Anastasia S. Skrylkova, Dmitry M. Egorov, Dar’ya V. Spiridonova
{"title":"Synthesis of 3,4,5,6,7,8-Hexahydro-4-aryl-8-arylidene-2(1H)-quinazolinethiones and Their Reactions with Dialkyl Chloroethynylphosphonates","authors":"Anastasia S. Skrylkova, Dmitry M. Egorov, Dar’ya V. Spiridonova","doi":"10.1134/S1070363225607549","DOIUrl":"10.1134/S1070363225607549","url":null,"abstract":"<p>A series of 3,4,5,6,7,8-hexahydro-4-aryl-8-arylidene-2(1<i>H</i>)-quinazolinethiones was obtained by the reaction of cyclohexanone bis-chalcones with thiourea. Further modification using chloroethynylphosphonate afforded a series of new phosphorylated thiazolo[2,3-<i>b</i>]quinazoline derivatives.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Galina R. Mingaleeva, Safiya M. Mulyukova, Il’ya N. Korolev, Vadim Z. Mingaleev
{"title":"Kinetics of Swelling of Covalent and Covalent-Ionic Chitosan-Based Hydrogels: Models Comparison","authors":"Galina R. Mingaleeva, Safiya M. Mulyukova, Il’ya N. Korolev, Vadim Z. Mingaleev","doi":"10.1134/S1070363225607719","DOIUrl":"10.1134/S1070363225607719","url":null,"abstract":"<p>In this work, chitosan hydrogels crosslinked by covalent-ionic and covalent bonds were obtained, and the kinetic features of their swelling in physiological saline were studied. It was found that the first-order kinetic model is the least suitable for approximating the experimental data. While the second-order model and especially the mixed swelling model best describe the experimental data. Analysis of the kinetic parameters of equilibrium swelling showed that covalent-ionic chitosan hydrogels are characterized by a high content of swelling sites and a low rate of relaxation of polymer chains in these sites. Covalent chitosan hydrogels exhibit the opposite pattern: the content of swelling sites is lower, but the relaxation rate of their chains is higher. At the same time, the contribution of water diffusion to the swelling sites increases with decreasing cross-linker concentration, and this contribution for covalent-ionic hydrogels is higher than for covalent hydrogels.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of Bases of Different Nature in the Cross-Coupling Reaction of p-Xylene and p-Iodonitrobenzene","authors":"Tatyana V. Bezbozhnaya","doi":"10.1134/S1070363225608129","DOIUrl":"10.1134/S1070363225608129","url":null,"abstract":"<p>The influence of organic and inorganic bases and their mixtures on the yield of 2,5-dimethyl-4′-nitrobiphenyl in the cross-coupling reaction of <i>p</i>-xylene and <i>p</i>-iodonitrobenzene catalyzed by a phenanthroline platinum(II) complex has been studied. It has been shown that the most effective base is a 50% aqueous solution of KOH, which is explained by the high thermodynamic activity of the hydroxide ion and the low thermodynamic activity of water in this system.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Pyrimidine Derivatives Incorporating a Semicarbazide Moiety as Potential Antioxidant Inhibitors: Synthesis, Antioxidant Activity, Molecular Docking, ADMET, and Drug-likeness Studies","authors":"Can He, Lu Yu, Pei Li","doi":"10.1134/S1070363225607707","DOIUrl":"10.1134/S1070363225607707","url":null,"abstract":"<p>In this study, a series of novel pyrimidine derivatives incorporating a semicarbazide moiety were synthesized, and their structures were comprehensively characterized by means of <sup>1</sup>H, <sup>13</sup>C NMR, and HRMS. Biological evaluation revealed that compound <i>N</i>-benzyl-2-(4,6-dimethylpyrimidin-2-yl)hydrazine-1-carboxamide exhibited significant <i>in vitro</i> DPPH and ABTS radical scavenging activities, with IC<sub>50</sub> values of 4.9 and 3.8 μg/mL, respectively, lower than those of the reference antioxidants vitamin C (6.4 μg/mL) and Trolox (8.4 μg/mL). Meanwhile, molecular docking analysis further demonstrated that compound <i>N</i>-benzyl-2-(4,6-dimethylpyrimidin-2-yl)hydrazine-1-carboxamide engages in multiple intermolecular interactions within the active site of NADPH oxidase (PDB ID: 2CDU), including van der Waals forces, conventional hydrogen bonds, π-sulfur, alkyl, and π-alkyl interactions. Furthermore, ADMET profiling and drug-likeness assessments indicated that <i>N</i>-benzyl-2-(4,6-dimethylpyrimidin-2-yl)hydrazine-1-carboxamide possesses favorable physicochemical properties and an acceptable safety profile, consistent with the characteristics of promising drug candidates. To the best of our knowledge, this work constitutes the first systematic investigation of pyrimidine derivatives bearing a semicarbazide scaffold.