Russian Journal of General Chemistry最新文献

{"title":"Urease Inhibition Activity Studies of Novel Azabenzimidazole-Derived Compounds","authors":"G. Akyüz,&nbsp;E. Menteşe","doi":"10.1134/S1070363224090214","DOIUrl":"10.1134/S1070363224090214","url":null,"abstract":"<p>A new series of azabenzimidazole compounds was synthesized and characterized with spectral methods such as IR, ¹H NMR, ¹³C NMR and elemental analysis. The target compounds were screened for urease, and acetylcholinesterase inhibitory activities. The synthesized azabenzimidazole containing thiosemicarbazide and oxadiazole moieties showed antiurease activity. 2,2′-[(6-Bromo-2-oxo-1<i>H</i>-imidazo[4,5-<i>b</i>]pyridine-1,3-diyl)bis(1-oxoethane-2,1-diyl)]bis(<i>N</i>-4-nitrophenylhydrazinecarbothioamide) has the best inhibition result with IC₅₀ = 15.80±0.40 µg/mL (15.75±0.15 µg/mL for thiourea).</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2432 - 2437"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reaction of 6Н-5-(4-Fluorophenyl)-3-(2-pyridyl)-1,2,4-triazine with 4,5-Difluoro-1,2-dehydrobenzene","authors":"A. Rammohan,&nbsp;A. P. Krinochkin,&nbsp;Yu. M. Sayfutdinova,&nbsp;Y. K. Shtaitz,&nbsp;S. S. Potapova,&nbsp;P. A. Slepukhin,&nbsp;V. S. Gaviko,&nbsp;D. S. Kopchuk,&nbsp;G. V. Zyryanov,&nbsp;O. N. Chupakhin","doi":"10.1134/S1070363224090056","DOIUrl":"10.1134/S1070363224090056","url":null,"abstract":"<p>The reaction of C⁶-unsubstituted 5-aryl-3-(2-pyridyl)-1,2,4-triazine with generated <i>in situ</i> difluoroaryne intermediate (4,5-difluoro-1,2-dehydrobenzene), previously unused for this aim, was studied. New transformations of the 1,2,4-triazine nucleus were discovered, which lead, along with the domino transformation product (10-(1,2,3-triazole-3-yl)pyrido[1,2-<i>a</i>]indole) natural for this transformation, to the formation of unexpected products, namely 1,3,5-tris-substituted 1,6-dihydro-1,2,4-triazin-6-ol and 1<i>H</i>-1,2,4-triazole. The structure of the products was confirmed by physicochemical methods, including X-ray diffraction analysis.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2255 - 2263"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reaction of 6-Methylpyridin-2-ylphosphine with Benzaldehyde and p-Toluidine: A Pathway to Acyclic Aminomethylphosphine Oxides with Carbon-Substituted PCHN Fragments","authors":"A. V. Kurenkov,&nbsp;I. R. Dayanova,&nbsp;I. A. Rychkova,&nbsp;O. E. Naumova,&nbsp;D. R. Islamov,&nbsp;I. D. Strelnik,&nbsp;A. A. Karasik","doi":"10.1134/S1070363224090068","DOIUrl":"10.1134/S1070363224090068","url":null,"abstract":"<p>The reaction of 6-methylpyridin-2-ylphosphine with benzaldehyde and <i>p</i>-toluidine was investigated. This reaction leads to the formation of three isomers of acyclic aminomethylphosphine oxide with a moderate yield. The structures of the compounds were confirmed by NMR and IR spectroscopy data. It was shown that the reaction results in the formation of three isomers of acyclic aminomethylphosphine. One of the isomers was isolated in a crystalline form suitable for the single crystal X-ray diffraction analysis. According to the XRD data, the isomer is crystallized as dimers formed by N–H···O hydrogen bonds.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2264 - 2270"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Aramid Fiber Processing with Nanotubes on Shear Strength at the Matrix/Fiber Interface","authors":"M. S. Shebanov,&nbsp;V. G. Bova,&nbsp;L. B. Shiyanova,&nbsp;V. B. Ivanov","doi":"10.1134/S1070363224090330","DOIUrl":"10.1134/S1070363224090330","url":null,"abstract":"<p>The strengths of the complex thread and single filaments of the copolymer aramid fiber of the Rusar-S brand produced by JSC Research and Production Enterprise “Termoteks” (Russia, Moscow region) and microplastics based on epoxy resin (KDA brand) and prepared using the aramid fiber were determined. It was found that the treatment of the fiber surface during its formation using a suspension of multilayer carbon nanotubes produced by NanoTechCenter LLC (Russia, Tambov,) leads to an increase in the strength of the thread, determined at a clamping length of 70 mm, by 4.4%. The increase in the strength of microplastics under the same conditions was 8.2%. Estimated on the basis of the analysis of the dependence of a single