含环丁烷、环戊烷或环己烷片段的N，N ' -（乙烷-1,2-二基）二（spiroazetitin -2ones）的合成及镇痛活性

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-08-05 DOI:10.1134/S107036322560211X

E. A. Nikiforova, L. A. Vasilenko, R. R. Makhmudov, D. P. Zverev, M. V. Dmitriev, D. V. Baibarodskikh, N. F. Kirillov

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引用次数: 0

摘要

研究发现，由甲基-1-溴环丁烷-、1-溴环戊烷-和1-溴环己anecarboxylates和锌合成的Reformatsky试剂与由乙二胺和芳香醛衍生的二亚胺以2:1的摩尔比反应生成相应的双（spiroazetitin -2-ones）。所得化合物的结构经单晶x射线衍射分析证实。对合成化合物的体内镇痛活性进行了评估，并显示出明显的效果，超过了参比药物（甲硝唑钠）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and Analgesic Activity of N,N′-(Ethane-1,2-diyl)bis(spiroazetidin-2ones) Containing Cyclobutane, Cyclopentane or Cyclohexane Fragments

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Synthesis and Analgesic Activity of N,N′-(Ethane-1,2-diyl)bis(spiroazetidin-2ones) Containing Cyclobutane, Cyclopentane or Cyclohexane Fragments

It was found that the Reformatsky reagents, obtained from methyl-1-bromocyclobutane-, 1-bromocyclopentane-, and 1-bromocyclohexanecarboxylates and zinc, react with diimines, derived from ethylenediamine and aromatic aldehydes, in a 2 : 1 molar ratio to form the corresponding bis(spiroazetidin-2-ones). The structure of the obtained compounds was confirmed by single crystal X-ray diffraction analysis. The in vivo analgesic activity of the synthesized compounds was assessed and shown to have pronounced effects, which exceeded those of the reference drug (sodium metamizole).

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.