A. V. Zalaltdinova, A. K. Smailov, Yu. M. Sadykova, D. P. Gerasimova, A. S. Gazizov, А. R. Burilov
{"title":"New Cage Phosphonates Containing Halomethyl Group: Synthesis and Some Properties","authors":"A. V. Zalaltdinova, A. K. Smailov, Yu. M. Sadykova, D. P. Gerasimova, A. S. Gazizov, А. R. Burilov","doi":"10.1134/S1070363224120089","DOIUrl":"10.1134/S1070363224120089","url":null,"abstract":"<p>A method was developed for the synthesis of new unsymmetrical cage phosphonates containing terminal halo(bromo, chloro)methyl groups as a result of the reaction of (2-ethoxyvinyl)phosphonic dichloride with halogen-<i>N</i>-(3-hydroxyphenyl)acetamides in trifluoroacetic acid. New cage phosphonates containing one or two phosphonium groups were obtained as a result of the reaction of triphenylphosphine with the corresponding cage phosphonates. It was shown that the type of products formed in this reaction depends on the nature of the halogen atom in the halomethyl group of the cage phosphonate.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3190 - 3195"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. O. Graur, I. I. Graur, P. N. Bourosh, G. G. Balan, O. S. Garbuz, V. I. Tsapkov, A. P. Gulea
{"title":"Synthesis, Structure, and Biological Activity of Mixed-Ligand Copper(II) Coordination Compounds with 2-(3,5-Dibromo-2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide Containing Certain N-Heteroaromatic Bases","authors":"V. O. Graur, I. I. Graur, P. N. Bourosh, G. G. Balan, O. S. Garbuz, V. I. Tsapkov, A. P. Gulea","doi":"10.1134/S1070363224120168","DOIUrl":"10.1134/S1070363224120168","url":null,"abstract":"<p>Сopper(II) nitrate and acetate have reacted in ethanol with 2-(3,5-dibromo-2-hydroxybenzyliden)-<i>N</i>-(prop-2-en-1-yl)hydrazinecarbothioamide (H<sub>2</sub>L) in a 1 : 1 molar ratio with the formation of the [Cu(L)(H<sub>2</sub>O)] and [Cu(Н<sub>2</sub>О)(НL)]<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub><sup>.</sup>EtOH<sup>.</sup>H<sub>2</sub>O complexes, respectively. Their reactions with ethanolic solution of <i>N</i>-heteroaromatic amines (1,10-phenanthroline (1,10-Phen), 2,2′-bipyridyl (2,2′-Bpy), and 3,4-dimethylpyridine (3,4-Lut)) in a 1 : 1 molar ratio have yielded the [Cu(A)(L)] and [Cu(A)(HL)]NO<sub>3</sub> complexes (A = 1,10-Phen; 2,2′-Bpy; 3,4-Lut). The structure of two copper(II) complexes has been established by X-ray diffraction analysis. The obtained complexes have exhibited antimicrobial, antifungal, and antioxidant activities.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3252 - 3262"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Natural Carboxyl-Containing Phenols and Monosaccharides in Radical Oxidation and Complex Formation Reactions","authors":"N. I. Belaya, A. V. Belyi, E. A. Budnikova","doi":"10.1134/S1070363224120120","DOIUrl":"10.1134/S1070363224120120","url":null,"abstract":"<p>It was found by the photocolorimetry method that in acidic media, compositions of natural carboxyl-containing phenols (antioxidants) with monosaccharides (synergists) show an antiradical synergistic effect in reactions with 2,2ʹ-diphenyl-1-picrylhydrazyl, the maximum value of which is typical for binary mixtures of sinapic, gentisic, and ferulic acids with galactose and mannose. It was shown by NMR spectroscopy and difference UV spectroscopy methods that the synergism mechanism consists in the formation of intermolecular hydrogen-bonded phenol-monosaccharide complexes in the ratio of 1:1. A combined model for selecting phenolic-saccharide compositions with high synergistic effect was proposed on the basis of quantum chemical DFT and regression analysis methods.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3223 - 3233"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. I. Baichurin, A. V. Fel’gendler, L. V. Baichurina, O. B. Vuks
{"title":"Nitroacetonitrile in Reactions with Enones","authors":"R. I. Baichurin, A. V. Fel’gendler, L. V. Baichurina, O. B. Vuks","doi":"10.1134/S1070363224120090","DOIUrl":"10.1134/S1070363224120090","url":null,"abstract":"<p>Reactions of nitroacetonitrile with enones, depending on the structure of the latter, lead to the formation of either condensation products at the carbonyl group or Michael adducts, which are capable of undergoing further intra- and intermolecular transformations. The structure of the synthesized products was established using <sup>1</sup>H, <sup>13</sup>C{<sup>1</sup>H} NMR, and IR spectroscopy.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3196 - 3207"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. D. Radaev, E. A. Pushkareva, V. A. Burilov, S. E. Solovieva, I. S. Antipin