filament strength on the clamping length, the value of the critical fiber length after treatment with nanotubes decreased from 0.59 to 0.43 mm, and the strength increased by 28%, from 4.98 to 6.38 GPa. This leads to an increase in the tensile strength when the matrix is shifted at the interface with aramid fiber, by 67.7%, from 72.8 to 122 MPa. The results obtained indicate the possibility of a significant increase in the strength of the composite material when using aramid fiber modified with multilayer nanotubes. It is noted that the correct application of the correlations linking the tensile strength limits of a complex thread and a microplastic made therefrom is possible only at the approximation of the experimental data using the Weibull–Gnedenko distribution. The hypothesis of compliance of experimental data for aramid fibers treated with nanotubes with the Weibull–Gnedenko distribution was verified by means of nonparametric statistics methods. Electron microscopy has shown that the fiber surface becomes rougher after treatment with nanotubes, which should lead to enhanced adhesive interaction with the matrix.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2551 - 2554"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetylcholine Hydrolysis and Antidote Delivery Using a Histidine-Resorcinarene-based Nanocontainer","authors":"E. E. Mansurova,&nbsp;A. A. Maslennikov,&nbsp;A. P. Lyubina,&nbsp;A. Sapunova,&nbsp;A. D. Voloshina,&nbsp;I. R. Nizameev,&nbsp;M. K. Kadirov,&nbsp;R. R. Fazleeva,&nbsp;V. V. Yanilkin,&nbsp;A. Y. Ziganshina,&nbsp;I. S. Antipin","doi":"10.1134/S1070363224090111","DOIUrl":"10.1134/S1070363224090111","url":null,"abstract":"<p>A new nanocarrier was developed for the delivery of an antidote for poisoning with organophosphorus compounds. The nanocarrier acts as an artificial esterase, hydrolyzing acetylcholine and releasing the antidote (atropine) when acetylcholine level is high. The nanocarrier was made using histidine-containing resorcinarene as a building block. Histidine-resorcinarene was preorganized in a microemulsion media and then polymerized with phenylboronic acid, which acts as a linker between the resorcinarene molecules. Antidote (atropine) was incorporated into the nanocarrier with an encapsulation efficiency of 52.2%. At a neutral pH of 7.4, the nanocarrier hydrolyzes acetylcholine to choline and acetic acid. The acid triggers dissociation of the boronate bonds to dissociate, resulting in nanocarrier degradation and the release of 64.4% of the antidote. Transmission electron microscopy (TEM), dynamic and static light scattering (DLS and SLS, respectively), and IR spectroscopy were utilized to characterize the structure of the nanocarriers. Cyclic voltammetry and NMR spectroscopy were employed to evaluate its ability to hydrolyze acetylcholine. Through fluorescence and NMR spectroscopy, it was demonstrated that the nanocarrier could release substrates (fluorescein and atropine) in in response to the presence of acetylcholine.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2298 - 2309"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S1070363224090111.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Microorganisms on the Electrical Conductivity of Composite Materials Under Extreme Conditions","authors":"I. G. Kalinina,&nbsp;S. A. Semenov,&nbsp;V. B. Ivanov","doi":"10.1134/S1070363224090305","DOIUrl":"10.1134/S1070363224090305","url":null,"abstract":"<p>It has been established that the variation in the conductance of insulation made with materials of various chemical nature and physical structure (polyvinyl chloride plastic compound and varnished cambric) with a short-term exposure to a mold fungus has an S-shaped character. The unambiguous correlation of the induction period, the stage of rapid increase and the time to reach the quasi-stationary level of conductance with the induction period, the stage of rapid growth, the time to reach the maximum amount of biomass on the surface of the material is due to the sorption by isolation of the metabolic products of the mold fungus. The variation in conductance at short times of exposure to microorganisms (~ 1 month) is reversible. Removal of microorganisms from the surface leads to a decrease in conductance to its original level. With their longer