Russian Journal of General Chemistry最新文献_第10页

Interaction of C-Alkylsubstituted-1,5,10,14-tetraazacyclooctadeca-4,13-diene with Carboxylic Acid Halides As a New Method for the Synthesis of C- and N-Acyl-2,3,6,7,8,9-hexahydro-1H-1,5-diazonines C-烷基取代的-1,5,10,14-四氮杂环十八碳-4,13-二烯与羧酸卤化物的相互作用是合成 C-和 N-酰基-2,3,6,7,8,9-六氢-1H-1,5-二氮杂蒽的新方法

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-29 DOI: 10.1134/S1070363224090044

N. A. Anisimova, V. V. Mikhailov

引用次数: 0

Computational Investigation with Toxicophore Study of 1,2,3-Triazole Derivatives as an Effective Inhibitor Against Prostate Cancer 将 1,2,3-三唑衍生物作为前列腺癌有效抑制剂的计算研究与毒物研究

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-29 DOI: 10.1134/S1070363224090238

Y. Koubi, Y. Moukhliss, O. Abdessadak, M. Alaqarbeh, M. A. Ajanaa, H. Maghat, T. Lakhlifi, M. Bouachrine

{"title":"Computational Investigation with Toxicophore Study of 1,2,3-Triazole Derivatives as an Effective Inhibitor Against Prostate Cancer","authors":"Y. Koubi, Y. Moukhliss, O. Abdessadak, M. Alaqarbeh, M. A. Ajanaa, H. Maghat, T. Lakhlifi, M. Bouachrine","doi":"10.1134/S1070363224090238","DOIUrl":"10.1134/S1070363224090238","url":null,"abstract":"Prostate cancer is a well-known disease that has gained significant attention in recent years. To improve and suggest new compounds with anticancer activity, it has become essential to identify new proposed agents through innovative and reliable methods such as computational small molecule discovery methods. In this regard, 3D-QSAR and Molecular Docking studies have been conducted on disubstituted 1,2,3-triazole derivatives as antiproliferative analogs, using static methods to find the right model. The study established 3D-QSAR model based on Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Index Analysis (CoMSIA). The best model was obtained with CoMFA model (Q2 = 0.696, R2 = 0.992, R = 0.985) and CoMSIA model (Q2 = 0.582, R2 = 0.992, R = 0.984) statistical coefficients. To determine the predictive power of the model, we need to calculate the parameters of k, Roy, Golbraikh, and Tropsha for the test set and the y, SEE, and t-F randomization tests for the training set. Docking’s results suggest that amino acids (PDB; 3 ERT), Asp351, Leu384, Arg394, Phe404, Leu346, Leu525, and Thr347, have a significant interest in anticancer activity. The CoMFA model’s steric and electrostatic field contours were studied to determine the results further. The study suggests four new antiproliferative agents that have demonstrated reliability through ADMET and toxicophore methods.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2445 - 2459"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Synthesis of Zinc Oxide Nanoparticles: Anticancer аnd Antibacterial Applications (A Review) 氧化锌纳米粒子的绿色合成：抗癌和抗菌应用（综述）

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-29 DOI: 10.1134/S1070363224090500

S. López-Cuenca, R. Salazar-Peña, M. A. Pedroza-Toscano

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Metal Exchange Reaction of Mg(II)-Octa-(4-fluorophenyl)tetraazaporphyrin with d-Metal Salts in Dimethylformamide 二甲基甲酰胺中八-(4-氟苯基)四氮杂卟啉镁(II)与 d-金属盐的金属交换反应

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-29 DOI: 10.1134/S1070363224090093

S. V. Zvezdina, N. V. Chizhova, N. Zh. Mamardashvili

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An Eco-Friendly Ultrasound-Assisted Synthesis of a New Poly(thiourea-amide) and Its Application in the Removal of Ni(II) Ions from an Aqueous Solution 一种新型聚（硫脲酰胺）的环保型超声辅助合成及其在去除水溶液中的镍（II）离子中的应用

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-29 DOI: 10.1134/S1070363224090184

