nanoparticles (HesSNPs) were characterized by FTIR. The particle size and size distribution of HesSNPs were determined by dynamic light scattering analysis. Scanning electron microscopy was used to determine morphological characterization. Additionally, the effects of HesSNPs on cell proliferation, apoptosis, and cell cycle in breast cancer were also examined. The MTT assay was used to evaluate the cytotoxic effects of HesSNPs on MCF-7 cells at different concentrations (10–20 µM) for 24 h. It was found that MCF-7 cell proliferation in HesSNPs-1, HesSNPs-2, HesSNPs-3, and free hesperidin group decreased statistically significantly compared to the control group, depending on the dose (p < 0.05). The apoptotic effect was examined with the Annexin V-PI Staining Method in flow cytometry. The increase in the rate of apoptosis cells in the experimental groups was found to be statistically significant compared to the control group. Furthermore, it was determined that the nanoparticles induced apoptosis and increased the number of cells arrested in the G1 phase of the cell cycle.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 3","pages":"562 - 571"},"PeriodicalIF":0.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Activity Evaluation of Endogenous Hydrogen Sulfide Inhibitor of MRSA 内源性MRSA硫化氢抑制剂的设计、合成及活性评价

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224612638

W. F. He, J. X. Wang, P. Y. Gao, D. Q. Li, H. Jin, C. F. Liu, X. G. Liu

{"title":"Design, Synthesis, and Activity Evaluation of Endogenous Hydrogen Sulfide Inhibitor of MRSA","authors":"W. F. He, J. X. Wang, P. Y. Gao, D. Q. Li, H. Jin, C. F. Liu, X. G. Liu","doi":"10.1134/S1070363224612638","DOIUrl":"10.1134/S1070363224612638","url":null,"abstract":"Eighteen indole target compounds were synthesized from 3-(6-bromo-3-indolyl)propionic acid. The chemical structures were determined by 1H NMR, 13C NMR, and HRMS. Bioactivity assays revealed that 3-(6-bromo-3-indolyl)-N-(3-fluorophenyl)propenamide exhibited the most potent inhibitory effect on methicillin-resistant Staphylococcus aureus (MRSA) endogenous H2S at a concentration of 40 μM, with an inhibitory rate of 80.2±0.92%. The results of antibacterial experiments showed that co-administering partial target compounds with oxacillin sodium reduced the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of MRSA by 50% when compared to oxacillin sodium alone. Further studies revealed that the synergistic antimicrobial mechanism is closely related to the Fenton reaction. The results of the cytotoxicity assay showed that 3-(6-bromo-3-indolyl)-N-(4-chlorobenzyl)propenamide had the least inhibitory effect on BEAS-2B cells. The experimental results of this study may provide references and ideas for the treatment of MRSA infection.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 3","pages":"606 - 619"},"PeriodicalIF":0.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, Antifungal, and Nematocidal Activities of Novel Pyrimidine Derivatives Incorporating an 1,1,2-Trifluoro-1-butene Moiety 含有1,1,2-三氟-1-丁烯片段的新型嘧啶衍生物的设计、合成、抗真菌和杀线虫活性

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S107036322461264X

Yan-Ling Ren, Ling-Ling Xiao, Tao Wang, Hai-Yan Wang, Shou-Mei Wan, Lu Yu, Pei Li

{"title":"Design, Synthesis, Antifungal, and Nematocidal Activities of Novel Pyrimidine Derivatives Incorporating an 1,1,2-Trifluoro-1-butene Moiety","authors":"Yan-Ling Ren, Ling-Ling Xiao, Tao Wang, Hai-Yan Wang, Shou-Mei Wan, Lu Yu, Pei Li","doi":"10.1134/S107036322461264X","DOIUrl":"10.1134/S107036322461264X","url":null,"abstract":"In this study, a series of novel pyrimidine derivatives incorporating an 1,1,2-trifluoro-1-butene moiety were synthesized and their structures were confirmed by 1H NMR, 13C NMR, and HRMS. The bioassay results demonstrate that 4-methyl-2-[(3,4,4-trifluorobut-3-en-1-yl)thio]-6-(trifluoromethyl)pyrimidine exhibits comparable in vitro antifungal activity against Aspergillus niger (64.55 and 48.85%, respectively) at concentrations of 100 and 50 μg/mL when compared to Prochloraz. Additionally, 4-methyl-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-6-(trifluoromethyl)pyrimidine demonstrates superior nematocidal activity against Caenorhabditis elegans at concentrations of 100 and 50 μg/mL after 48 h with corrected mortality rates of 89.65 and 79.47%, respectively, surpassing those observed for ethoprophos. To the best of our knowledge, this study presents the first report on the synthesis and antifungal and nematocidal activities of novel pyrimidine derivatives incorporating an 1,1,2-trifluoro-1-butene moiety.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 2","pages":"511 - 517"},"PeriodicalIF":0.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Assisted Facile Synthesis of 1,2-Benzisoxazoles, Isoxazoloquinolines, and Isothiazoloquinolines in [BMIM(SO2Cl)][OTs] Ionic Liquid as a Recyclable System [BMIM(SO2Cl)][OTs]离子液体中微波辅助快速合成1,2-苯并异恶唑、异恶唑喹啉和异噻唑喹啉

