6-氨基-4-芳基-5-（4-芳基噻唑-2-基）-2-乙氧基烟碱腈的合成

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI:10.1134/S1070363225601024

N. A. Pakholka, A. V. Churakov, S. G. Krivokolisko

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引用次数: 0

摘要

2-（4-芳基噻唑-2-基）乙腈与4-甲氧基苄基甲腈和氢氧化钾反应，或(2E)-3-芳基-2-（4-芳基噻唑-2-基）丙烯腈与丙腈和乙醇中的乙磺酸钠反应，生成6-氨基-4-芳基-5-（4-芳基噻唑-2-基）-2-乙氧基烟腈，产率为32-65%。用过量的分子溴处理6-氨基-2-乙氧基-4-（4-甲氧基苯基）-5-[4-（4-甲氧基苯基）噻唑-2-基]- 6-氨基-5-[5-溴-4-（4-甲氧基苯基）噻唑-2-基]-2-乙氧基-4-（4-甲氧基苯基）烟腈，产率为45%。

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Synthesis of 6-Amino-4-aryl-5-(4-arylthiazol-2-yl)-2-ethoxynicotinonitriles

Reactions of 2-(4-arylthiazole-2-yl)acetonitriles with 4-methoxybenzylidenemalononitrile and potassium hydroxide or (2E)-3-aryl-2-(4-arylthiazole-2-yl)acrylonitriles with malonitrile and sodium ethylate in ethanol proceeded to form 6-amino-4-aryl-5-(4-arylthiazole-2-yl)-2-ethoxynicotinonitriles with yields of 32–65%. Treatment of 6-amino-2-ethoxy-4-(4-methoxyphenyl)-5-[4-(4-methoxyphenyl)thiazole-2-yl]nicotinonitrile with an excess of molecular bromine produced 6-amino-5-[5-bromo-4-(4-methoxyphenyl)thiazole-2-yl]-2-ethoxy-4-(4-methoxyphenyl)nicotinonitrile with a yield of 45%.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.