W. A. Radhi, T. E. Jasim, A. M. Jassem

{"title":"An Eco-Friendly Ultrasound-Assisted Synthesis of a New Poly(thiourea-amide) and Its Application in the Removal of Ni(II) Ions from an Aqueous Solution","authors":"W. A. Radhi, T. E. Jasim, A. M. Jassem","doi":"10.1134/S1070363224090184","DOIUrl":"10.1134/S1070363224090184","url":null,"abstract":"An ultrasound-assisted synthesis of a new polymer, poly[N1-({4-[3-(4-aminophenoxy)phenoxy]phenyl}carbamothioyl)-N3-thioformylisophthalamide] by a polycondensation reaction of isophthaloyl diisothiocyanate and 4,4′-(1,3-phenylenedioxy)dianiline was reported. Different techniques were utilized to prove the chemical structure of the synthesized polymer, including FTIR, 1H NMR, TGA, Brunauer–Emmett–Teller (BET), and field emission scanning electron microscopy (FESEM). The capability of the synthesized polymer to adsorb Ni(II) ions from an aqueous solution was analytically evaluated. The change of several parameters including contact time, Ni(II) ions concentration, pH, and temperature on the adsorption process onto the target polymer was extensively investigated. The results indicated that the optimal adsorption pH was about 7 with the removal efficiency of 78.379% and the adsorbed amount of Ni(II) ions increased when the temperature was increased. The adsorption isotherms analysis revealed that the Langmuir model was the most relevant to describe the adsorption process compared with the Freundlich model. The study of adsorption kinetics showed that the adsorption model of Ni(II) ions onto the surface polymer being significantly correlated with pseudo-second-order model. Based on the thermodynamic studies, the calculated ΔG was negative, ΔH was endothermic, and ΔS was positive, verifying that the adsorption process is spontaneous.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 9","pages":"2382 - 2391"},"PeriodicalIF":0.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142540667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disulfonamide Piperazine Derivatives: Synthesis, Characterization, Crystal Structures Studies, and Evaluation of Cell Proliferation Activity 二磺酰胺哌嗪衍生物：合成、表征、晶体结构研究和细胞增殖活性评估

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-04 DOI: 10.1134/S1070363224080267

L. Beliyaiah, A. Dilkalal, Vinaya, U. Basavaiah, S. Parkin, R. J. Butcher, H. S. Yathirajan, Y. B. Basavaraju

{"title":"Disulfonamide Piperazine Derivatives: Synthesis, Characterization, Crystal Structures Studies, and Evaluation of Cell Proliferation Activity","authors":"L. Beliyaiah, A. Dilkalal,  Vinaya, U. Basavaiah, S. Parkin, R. J. Butcher, H. S. Yathirajan, Y. B. Basavaraju","doi":"10.1134/S1070363224080267","DOIUrl":"10.1134/S1070363224080267","url":null,"abstract":"In the present study, disulfonamides piperazine derivatives were synthesized by Hinsberg reaction of various sulfonyl chlorides with 2-(piperazin-1-yl)ethanamine and evaluation their cell proliferation activity. All the synthesized compounds were characterized by 1H, 13C NMR, mass spectrometry and X-ray crystallographic techniques. X-ray diffraction studies revealed that the central piperazine ring and two terminal substituted sulfonyl phenyl rings joined by sulfonamide linkage are present in every structure. The cell proliferation activity of synthesized compounds was measured on human buccal mucosa oral fibroblast primary cell lines. Among the synthesized compounds, 4-nitro-N-(2-{4-[(4-nitrophenyl)sulfonyl]piperazin-1-yl}ethyl)benzenesulfonamide, 4-(trifluoromethyl)-N-[2-(4-[4-(trifluoromethyl)phenyl]sulfonyl}piperazin-1-yl)ethyl]benzenesulfonamide and 2-nitro-N-(2-{4-[(2-nitrophenyl)sulfonyl]piperazin-1-yl}ethyl)benzenesulfonamide showed potential activity against tested cell lines.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 8","pages":"2167 - 2179"},"PeriodicalIF":0.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142409930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Synthesis of Ethyl 2-[(1H-Indol-3-yl)(phenyl)methyl]-3-oxobutanoate Derivatives Using NiO Nanocatalysts 使用氧化镍纳米催化剂绿色合成 2-[(1H-吲哚-3-基)(苯基)甲基]-3-氧代丁酸乙酯衍生物

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-04 DOI: 10.1134/S1070363224080164

Pratibha, R. Das, G. Serdaroğlu, J. Pandit, A. K. Bahe, A. K. Mishra

引用次数: 0

Synthesis, Characterization, and Thermal Properties of Liquid Iron Amidinates and Their Potential as Chemical Vapor Deposition Precursors for Producing Iron-Containing Films 液态酰胺铁的合成、表征和热性能及其作为化学气相沉积前驱体生产含铁薄膜的潜力