exposure (~ 1 year), the change in conductance may become irreversible as a result of the biochemical decomposition of insulation components, in particular, dialkyl phthalates - polyvinyl chloride plasticizers. Features of the processes of changes in conductance are due to the duration of the growth of microorganisms, the nature of materials and their components. The growth of microorganisms depends primarily on temperature and humidity conditions. For materials with high water absorption (varnished cambric), the most important external factor is temperature, and for materials with low water absorption (polyvinyl chloride) – relative humidity.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2534 - 2537"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical Foundations, Models, and Calculations of the Compositions of Particulate-Filled Polymers with Different Types of Structures and Properties","authors":"I. D. Simonov-Emelyanov,&nbsp;K. I. Kharlamova","doi":"10.1134/S1070363224090342","DOIUrl":"10.1134/S1070363224090342","url":null,"abstract":"<p>For the first time, the theoretical foundations for building the structure of particulate-filled polymer composite materials (PFPCMs) are presented from the standpoint of joint examination of Shklovsky-de Gennes model ideas concerning the formation of the structure of dispersed fillers in space and, proposed by us, a generalized model, including the creation of free space, its filling with a polymer matrix (binder) and its functional division into three components: φ_p = θ + <i>B</i> + <i>M</i> (θ is the proportion of the polymer phase-matrix for the formation of an interlayer between the filler particles; <i>B</i> is the proportion of the polymer phase-matrix at the maximum packaging of the dispersed phase; <i>M</i> is the proportion of the polymer phase-matrices in boundary layers). Correlation dependences between the parameters of heterogeneity in space (lattice parameters: <i>Z</i> and <i>k</i>_pac) and the generalized parameter θ were established, all PNPCMs were classified according to the structural principle [structure type: DS—diluted, LFS—low-filled, MFS—medium-filled (MFS-1 and MFS-2) and HFS—highly filled dispersed systems]. Generalized (θ, <i>V</i>, <i>M</i>) and reduced parameters (θ/<i>V</i> and θ/<i>S</i>_<i>n</i>) are proposed to describe the structure of the PFPCMs. Experimental methods have been developed for determining the main parameter of a dispersed filler for constructing PFPCMs structures—the maximum packing (<i>k</i>_pac) and the maximum content of dispersed fillers (parameter φ_<i>m</i>) of different sizes. It is shown that the construction of all possible types of structures and compositions of PFPCMs should begin with HFS at the content of dispersed filler equal to φ_<i>m</i> (fixed starting point), similar to the construction of the stepped CHICHEN ITZA PYRAMID with the apex—HFS, the base—a polymer matrix (PM) and with steps—different types of structures (MFS-2, MFS-1, LFS and DS). The dependences of the physicochemical, rheological, physicomechanical, electrophysical, thermophysical characteristics of PFPCMs on the generalized and reduced parameters, as well as on the lattice parameters <i>Z</i> and <i>k</i>_pac of the dispersed filler are established, and it is shown that the type of structure and its parameters determine the properties of PFPCMs. The obtained dependencies for the first time made it possible to compare the characteristics of PFPCMs with the same types of structures, and not at a constant value of the content of the dispersed phase (φ_<i>f</i> = const), which is not correct. This concept is the basis for the creation of high-tech, high-strength, heat-conductive and heat-insulating, as well as electrically conductive, etc. PFPCMs. New theoretical provisions can be extended to the construction of structures of composite materials based on metal and ceramic matrices.