Lizhong Wang, Zhuyun Liu, Yunying Sha, Shanshan Yang, Lei Wang
{"title":"固体碱Cs2CO3/ sio2催化乙酸酯与β-硝基苯乙烯[3 + 2]环化反应合成二氢呋喃羧酸酯衍生物","authors":"Lizhong Wang, Zhuyun Liu, Yunying Sha, Shanshan Yang, Lei Wang","doi":"10.1134/S107036322560167X","DOIUrl":null,"url":null,"abstract":"<p>Dihydrofuran is a unique motif found in numerous natural products. Due to the biological and medicinal importance of dihydrofuran derivatives, a great deal of protocols for the synthesis of dihydrofurans have been developed. In this study, a novel approach to the synthesis of substituted 4,5-dihydrofuran-3-carboxylates from a wide range of substituted β-nitrostyrenes and acyl acetates was investigated via solid base Cs<sub>2</sub>CO<sub>3</sub>/SiO<sub>2</sub>-catalyzed [3+2] cycloaddition reactions. The reactions were carried out under mild reaction conditions in DMF medium at 110°C, and the products were cleanly obtained in moderate yields. This procedure provided an environmentally friendly route to functionalized dihydrofurans from readily available substrates under mild reaction conditions.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 7","pages":"1716 - 1725"},"PeriodicalIF":0.8000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solid Base Cs2CO3/SiO2-Catalyzed Synthesis of Dihydrofurancarboxylate Derivatives via [3 + 2] Cyclization Reaction of Acylacetates and β-Nitrostyrenes\",\"authors\":\"Lizhong Wang, Zhuyun Liu, Yunying Sha, Shanshan Yang, Lei Wang\",\"doi\":\"10.1134/S107036322560167X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Dihydrofuran is a unique motif found in numerous natural products. Due to the biological and medicinal importance of dihydrofuran derivatives, a great deal of protocols for the synthesis of dihydrofurans have been developed. In this study, a novel approach to the synthesis of substituted 4,5-dihydrofuran-3-carboxylates from a wide range of substituted β-nitrostyrenes and acyl acetates was investigated via solid base Cs<sub>2</sub>CO<sub>3</sub>/SiO<sub>2</sub>-catalyzed [3+2] cycloaddition reactions. The reactions were carried out under mild reaction conditions in DMF medium at 110°C, and the products were cleanly obtained in moderate yields. This procedure provided an environmentally friendly route to functionalized dihydrofurans from readily available substrates under mild reaction conditions.</p>\",\"PeriodicalId\":761,\"journal\":{\"name\":\"Russian Journal of General Chemistry\",\"volume\":\"95 7\",\"pages\":\"1716 - 1725\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of General Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S107036322560167X\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S107036322560167X","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Solid Base Cs2CO3/SiO2-Catalyzed Synthesis of Dihydrofurancarboxylate Derivatives via [3 + 2] Cyclization Reaction of Acylacetates and β-Nitrostyrenes
Dihydrofuran is a unique motif found in numerous natural products. Due to the biological and medicinal importance of dihydrofuran derivatives, a great deal of protocols for the synthesis of dihydrofurans have been developed. In this study, a novel approach to the synthesis of substituted 4,5-dihydrofuran-3-carboxylates from a wide range of substituted β-nitrostyrenes and acyl acetates was investigated via solid base Cs2CO3/SiO2-catalyzed [3+2] cycloaddition reactions. The reactions were carried out under mild reaction conditions in DMF medium at 110°C, and the products were cleanly obtained in moderate yields. This procedure provided an environmentally friendly route to functionalized dihydrofurans from readily available substrates under mild reaction conditions.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
![Solid Base Cs2CO3/SiO2-Catalyzed Synthesis of Dihydrofurancarboxylate Derivatives via [3 + 2] Cyclization Reaction of Acylacetates and β-Nitrostyrenes](https://img.booksci.cn/booksciimg/2025-8/106316937141791198942.jpg)
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