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S1070363224611943

I. Jamadar, R. B. Manami, S. Kurahatti, A. Anchi, V. Jadhav, R. G. Kalkhambkar, M. Kurkuri, M. S. Refat, A. M. Alsuhaibani

引用次数: 0

Experimental and Theoretical Studies for Noncovalent Interactions Analysis of 2-Mercaptopyrimidine Derivative and Their Antimicrobial Activities 2-巯基嘧啶衍生物非共价相互作用分析及其抗菌活性的实验与理论研究

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S1070363224611773

A. Jaiswal, M. Mishra, J. Singh, R. K. Upadhyay, A. K. Pal, R. Kumar

引用次数: 0

Tripodal Tricarboxylic Acids on the Triphenylphosphine Oxide Platform 氧化三苯基膦平台上的三足三羧酸

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S1070363224612043

T. V. Baulina, I. Yu. Kudryavtsev, M. P. Pasechnik, A. G. Matveeva, A. V. Vologzhanina, V. K. Brel

引用次数: 0

Tetrakis-benzimidazoles as Tetradentate to Octadentate Ligands: Their Properties, Applications, and Metal Complexes (A Review) 四聚苯并咪唑作为四齿到八齿配体：性质、应用和金属配合物（综述）

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S107036322461216X

A. Tavman

{"title":"Tetrakis-benzimidazoles as Tetradentate to Octadentate Ligands: Their Properties, Applications, and Metal Complexes (A Review)","authors":"A. Tavman","doi":"10.1134/S107036322461216X","DOIUrl":"10.1134/S107036322461216X","url":null,"abstract":"Tetrakis-benzimidazoles are tetrapodal compounds with multidentate ligand properties, including at least tetradentate provided by the C=N nitrogen atoms in each benzimidazole unit, and they can be obtained in their many derivatives. There are also tetrakis-benzimidazole derivatives that contain atoms such as N and O in the bridge units and thus exhibit various donor properties up to octadentate. Because of these properties, they are similar to EDTA (ethylenediamminetetraacetic acid) which is a medication used in the management and treatment of heavy metal toxicity, and attract the attention of researchers. The applications of tetrakis-benzimidazole derivatives and various metal complexes in many fields such as corrosion inhibitor, catalyst, enzyme inhibitor, superoxide dismutase, catalase activity, superoxide oxidase, DNA affinity, determination of H2O2, were investigated. In this study, a comprehensive review was conducted on tetrakis-benzimidazoles: their synthesis routes, properties, various metal complexes, features and application areas have been reviewed and compiled in order to be useful for researchers who will work in this field.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 2","pages":"436 - 490"},"PeriodicalIF":0.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico ADME, DFT, and Antiproliferative Activity of Pyrazole-based Pyrimidinethione, Triazolethione, and Thiadiazolopyrimidine Derivatives 吡唑基嘧啶硫酮、三唑硫酮和噻二唑嘧啶衍生物的ADME、DFT和抗增殖活性

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S1070363224612146

S. K. Ramadan, S. M. Gomha, E. A. E. El-Helw

引用次数: 0

Synthesis, Structure, and Fluorescence Property of a Lead Two-dimensional Coordination Polymer Constructed by Cyclohexenedicarboxylate Ligand 环己二羧酸配体构建的铅二维配位聚合物的合成、结构和荧光性质

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S1070363224611979

Y.-T. Guo, Y. Wang, L. Guan, H.-Z. Jin, D. Zhao, Y.-X. Li, X.-Y. Hao

{"title":"Synthesis, Structure, and Fluorescence Property of a Lead Two-dimensional Coordination Polymer Constructed by Cyclohexenedicarboxylate Ligand","authors":"Y.-T. Guo, Y. Wang, L. Guan, H.-Z. Jin, D. Zhao, Y.-X. Li, X.-Y. Hao","doi":"10.1134/S1070363224611979","DOIUrl":"10.1134/S1070363224611979","url":null,"abstract":"The reaction of dicarboxylate ligand, cis-4-cyclohexene-2-dicarboxylic acid (H2ccdca), with Pb(II) in solvothermal condition resulted in the formation of a new coordination polymer (CP) i. e., [Pb(ccdca)]n. Single crystal X-ray study reveals that this coordination polymer features a two-dimensional network whereas ccdca2– anions adopt their carboxylate groups to link with five neighboring Pb centers in µ1:η1:η1 and µ3:η2:η1 coordination modes. The ccdca2– ligands display trans-conformation and link with Pb centers to form an interesting 4,4-connected topological network with point symbol of {43·63}. In addition, the photoluminescent spectra indicate that free H2ccdca ligand and [Pb(ccdca)]n exhibit the emission maxima at 412 and 512 nm and emit blue and green luminescence at room temperature, respectively. Compound [Pb(ccdca)]n displays a red-shift of 100 nm in emission by comparison with free H2ccdca ligand, with enhanced emission band, which is attributed to the chelation of ligand to the Pb(II), increasing rigidity and reducing energy loss via nonradiative decay in the excited state.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 2","pages":"428 - 435"},"PeriodicalIF":0.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0