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2555 - 2565"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graphene Oxide: Unveiling Its Chemistry and Its Emerging Applications (A Review)","authors":"M. L. Anantha Lekshmi,&nbsp;A. J. Prakash,&nbsp;R. J. Jerlin,&nbsp;K. R. Dinesh","doi":"10.1134/S1070363224090202","DOIUrl":"10.1134/S1070363224090202","url":null,"abstract":"<p>This review summarizes the intricate structural features and characterisation of graphene oxide (GO), as well as its many derivatives and wide-ranging uses. GO exhibits adaptability across a range of applications, including environmental remediation and biological purposes. The use of this material extends to both the fabrication of freestanding membranes and their incorporation into other composite systems. Gaining an in-depth understanding of the structure and features of GO is vital for effectively using its promise in many fields. Scientists constantly discover new uses and improve the techniques of creating it to boost its capabilities. GO, in environmental environments, facilitates and removing of pollutants as well as water purification. The biocompatibility and drug delivery characteristics of this substance are advantageous in the fields of medicine and biology. Furthermore, membranes based on graphene oxide are useful in filtering technologies. Systems that combine graphene oxide have improved mechanical, electrical, and thermal characteristics, which hold great potential for breakthroughs in the field of materials research. Overall, the complex and versatile character of GO highlights its significance in several disciplines and emphasises its reputation as a material with great promise.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2413 - 2431"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regularities of Obtaining Electrochromic WO3 Films at the Cathode Polarization of the Electrode","authors":"A. V. Shchegolkov,&nbsp;A. V. Shchegolkov,&nbsp;M. S. Lipkin,&nbsp;F. F. Komarov,&nbsp;I. D. Parfimovich","doi":"10.1134/S1070363224090329","DOIUrl":"10.1134/S1070363224090329","url":null,"abstract":"<p>In the article, electrochromic WO₃ films were obtained from 25, 100, and 200 mM peroxytungstic acid (PTA) solution. A chronoamperogram of the cathodic reduction of tungsten oxide (WO₃) through the stages of formation of a precursor film adsorbed on the surface of the ITO electrode and its subsequent staged reduction to WO₃ and side formation of soluble reaction products is presented. The material yield of the WO₃ film on ITO glass was within 50%, which is due to the parallel occurrence of side processes associated with hydrogen evolution and the reduction of tungsten complexes that were in the precipitation solution (WO₃ reduction scheme). In this case, it was taken into account that thin WO₃ films were the final product. The features of the synthesis of peroxytungstic acid have been studied. It has been shown that the reaction of W dissolution in 37% H₂O₂ proceeds exothermically. In this case, the reaction temperature reached 96°C within a few seconds, and its decline varied exponentially with the formation of reaction products. The dependence of the limiting current on the square root is obtained. The presented graphic dependence is characterized by linearity, while the beginning of the straight line does not coincide with the origin. The process of intercalation-deintercalation of protons (H⁺) (cathode-anode branches of CV) was a consequence of structural and reversible changes as a result of H⁺ intercalation. WO₃ films obtained by electrochemical (cathodic) deposition can be recommended as an electrode material for electrochromic devices (cathode) and as a material for electrochemical sensors. Another promising direction is the development of a wide band gap anode based on WO₃ for photovoltaic devices, which are energy efficient hydrogen generation systems.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2545 - 2550"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Activity of Azo Compounds (Mini-Review)","authors":"N. O. Sonin,&nbsp;D. M. Egorov","doi":"10.1134/S1070363224090019","DOIUrl":"10.1134/S1070363224090019","url":null,"abstract":"<p>This mini-review summarizes the latest advances in the study of the anticancer activity of azo compounds. The data shows the high potential of this class of compounds, which allows us to determine the existing vectors of development in this area, and evaluate the effectiveness of the modifications of azo compounds. The review covers the period from 2006 to 2022.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2207 - 2233"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}