Synthesis and Characterization of 2,4-Diamino-6-methyl-1,3,5-triazine and 2,4-Diamino-6-phenyl-1,3,5-triazine Doped Polyacid and Their Application to Breast Cancer Studies

Abstract

The current study is involved in the synthesis and characterization of 2,4-diamino-6-methyl-1,3,5-triazine (DMT), and 2,4-diamino-6-phenyl-1,3,5-triazine (DPT) doped polyacid using a co-precipitation method. In addition, polyacid having novel types of structures were synthesized. An efficient and improved procedure for the synthesis of triazine was developed by Silverton-type polyacid. The chemistry of triazine based metal complexes display a variety of reactivity mode and they possess catalytic activities therefore such metal complexes were studied. The doped samples were characterized using spectral techniques such as FT-IR spectra which shows the presence of extended functional groups and SEM morphology exhibits agglomerated structure. XRD results give crystallite size of around 40 nm. Furthermore, the structural and thermal properties of triazine doped polyacid were investigated using UV, TGA and Raman techniques. The antibacterial activity compared to PA and DPT-PA and DMT-PA with improved activity to E. coli and S. aureus was revealed. The anticancer studies of DMT- and DPT-doped polyacid compound was assessed by MTT assay on cell-line MCF-7.