{"title":"Convergent Synthesis of OH-Terminated Water-Soluble Dendrimers Based on Imidazole-4,5-dipropargyl-diamide","authors":"D. D. Radaev, E. A. Pushkareva, V. A. Burilov, S. E. Solovieva, I. S. Antipin","doi":"10.1134/S1070363224120107","DOIUrl":"10.1134/S1070363224120107","url":null,"abstract":"<p>In the present work, a first-generation dendron, based on imidazole-4,5-dipropargyl-diamide, was synthesized using the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. By alkylation of imidazole-4,5-dipropargyl-diamide with dibromopropane, a bis-imidazole core was obtained and used for the CuAAC-based synthesis of G<sup>0</sup> and G<sup>1</sup> dendrimers containing terminal OH groups. The structures and compositions of all substances were determined using modern physical methods including two-dimensional NMR and high-resolution mass spectrometry.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3208 - 3216"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. A. Mikhaylov, A. G. Medvedev, P. A. Egorov, N. S. Mayorov, K. Yu. Zhizhin, P. V. Prikhodchenko
{"title":"Laboratory Method for Obtaining Anhydrous Hydrogen Peroxide and Safety Rules for Handling It","authors":"A. A. Mikhaylov, A. G. Medvedev, P. A. Egorov, N. S. Mayorov, K. Yu. Zhizhin, P. V. Prikhodchenko","doi":"10.1134/S1070363224120235","DOIUrl":"10.1134/S1070363224120235","url":null,"abstract":"<p>Hydrogen peroxide is a valuable reagent that is produced on an industrial scale. However, the concentration of commercially available H<sub>2</sub>O<sub>2</sub> does not exceed 70 wt % and usually contains stabilizers that prevent the decomposition of aqueous solutions of H<sub>2</sub>O<sub>2</sub> during storage and transportation. At the same time, there are processes and reactions that require small quantities of pure, anhydrous hydrogen peroxide. This paper describes a two-stage method for producing anhydrous hydrogen peroxide in the laboratory. Distillation of an aqueous solution of hydrogen peroxide in the first stage allows to obtain pure diluted H<sub>2</sub>O<sub>2</sub>. Subsequent distillation of water under vacuum allows to obtain highly concentrated or anhydrous H<sub>2</sub>O<sub>2</sub> in quantities sufficient for laboratory use. This approach is safe only if certain rules are strictly followed when working with concentrated hydrogen peroxide.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3333 - 3339"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuang-Xue Wu, Jing Liu, Bo-Xi Tan, Can He, Wen-Qing Wu, Lu Yu, Pei Li
{"title":"Design, Synthesis, Antibacterial, and Antifungal Activity Evaluation of Novel Pyrimidine Derivatives Incorporating Amide and 1,3,4-Thiadiazole Thioether Moieties","authors":"Shuang-Xue Wu, Jing Liu, Bo-Xi Tan, Can He, Wen-Qing Wu, Lu Yu, Pei Li","doi":"10.1134/S1070363224120375","DOIUrl":"10.1134/S1070363224120375","url":null,"abstract":"<p>In this study, a series of novel pyrimidine derivatives incorporating amide and 1,3,4-thiadiazole thioether moieties were synthesized and their structures were confirmed using <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS analyses. Bioassay results demonstrated that compound 2-{[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]thio}-<i>N</i>-[5-(propylthio)-1,3,4-thiadiazol-2-yl]acetamide exhibited superior antibacterial activity against <i>Xanthomonas oryzae</i> pv<i>. oryzae</i> (<i>Xoo</i>), with an inhibition rate of 100% at a concentration of 200 μg/mL, compared to thiodiazole copper. Meanwhile, compound 2-[(4,6-dimethylpyrimidin-2-yl)thio]-<i>N</i>-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]acetamide displayed remarkable antifungal activity against <i>Gilbertella persicaria</i> (<i>G. persicaria</i>), with an EC<sub>50</sub> value of 6.71 μg/mL, surpassing that of prochloraz. To the best of our knowledge, this study represents the first report on the synthesis and bioactivity evaluation of pyrimidine derivatives incorporating amide and 1,3,4-thiadiazole thioether moieties.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3448 - 3455"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. V. Il’in, M. A. Mamontov, V. N. Kozlova, K. S. Anisimova, M. P. Shulaeva, O. K. Pozdeev, D. R. Islamov
