具有潜在生物活性的蓖麻油酸吡唑衍生物的合成

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI:10.1134/S1070363225602649

G. Y. Ishmuratov, M. P. Yakovleva, I. S. Nazarov, K. M. Saitov

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引用次数: 0

摘要

以天然蓖麻油为原料，建立了一种合成蓖麻油酸吡唑衍生物的有效方法。蓖麻油酸甘油三酯经酯交换成甲酯，氧化为酮衍生物，酸异构化得到一个e构型的α，β-不饱和酮，其与若干肼反应完成合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Potentially Biologically Active Pyrazole Derivatives of Ricinoleic Acid

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Synthesis of Potentially Biologically Active Pyrazole Derivatives of Ricinoleic Acid

An effective approach was developed for the synthesis of a number of pyrazole derivatives of ricinoleic acid, available from natural castor oil. Transesterification of the ricinoleic acid triglyceride to its methyl ester, oxidation to a keto derivative, and acid isomerization resulted in a single α,β-unsaturated ketone of the E-configuration, whose reaction with a number of hydrazides completed the synthesis.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.