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characterization of Imidazo[1,2-b]pyridazine Derivative: Synthesis, Crystal Structure, DFT, Hirshfeld Surface and Antitumor Activity","authors":"Zhonghui Tian, Tingting Yuan, Hongyu Dai, Zhixu Zhou, Zhuyan Huang, Chunshen Zhao, Zhaopeng Zheng","doi":"10.1134/S1070363225607872","DOIUrl":"10.1134/S1070363225607872","url":null,"abstract":"<p>Imidazo[1,2-<i>b</i>]pyridazine derivatives have demonstrated diverse pharmacological activities in multiple scientific research fields, especially showing broad application prospects in medicinal chemistry. In this study, the target <i>N</i>-(2,5-dimethylphenyl)-6-(methanesulfonylamino)imidazo[1,2-<i>b</i>]pyridazine-2-carboxamide was successfully prepared through a five-step synthetic route. To comprehensively confirm its molecular structure, various analytical techniques, including <sup>1</sup>H, <sup>13</sup>C NMR, infrared spectroscopy, and high-resolution mass spectrometry, were employed for characterization. Additionally, a single crystal of the compound and its crystal structure were precisely determined using single-crystal X-ray diffraction. Moreover, density functional theory was utilized to theoretically simulate the molecular structure, and the experimentally obtained structure was compared with the theoretically predicted conformation. The vibrational properties, Hirshfeld surface molecular docking, and antitumor activity of the compound were also analyzed. The study further explored the spatial distribution characteristics of the frontier molecular orbitals and molecular electrostatic potential, thereby evaluating their influence on the chemical properties of the compound. This provides important theoretical support for understanding the reaction characteristics and potential mechanisms of action of the compound.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sagar S. Patil, Yogita A. Patil, Prakash K. Labhane
{"title":"Fabrication of a Functionalized Bimetallic MOF on MOF Embedded Graphene Oxide for the Removal of Contaminants from Wastewater","authors":"Sagar S. Patil, Yogita A. Patil, Prakash K. Labhane","doi":"10.1134/S1070363225607409","DOIUrl":"10.1134/S1070363225607409","url":null,"abstract":"<p>An effective approach to remove contaminants from water is essential for maintaining water safety. Adsorption is an efficient technique for contaminants removal due to its cost effectiveness, energy efficiency, simplicity, and environmental acceptability. This study presents the development of a mixed metal MOF on MOF embedded graphene oxide (MMOFs/GO), with the goal of the sustainable adsorptive elimination of contaminants from water. The MMOFs/GO have enhanced adsorption capability and stability for the removal of dyes, mixed dyes, and antibiotics from water. MMOFs/GO exhibits a substantial surface area of 1060 m<sup>2</sup>/g, accompanied by a total pore volume of 0.30 cm<sup>3</sup>/g. The prolonged surface area offered by GO and the “blocks” within the composite is one of the factors that enhance the adsorption efficacy of MMOFs/GO. Furthermore, MMOFs/GO has demonstrated significant effectiveness when employed for the remediation of washing effluent. The hybrid of mixed-metal MOFs incorporated with GO serves as a sustainable path for the treatment of real wastewater.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalya V. Zakharova, Galina K. Lebedeva, Taras Yu. Zakharov, Svetlana V. Kononova
