Russian Journal of General Chemistry最新文献

Ecofriendly Synthesis, Biological Evaluation, and Molecular Docking Studies of a Novel N-[3-(Benzo[d][1,3]dioxol-5-yl]-1,8-naphthyridine Benzamide Derivatives and Phenyl-triazolo-[1,8]naphthyridine Scaffolds

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224611451

Sontireddy Surender Reddy, Kavati Shireesha, Kumara Swamy Jella

{"title":"Ecofriendly Synthesis, Biological Evaluation, and Molecular Docking Studies of a Novel N-[3-(Benzo[d][1,3]dioxol-5-yl]-1,8-naphthyridine Benzamide Derivatives and Phenyl-triazolo-[1,8]naphthyridine Scaffolds","authors":"Sontireddy Surender Reddy, Kavati Shireesha, Kumara Swamy Jella","doi":"10.1134/S1070363224611451","DOIUrl":"10.1134/S1070363224611451","url":null,"abstract":"An efficient and rapid synthetic method was developed for the construction of N-(1,8-naphthyridin-2-yl)benzamides and 9-aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridine derivatives via microwave irradiation, obtained in excellent yields. This approach offers significant advantages, including reduced reaction time, enhanced yields, improved product purity, minimal by-product formation, and low energy consumption. The synthesized compounds were evaluated for their in vitro antimicrobial activity against pathogenic strains, revealing remarkable activity for certain derivatives compared to standard clinical drugs. Among them 6-(benzo[d][1,3]dioxol-5-yl)-9-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine exhibited the highest antimicrobial activity among the series. In addition, molecular docking studies further supported the experimental findings, demonstrating strong binding affinities of the active compounds to the target protein via hydrogen bonding interactions. These interactions suggest the synthesized compounds exhibit a stable and effective binding mode, correlating with their observed antimicrobial properties.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 1","pages":"173 - 183"},"PeriodicalIF":0.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of (N,O)-Functionalized Phosphonates by Biotesting Methods

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224613310

L. G. Bakina, N. V. Mayachkina, A. G. Pilip, Yu. M. Polyak, A. O. Gerasimov, A. V. Egorova, I. E. Kolesnikov, A. A. Manshina, E. A. Gorbunova

{"title":"Study of (N,O)-Functionalized Phosphonates by Biotesting Methods","authors":"L. G. Bakina, N. V. Mayachkina, A. G. Pilip, Yu. M. Polyak, A. O. Gerasimov, A. V. Egorova, I. E. Kolesnikov, A. A. Manshina, E. A. Gorbunova","doi":"10.1134/S1070363224613310","DOIUrl":"10.1134/S1070363224613310","url":null,"abstract":"Photopharmacology is one of the most promising and rapidly developing branches of modern medicine, based on the control of the biological activity of compounds by the light effect. An urgent issue in the development of “smart drugs” (compounds with light-controlled biological activity) is the toxicological assessment of new synthesized substances, determining their safety for humans and animals. This study is related to investigation of toxic properties of vinyl phosphonates, diene compounds with ethyl and isopropyl substituents at the phosphonate group. To determine the toxicity, test organisms from various systematic groups have been used, such as daphnia, ciliates, and green unicellular algae, which makes it possible to obtain the most objective assessment of the considered substances. The performed study of the phosphonates has revealed the differences in the degree of their toxicity for the test organisms. Daphnia have turned out to be the most sensitive to the action of functionalized phosphonates, whereas the unicellular green algae have exhibited slightly lower sensitivity, and the ciliates have shown the least sensitivity to the synthesized agents. Based on experiments on daphnia, considered as the most sensitive test organisms, median lethal dose and and safe concentration of the phosphonates have been determined.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 1","pages":"114 - 124"},"PeriodicalIF":0.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Sodalite at Room Temperature for Enhanced Zn2+ Removal from Aqueous Solution

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224611761

X. Zhang, Q. Li, J. Niu, B. Yang

{"title":"Preparation of Sodalite at Room Temperature for Enhanced Zn2+ Removal from Aqueous Solution","authors":"X. Zhang, Q. Li, J. Niu, B. Yang","doi":"10.1134/S1070363224611761","DOIUrl":"10.1134/S1070363224611761","url":null,"abstract":"Sodalite products were synthesized with varying hydrogel Al2O3/SiO2 ratio by a hydrothermal route. The results revealed that spherical particles consisted of small crystallites were obtained after 10 h of room-temperature crystallization; while with the same hydrogel composition, the sample synthesized at 90°C for 10 h was large lepispherical particles. In compare with sample obtained at elevated temperature, sodalite crystals synthesized under room temperature exhibited better Zn2+ ions adsorption performance, and the maximum adsorption capacities were measured to be 51.2, 54.3, 57.1, and 61.6 mg/g for the sodalite synthesized with hydrogel Al2O3/SiO2 ratios of 0.43, 0.55, 0.68 and 0.84, respectively. The reasons would be attributed to its larger surface area, specific pore structure, along with more available active sites of adsorbent. Moreover, the adsorption isotherms and kinetics analysis displayed that Langmuir model and pseudo-second order model matched well with the adsorption processes. Sodalite products obtained under room temperature are potential adsorbents for the removal of Zn2+ as low-cost materials used for treating sewage in the future.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 1","pages":"229 - 238"},"PeriodicalIF":0.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Structure, and Catalytic Properties of Palladium(II) Complexes with Acetophenone Semicarbazone and Its Derivatives

