E. A. Tishchenko, V. A. Lukina, M. G. Niyazov, L. V. Myznikov
{"title":"Synthesis and Some Properties of 5-Alkylsulfinyl- and 5-Alkylsulfonyl-1H-tetrazoles","authors":"E. A. Tishchenko, V. A. Lukina, M. G. Niyazov, L. V. Myznikov","doi":"10.1134/S1070363225601322","DOIUrl":"10.1134/S1070363225601322","url":null,"abstract":"<p>The reaction of 5-alkylsulfanyl-1<i>H</i>-tetrazoles with H<sub>2</sub>O<sub>2</sub> in acetonitrile under microwave activation conditions and in the presence of phosphomolybdic acid as a catalyst was studied. It was shown that 5-alkylsulfinyl- or 5-alkylsulfonyl-1<i>H</i>-tetrazoles were formed with good yields depending on temperature and oxidant concentration. The above compounds are stable in strongly acidic media and easily react with alcohols and unsaturated compounds to form 2-substituted 5-alkylsulfinyl- or 5-alkylsulfonyltetrazoles.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1192 - 1198"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ya-ping Tao, Qi-feng Jiang, Xin-Hui Zhang, Ri-qing Liu
{"title":"Effect of Fluorinated Substitution on the Properties of Phenylethylamine Derivatives: A Density Functional Theory Study","authors":"Ya-ping Tao, Qi-feng Jiang, Xin-Hui Zhang, Ri-qing Liu","doi":"10.1134/S1070363225600882","DOIUrl":"10.1134/S1070363225600882","url":null,"abstract":"<p>Phenylethylamine (PEA) derivatives are integral to pharmaceutical and material synthesis. The introduction of fluorinated functional groups can induce modifications in the molecular properties. Consequently, it is essential to examine the effects of fluorinated functional groups on the various properties of PEA derivatives. This analysis revealed the specific impact of fluorinated substitution on the various properties of PEA and three fluorine-substituted derivatives, namely PEA–F (<i>para</i>-fluorophenylethylamine), PEA–CF<sub>3</sub> (<i>para</i>-trifluoromethylphenyl ethylamine), and PEA–4F–CF<sub>3</sub> (4-trifluoromethyl-2,3,5,6-tetrafluorophenyl ethylamine). Specifically, as the molecular structure varied, corresponding changes were observed in molecular polarity, energy gap, surface electrostatic potentials, and spectral characteristic peaks. These variations are vital for understanding and predicting the potential applications of fluorinated phenethylamine derivatives.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1104 - 1116"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. A. Pakholka, A. V. Churakov, S. G. Krivokolisko
{"title":"Synthesis of 6-Amino-4-aryl-5-(4-arylthiazol-2-yl)-2-ethoxynicotinonitriles","authors":"N. A. Pakholka, A. V. Churakov, S. G. Krivokolisko","doi":"10.1134/S1070363225601024","DOIUrl":"10.1134/S1070363225601024","url":null,"abstract":"<p>Reactions of 2-(4-arylthiazole-2-yl)acetonitriles with 4-methoxybenzylidenemalononitrile and potassium hydroxide or (2<i>E</i>)-3-aryl-2-(4-arylthiazole-2-yl)acrylonitriles with malonitrile and sodium ethylate in ethanol proceeded to form 6-amino-4-aryl-5-(4-arylthiazole-2-yl)-2-ethoxynicotinonitriles with yields of 32–65%. Treatment of 6-amino-2-ethoxy-4-(4-methoxyphenyl)-5-[4-(4-methoxyphenyl)thiazole-2-yl]nicotinonitrile with an excess of molecular bromine produced 6-amino-5-[5-bromo-4-(4-methoxyphenyl)thiazole-2-yl]-2-ethoxy-4-(4-methoxyphenyl)nicotinonitrile with a yield of 45%.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1133 - 1140"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S1070363225601024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of Functional Materials from Basic Bismuth(III) Nitrates","authors":"E. V. Timakova, T. E. Timakova, L. I. Afonina","doi":"10.1134/S1070363225601036","DOIUrl":"10.1134/S1070363225601036","url":null,"abstract":"<p>Main synthetic routes to bismuth-containing functional materials from basic bismuth nitrates with the compositions [Bi<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub>](NO<sub>3</sub>)<sub>6</sub>·H<sub>2</sub>O and [Bi<sub>6</sub>O<sub>5</sub>(OH)<sub>3</sub>](NO<sub>3</sub>)<sub>5</sub>·3H<sub>2</sub>О, which are high-purity products of hydrolytic processing of technological solutions with respect to the content of metal impurities relative to bismuth, are considered. Basic bismuth oxalate and bismuth(III) oxide salicylate with the compositions BiOH(C<sub>2</sub>O<sub>4</sub>) and BiO(C<sub>7</sub>H<sub>5</sub>O<sub>3</sub>), respectively, were obtained by treatment of basic bismuth nitrates with solutions of the corresponding carboxylic acids. The compositions of the compounds were identified by X-ray phase and chemical analyses, IR and Raman spectroscopy, and thermogravimetry. The conditions for oxidative thermolysis of BiO(C<sub>7</sub>H<sub>5</sub>O<sub>3</sub>) to obtain the tetragonal modification of bismuth oxide β-Bi<sub>2</sub>O<sub>3</sub> have been determined. The processes of thermolysis of the synthesized bismuth carboxylates in an inert atmosphere and in vacuum to obtain Bi–C composites have been considered.