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-04 DOI: 10.1134/S1070363224080218

Y. Zhang, C. Yao, L. Liu, Y. Sun, Y. Fu, H. Wang, L. Du

{"title":"Synthesis, Characterization, and Thermal Properties of Liquid Iron Amidinates and Their Potential as Chemical Vapor Deposition Precursors for Producing Iron-Containing Films","authors":"Y. Zhang, C. Yao, L. Liu, Y. Sun, Y. Fu, H. Wang, L. Du","doi":"10.1134/S1070363224080218","DOIUrl":"10.1134/S1070363224080218","url":null,"abstract":"Chemical vapor deposition (CVD) has become a favorable method for preparation of iron-containing films. However, as a key role in the CVD process, the available liquid iron precursor is scarce. To this aim, this study synthesized two liquid iron complexes using sec-butyl-containing amidines as ligands, and the synthesized complexes’ structures were characterized through 1H NMR spectroscopy and elemental analysis. Thermogravimetric analysis (TGA) was employed to study the thermal properties (including volatility, thermal stability, and vapor pressure) of the designed complexes, and the results demonstrated that both complexes have excellent volatility, sufficient thermal stability and vapor pressure. The reactivity of the complexes was observed through solution reactions between them and conventional co-reagents, and both complexes exhibited high reactivity. Moreover, the applicability of the synthesized complexes as CVD precursors were evaluated through film deposition experiment, and a continuous, uniform, high purity, and smooth α-Fe2O3 film was obtained. These results demonstrated that the synthesized complexes are promising precursors for the CVD of iron-containing films.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 8","pages":"2080 - 2087"},"PeriodicalIF":0.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142409911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Biological Activity of 2,6-Substituted Pyridoxine Derivatives. Unusual Catalytic Role of Selenium Dioxide in the Formation of Pyridinone Methides 2,6-取代吡哆醇衍生物的合成与生物活性。二氧化硒在形成吡啶酮甲苷过程中的非同寻常的催化作用

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-04 DOI: 10.1134/S1070363224080036

R. M. Khaziev, E. A. Platonova, O. V. Bondar, A. S. Khristolyubova, N. Y. Serov, S. A. Lisovskaya, R. M. Vafina, V. G. Shtyrlin, N. V. Shtyrlin, D. R. Islamov, V. A. Burilov, E. I. Romanova, Yu. G. Shtyrlin

引用次数: 0

Synthesis, In Silico Studies, Antimicrobial, Antioxidant Activities, Docking Simulation, and Computational Analysis of Novel Acrylamide Derivatives 新型丙烯酰胺衍生物的合成、硅学研究、抗菌和抗氧化活性、对接模拟和计算分析

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2024-10-04 DOI: 10.1134/S1070363224080188

H. Bayrak, A. M. Fahim, G. M. Boyraci, F. Y. Karahalil

{"title":"Synthesis, In Silico Studies, Antimicrobial, Antioxidant Activities, Docking Simulation, and Computational Analysis of Novel Acrylamide Derivatives","authors":"H. Bayrak, A. M. Fahim, G. M. Boyraci, F. Y. Karahalil","doi":"10.1134/S1070363224080188","DOIUrl":"10.1134/S1070363224080188","url":null,"abstract":"New acrylamide compounds based on 4-aminoantipyrine were synthesized. 4-Acetaminoantipyrine was synthesized and its reactivity with salicylic aldehyde, vanillin, isovanillin and 5-methoxysalicylaldehyde with the formation of new N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-(aryl)acrylamides was investigated. In addition, synthesized acrylamides were screened for ADME studies to elucidate their properties. The antimicrobial and antioxidant activitiy of the newly synthesized compounds were exceptionally high, surpassing the performance of the reference standard drug. Molecular docking simulations further confirmed these results, highlighting the heightened activity attributed to the substitute groups on the aromatic rings with different proteins and showed different interactions, confirming their biological evaluation. The optimization of target compounds using the DFT/B3LYP/6-311G(d) basis set demonstrated their stability and provided insights into their physical descriptors—Electrostatic Potential (ESP) and Molecular Electrostatic Potential (MEP). The analysis revealed both electrophilic and nucleophilic characters, showcasing their versatile binding capabilities in various pockets and confirming the biological results.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 8","pages":"2044 - 2060"},"PeriodicalIF":0.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142409950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0