{"title":"Determination of the Mark–Kuhn–Houwink–Sakurada Equation Constants for Solutions of Hydroxyl-Containing Poly(amide imide)s in N-Methylpyrrolidone","authors":"Natalya V. Zakharova, Galina K. Lebedeva, Taras Yu. Zakharov, Svetlana V. Kononova","doi":"10.1134/S1070363225606970","DOIUrl":"10.1134/S1070363225606970","url":null,"abstract":"<p>Hydroxyl-containing poly(amide imide)s (PAI-OH) in the molecular weight range from 44 to 146 kDa were studied by molecular hydrodynamics (viscometry) and light scattering in dilute solutions in N-methylpyrrolidone (N-MP). Scaling Mark–Kuhn–Houwink relationships were established, which made it possible to determine the key conformational parameters of the macromolecules. It was shown that in the studied molecular weight range, the PAI-OH macromolecule in N-MP should be considered as a relatively semi-rigid chain. The Kuhn segment length was determined to be 25±1 Å. Based on the obtained data, a calibration equation was derived that allows rapid estimation of the molecular weight of membrane-forming PAI-OH samples (<i>M</i><sub>w</sub> > 40 kDa) from viscometry data. The results of this work are important for predicting the properties of polymer materials and membranes based on hydroxyl-containing poly(amide imide)s.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polysaccharides as Modulators of Bovine Serum Albumin Fibril Formation","authors":"Alena A. Nikiforova, Igor A. Sedov, Yuriy F. Zuev","doi":"10.1134/S1070363225606635","DOIUrl":"10.1134/S1070363225606635","url":null,"abstract":"<p>In this study, the effect of various polysaccharides including dextran, hyaluronic acid, κ-, ι-, and λ-carrageenans, on the kinetics of bovine serum albumin (BSA) fibrillation at 65°C was investigated using thioflavin T (ThT) assay. It was found that these polysaccharides modulate the fibrillation process differently: dextran weakly promotes fibrillation, hyaluronic acid shows almost no impact, while carrageenans demonstrate the most pronounced effects, which depends on polysaccharide concentration. The addition of sodium chloride was shown to affect the protein-polysaccharide interactions primarily by weakening the electrostatic contribution and stabilizing the native protein form. The results expand our understanding on protein aggregation processes in the presence of polysaccharides and may be useful for developing the methods to design biopolymer complexes with tailorable properties.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anastasia S. Skrylkova, Dmitry M. Egorov, Aleksandr S. Krylov, Ekaterina N. Chernova
{"title":"Synthesis and Phosphonylation of 2-Hydrazinyl-5,6-disubstituted Pyrimidin-4(3H)-ones","authors":"Anastasia S. Skrylkova, Dmitry M. Egorov, Aleksandr S. Krylov, Ekaterina N. Chernova","doi":"10.1134/S1070363225607227","DOIUrl":"10.1134/S1070363225607227","url":null,"abstract":"<p>A series of 2-hydrazinylpyrimidin-4-ones was obtained by the reaction of hydrazine hydrate with <i>S</i>-methyl-2-thiouracil derivatives. The resulting compounds were reacted with chloroethynylphosphonates resulting in new phosphonylated dihydroformazans containing pyrimidin-2-yl-4-one fragments.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yufang Wang, Xi Luo, Tianyu Zhao, Yikun Wang, Liya Wang
{"title":"Crystal Structure and Magnetic Properties A Nickel(II) Complex with 3-Hydroxyisonicotinic Acid Ligand","authors":"Yufang Wang, Xi Luo, Tianyu Zhao, Yikun Wang, Liya Wang","doi":"10.1134/S1070363225607458","DOIUrl":"10.1134/S1070363225607458","url":null,"abstract":"<p>A new nickel(II) coordination polymer [Ni<sub>2</sub>(L)<sub>2</sub>(bpa)<sub>2</sub>(H<sub>2</sub>O)]<sub><i>n</i></sub>·3<i>n</i>(H<sub>2</sub>O) was solvothermally synthesized with nickel sulfate, 3-hydroxyisonicotinic acid (H<sub>2</sub>L) and 1,2-bi(4-pyridyl)ethane (bpa). The complicated space structure was confirmed by single-crystal X-ray diffraction analysis. The crystal belongs to the triclinic space group <i>P</i>-1. The L<sup>2–</sup> ligand bridges the Ni(II) to form a 2D layer, which is connected through bpa ligands to form a 3D framework structure. The thermal properties of the complex were investigated. The magnetic susceptibility data of the complex indicate that dominant antiferromagnetic interactions are mediated between Ni(II) centers.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}