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224612687

A. S. Igonin, E. I. Isaeva, R. I. Baichurin, S. V. Makarenko

引用次数: 0

Thermodynamics, Kinetics, and Mechanism of Luteolin Adsorption on Nickel-Doped Amino-Modified Silica

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224611797

X. Niu, D. Han, B. Zhang, X. He, Y. Zhang, Z. Yan

{"title":"Thermodynamics, Kinetics, and Mechanism of Luteolin Adsorption on Nickel-Doped Amino-Modified Silica","authors":"X. Niu, D. Han, B. Zhang, X. He, Y. Zhang, Z. Yan","doi":"10.1134/S1070363224611797","DOIUrl":"10.1134/S1070363224611797","url":null,"abstract":"N-[3-(Trimethoxysilyl)propyl]ethylenediamine, tetraethyl silicate, nickel acetate, and sodium hydroxide solution were reacted through using anhydrous ethanol as the solvent and heated in a water bath to synthesize nickel-doped amino-modified silica adsorbent material (NDAMS). The structure of NDAMS was characterized by utilizing XRD, BET, FTIR, and XPS. The thermodynamics, kinetics and mechanism of luteolin adsorption on NDAMS were examined. The results exhibit that NDAMS achieves a 94.69% adsorption efficiency for luteolin at 298 K, demonstrating excellent adsorption performance. As the temperature increases, the adsorption amount rises, which conforms to the Langmuir model. The adsorption process aligns with the pseudo-second-order kinetic model, with an enthalpy (ΔH) of 30.68 kJ/mol, entropy (ΔS) of 198.70 J/(mol K), and Gibbs free energy (ΔG) of –28.44 kJ/mol at 298 K. NDAMS may adsorb luteolin through a spontaneous, endothermic and monolayer chemisorption process, in which a bond is formed between the doped nickel atoms and the oxygen atoms in the luteolin’s phenolic hydroxyl group.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 1","pages":"239 - 252"},"PeriodicalIF":0.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, In Vitro Anticancer and ADMET Studies of Piperazine-Pyrazolo-Quinoxalin-2(1H)-one Conjugate as EGFR Targeting Agents

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224610366

M. Ferazoddin, Arshiya Banu Syeda, Asra Banu Syeda, G. Dasari, S. Bandari

{"title":"Design, Synthesis, In Vitro Anticancer and ADMET Studies of Piperazine-Pyrazolo-Quinoxalin-2(1H)-one Conjugate as EGFR Targeting Agents","authors":"M. Ferazoddin, Arshiya Banu Syeda, Asra Banu Syeda, G. Dasari, S. Bandari","doi":"10.1134/S1070363224610366","DOIUrl":"10.1134/S1070363224610366","url":null,"abstract":"A series of piperazine-pyrazolo-quinoxalin-2(1H)-one conjugate was synthesized and evaluated for their anticancer activity against two human breast cancer cell lines, such as MCF-7 and MDA-MB231 using erlotinib as a reference drug. The activity results showed that 1-{[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]methyl}-3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one, 1-{[3-(3,5-dimethoxyphenyl)-1H-pyrazol-5-yl]methyl}-3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one and 1-{[3-(3-methoxyphenyl)-1H-pyrazol-5-yl]methyl}-3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one exhibited higher activity as compared to standard drug. The tyrosine kinase EGFR inhibitory activity showed that 1-{[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]methyl}-3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one and 1-{[3-(3,5-dimethoxyphenyl)-1H-pyrazol-5-yl]methyl}-3-(4-methylpiperazin-1-yl)quinoxalin-2(1H)-one have higher inhibitory activity as compared to the standard drug erlotinib. Additionally, we performed in silico ADMET for the potent compounds. All the three compounds followed four filters (Lipinski rule, Ghose rule, Veber rule, Egan rule, and Muegge rule) that matched all four of the above-mentioned conditions, except Ghose rule.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 1","pages":"184 - 195"},"PeriodicalIF":0.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Secondary Amines of Bornylamine and Isobornylamine Containing a Saturated N-Heterocycle and Study of Their Antiviral Activity against Respiratory Syncytial Virus

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224613486

S. A. Tishchenko, A. S. Sokolova, O. I. Yarovaya, V. I. Krasnov, A. A. Shtro, A. V. Galochkina, A. M. Klabukov, D. N. Razgulyaeva, N. F. Salakhutdinov

引用次数: 0

Synthesis, Characterization, and In Vitro Anticancer Studies of New 1,8-Naphthyridine Substituted Schiff Base Derivatives and Their Molecular Docking 新型 1,8-萘啶取代席夫碱衍生物的合成、表征和体外抗癌研究及其分子对接

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224609062

K. Md, R. Domala

引用次数: 0

Synthesis and Analgesic Activity of Ureas and Imidazolidine-2,4,5-trione Derivatives Containing Adamantane and Monoterpene Fragments

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224612808

P. E. Rogozin, E. V. Suslov, A. Yu. Filippova, A. V. Pavlova, K. P. Volcho, N. F. Salakhutdinov

引用次数: 0

Approaches to the Synthesis of 1,2,4-Triazolo[4,3-a]pyrimidines (Mini-Review)

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI: 10.1134/S1070363224613322

A. S. Skrylkova, D. M. Egorov, A. V. Egorova, A. A. Manshina

引用次数: 0