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1141 - 1152"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. A. Pakholka, V. V. Dotsenko, A. V. Churakov, and S. G. Krivokolysko
{"title":"Synthesis, Structure, and Bromination of 3-(Arylamino)-2-(4-arylthiazol-2-yl)acrylonitriles","authors":"N. A. Pakholka, V. V. Dotsenko, A. V. Churakov, and S. G. Krivokolysko","doi":"10.1134/S1070363225601498","DOIUrl":"10.1134/S1070363225601498","url":null,"abstract":"<p>A series of previously undescribed 3-(arylamino)-2-(4-arylthiazol-2-yl)acrylonitriles were prepared by the Hantzsch reaction between 3-(arylamino)-2-cyanothioacrylamides and α-bromoketones. Bromination of the prepared 3-(arylamino)-2-(4-arylthiazol-2-yl)acrylonitriles proceeded regioselectively at the C<sup>5</sup> position of, thiazole ring to form previously unknown 3-(arylamino)-2-(4-aryl-5-bromothiazol-2-yl)acrylonitriles in 42–85% yields. Structures of the new compounds were confirmed by 2D NMR (<sup>1</sup>H–<sup>13</sup>C, <sup>1</sup>H–<sup>15</sup>N HSQC, <sup>1</sup>H–<sup>13</sup>C, <sup>1</sup>H–<sup>15</sup>N HMBC) and single crystal X-ray diffraction analysis.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1210 - 1224"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. R. Safargalin, L. A. Dachaeva, A. A. Mukhamedzyanova, R. R. Gataullin
{"title":"Synthesis of Substituted 1,3-Benzoxazines and Their Anticorrosion Activity","authors":"R. R. Safargalin, L. A. Dachaeva, A. A. Mukhamedzyanova, R. R. Gataullin","doi":"10.1134/S1070363225601334","DOIUrl":"10.1134/S1070363225601334","url":null,"abstract":"<p>The reactions of phenol (or <i>ortho</i>-allylphenol) with paraformaldehyde and substituted anilines (or allylamine) yielded 3-allyl-, 3-aryl- or 8-allyl-3-aryl-1,3-benzoxazines. A study of the corrosion inhibitory activity of the synthesized compounds revealed that the degree of protection (<i>Z</i>) in the case of 8-allyl homologues in a 15% HCl solution reaches 96–98%. The absence of an allyl substituent at the C<sup>8</sup> carbon atom of the benzoxazine core leads to a decrease in protection to 75–76%.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1199 - 1203"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. T. Mascarenhas, J. B. Wable, H. N. Akolkar, P. J. Prabhu
{"title":"Synthesis and Antimicrobial Evaluation of (E)-1-(2,4-Dichlorophenyl)-4-{3-methoxy-4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]benzylidene}-3-methyl-1H-pyrazol-5(4H)-one Derivatives","authors":"C. T. Mascarenhas, J. B. Wable, H. N. Akolkar, P. J. Prabhu","doi":"10.1134/S1070363225600237","DOIUrl":"10.1134/S1070363225600237","url":null,"abstract":"<p>A series of novel pyrazolone-triazole compounds based on (<i>E</i>)-1-(2,4-dichlorophenyl)-4-[3-methoxy-4-(prop-2-yn-1-yloxy)benzylidene]-3-methyl-1<i>H</i>-pyrazol-5(4<i>H</i>)-one was synthesized the click chemistry methodology. Antibacterial and antifungal properties of the new compounds were tested. While seven compounds demonstrated antimicrobial activity against a range of bacterial strains, including <i>Escherichia coli</i>, <i>Staphylococcus aureus, Pseudomonas aeruginosa</i> and <i>Streptococcus pyogenes</i> it was comparable to the drug ampicillin whereas one compound exhibited excellent antifungal activity in terms of its standard drug griseofulvin against <i>Candida albicans</i>. Rest of the compounds showed good antifungal activity against <i>Candida albicans</i> when compared to griseofulvin. The newly synthesized 1,2,3-triazoles showed good antibacterial activity and can be used as precursors of drug molecules in the future.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1057 - 1067"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. E. Zhuravlev, A. D. Kaftanov, L. I. Voronchikhina