{"title":"Phosphine-Catalyzed α-Umpolung and Vicinal Bis-Addition of Imides and Hydantoins to Methyl Propiolate","authors":"A. V. Il’in, M. A. Mamontov, V. N. Kozlova, K. S. Anisimova, M. P. Shulaeva, O. K. Pozdeev, D. R. Islamov","doi":"10.1134/S1070363224120053","DOIUrl":"10.1134/S1070363224120053","url":null,"abstract":"<p>A series of α-imido- or -hydantoinoacrylates was obtained. The antimicrobial activity of these compounds against gram-positive and gram-negative bacteria and fungi was studied. In addition, data were obtained on the synthesis of 2,3-bisimido- or -bishydantoinopropanoates containing both identical heterocyclic fragments and different ones with α- and β-carbon atoms in one molecule.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3164 - 3172"},"PeriodicalIF":0.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143109677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Halluli, V. A. Sokolov, S. V. Byvsheva, E. V. Ipatova, I. A. Boyarskaya, A. V. Vasilyev
{"title":"Reactions of 3-Arylpopynoic Acid Amides with Arenes in Trifluoromethanesulfonic Acid","authors":"L. Halluli, V. A. Sokolov, S. V. Byvsheva, E. V. Ipatova, I. A. Boyarskaya, A. V. Vasilyev","doi":"10.1134/S1070363225010013","DOIUrl":"10.1134/S1070363225010013","url":null,"abstract":"<p>3-Arylpropynoic acid amides [Ar–C≡C–CONR<sub>2</sub>] in reactions with benzene and electron-donating arenes Ar′H in Brønsted superacid CF<sub>3</sub>SO<sub>3</sub>H (trifluoromethanesulfonic acid, TfOH) give products of mainly<i> anti</i>-hydroarylation of acetylene bond, amides of 3,3-diarylpropenoic acids [Ar(Ar′)C=CHCONR<sub>2</sub>], at room temperature for 1 h with yields of 38–95%. The reactive intermediates of this reaction, O,C-diprotonated forms of amides of 3-arylpropynic acids [Ar–C<sup>+</sup>=CH–C(=O+H)NR<sub>2</sub>], have been studied by quantum chemistry using density functional theory (DFT). According to calculations, the reactive vinyl cationic center in these particles carries a significant positive charge (0.37–0.44 <i>e</i>) and makes a substantial contribution to the HOMO (25.3–37.8%).</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 1","pages":"1 - 8"},"PeriodicalIF":0.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An In Silico Study of Carbon Active Sites for Oxygen Electroreduction on the Nitrogen and Weak-Binding Transition Metals (Cu, Zn) Doped Carbon Nanotubes","authors":"A. V. Kuzmin, B. A. Shainyan","doi":"10.1134/S1070363224120223","DOIUrl":"10.1134/S1070363224120223","url":null,"abstract":"<p>The relative catalytic activity of the vinylic C<sub>2</sub> center adjacent to CuN<sub>4</sub> and ZnN<sub>4</sub> fragments in the copper- and zinc-doped nitrogen anchored (6,6)-armchair carbon nanotubes have been studied theoretically at the ωB97XD/DGDZVP level. The C<sub>2</sub> center is shown to be capable of competing with the metal center at the initial step of molecular oxygen adsorption, demonstrating a lowered overpotential. A detailed analysis of the mechanism and comparison of activation barriers of the reaction on the two competing centers revealed the possibility for the ORR process to occur on the C<sub>2</sub> center of the model CuN<sub>4</sub>-doped CNT catalyst both via the associative and dissociative four-electron pathways. The replacement of Сu for Zn increases the activity of the C<sub>2</sub> center at the initial step. However, the Zn center is slowly but irreversibly oxidized to the stable hydroxide HO*. As a result, the endoergicity of O<sub>2</sub> adsorption and, hence, the probability of 4<i>e</i> associative ORR is increased, but the overpotential for ORR on the C<sub>2</sub> center is slightly decreased from ~1.0 on the non-poisoned to 0.63 V on the Zn-poisoned catalyst.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 12","pages":"3313 - 3323"},"PeriodicalIF":0.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}