{"title":"Synthesis, Thermal Stability, and Colloid-Chemical Properties of Pyridinium Ionic Liquids with the Bromotrichloroferrate Anion","authors":"O. E. Zhuravlev, A. D. Kaftanov, L. I. Voronchikhina","doi":"10.1134/S1070363225601309","DOIUrl":"10.1134/S1070363225601309","url":null,"abstract":"<p>Ionic liquids were synthesized: 1-alkylpyridinium bromotrichloroferrates(III) [C<sub>5</sub>H<sub>5</sub>N–R]FeCl<sub>3</sub>Br, where R = H, C<sub>2</sub>H<sub>5</sub>, C<sub>4</sub>H<sub>9</sub>, C<sub>6</sub>H<sub>13</sub>, C<sub>8</sub>H<sub>17</sub>, C<sub>10</sub>H<sub>21</sub>, C<sub>12</sub>H<sub>25</sub>, or C<sub>16</sub>H<sub>33</sub>. All compounds were characterized by IR and visible spectroscopy data. Their thermal stability in air was studied in the temperature range of 25–600°C, as well as the thermal stability of 1-alkylpyridinium bromides. The influence of the alkyl chain length in the cation and the nature of the anion on the thermal stability of ionic liquids was established. A comparative analysis of the thermal stability of 1-alkylpyridinium bromides and bromotrichloroferrates was carried out. For ionic liquids with long-chain radicals, the critical micelle concentration was determined by conductometry. Surface tension isotherms were obtained and the main colloid-chemical properties were calculated.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1182 - 1191"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. E. Lapuk, I. O. Nasibullin, L. S. Zubaidullina, R. A. Larionov, V. A. Burilov, Kh. R. Khayarov, R. N. Nagrimanov, A. V. Gerasimov
{"title":"Kinetic Stability of Amorphous Glasses of New Sulfonamide-Based Prodrugs According to Differential Scanning Calorimetry Data","authors":"S. E. Lapuk, I. O. Nasibullin, L. S. Zubaidullina, R. A. Larionov, V. A. Burilov, Kh. R. Khayarov, R. N. Nagrimanov, A. V. Gerasimov","doi":"10.1134/S1070363225601929","DOIUrl":"10.1134/S1070363225601929","url":null,"abstract":"<p>The production of prodrugs aimed at enhancing various properties of pharmaceuticals is a remains one of the most relevant and dynamic fields in modern pharmaceutical chemistry. While attaching a hydrophobic fragment can enhance cell wall permeability in drug design, it often comes at the cost of reduced solubility and bioavailability. One effective strategy to address this issue is to convert the drug into an amorphous form. However, the practical application of amorphous forms is hindered by the complexities involved in their preparation and their low kinetic and thermodynamic stability. In this study, we synthesized prodrugs based on sulfapyridine and sulfamethizole. We propose methods for producing an amorphous state and assess its stability using both non-isothermal and isothermal kinetics approaches. Our findings indicate that the amorphous forms of studied compounds are stable at room temperature for over 10 years. The results of the study can be used in the development of approaches to obtaining stable amorphous forms of drugs.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1225 - 1235"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Jadhav, I. Jamadar, R. G. Kalkhambkar, M. S. Refat, A. Mohammed Alsuhaibani
{"title":"Cu(OAc)2 Catalyzed, Microwave Assisted O-Arylation of Phenols with Haloarenes Using Guanidinium Ionic Liquids as Recyclable System Under Mild Reaction Conditions","authors":"V. Jadhav, I. Jamadar, R. G. Kalkhambkar, M. S. Refat, A. Mohammed Alsuhaibani","doi":"10.1134/S1070363224612791","DOIUrl":"10.1134/S1070363224612791","url":null,"abstract":"<p>Microwaves assisted straightforward and eco-friendly <i>O</i>-arylation of phenols with different substituted haloarenes has been demonstrated using Cu catalyst in guanidinium ionic liquid (GIL). The generation of the C–O bond via metal catalyst in GIL is demonstrated using green chemistry approach. This method provides an effective way to synthesize various biaryl ethers under mild reaction conditions. The effective recyclability and reusability of GIL up to five cycles have been performed very successfully which is the additional advantages of this method.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1037 - 1047"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}