Russian Journal of General Chemistry最新文献_第2页

A Greener and Scalable Approach for the Synthesis of MRT67307 and Its AntiInflammatory Activity 一种绿色可扩展的MRT67307合成方法及其抗炎活性

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363224613474

S. Dhavaria, K. Maram, M. R. Kamala Priya, R. Tandon, M. Dhiman

{"title":"A Greener and Scalable Approach for the Synthesis of MRT67307 and Its AntiInflammatory Activity","authors":"S. Dhavaria, K. Maram, M. R. Kamala Priya, R. Tandon, M. Dhiman","doi":"10.1134/S1070363224613474","DOIUrl":"10.1134/S1070363224613474","url":null,"abstract":"Activation of I-kappa-B kinase (IKK) epsilon (IKKε, or IKBKE) and TNK-binding kinase 1 (TBK1) is a potential cellular mechanism that regulates several biological processes. Activation of IKKε/TBK1 axes leads to the phosphorylation of interferon regulatory factor 3 (IRF3) and the subsequent production of interferon-stimulated genes (ISGs). MRT67307 is a potent reversible dual inhibitor of IKKε/TBK1 and has been reported in some studies to understand the relevant disease mechanisms. However, there is no straightforward high-yielding, and greener process reported in the literature for the synthesis of the MRT compound. We are, therefore, reporting herewith a scalable high-yielding, greener process with an overall yield of 11% (calculated without involving several preparative purifications) for the synthesis of MRT compound. The new method is expected to facilitate the availability of MRT compound in larger quantities to carry out required in vitro and in vivo studies in detail and its suitability for relevant disease models. This new synthetic scheme reported in this manuscript may also be helpful in the creation of new synthetic compound libraries starting with the parent chemotype and intermediate compounds.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1048 - 1056"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Oxidation of Benzyl Alcohol to Benzaldehyde under Solvent Free Aerobic Oxidation Condition Using Pd-Supported CeO2 Catalyst pd负载CeO2催化剂在无溶剂有氧氧化条件下选择性氧化苯甲醇制苯甲醛

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225600262

N. Suryam, T. Jagadish, T. Krishna, Anitha R.S.D, S. Swapna, C. Rakesh, D. Mallesh, K. Laxma Reddy

{"title":"Selective Oxidation of Benzyl Alcohol to Benzaldehyde under Solvent Free Aerobic Oxidation Condition Using Pd-Supported CeO2 Catalyst","authors":"N. Suryam, T. Jagadish, T. Krishna, Anitha R.S.D, S. Swapna, C. Rakesh, D. Mallesh, K. Laxma Reddy","doi":"10.1134/S1070363225600262","DOIUrl":"10.1134/S1070363225600262","url":null,"abstract":"In this research, the homogenous PdNPs were developed with varying weight percentages (1 to 4 wt %) on the CeO2 support using a simple impregnation process with a mean size of 5 nm. Furthermore, homogenous PdNPs were examined for the selective oxidation of benzyl alcohol (BA) to benzaldehyde (BZA) in a solvent-free oxidation technique. The developed Pd/CeO2 heterogeneous nanocatalysts were thoroughly studied utilizing various techniques such as P-XRD, TEM, and XPS analysis. Among various Pd loadings, 3 wt % (3Pd/CeO2) catalysts exhibit enhanced catalytic activity for the BA to BZA oxidation process, with 9.5 times greater BA conversion than bare CeO2. Additionally, experiments were conducted to determine the effect of temperature, catalyst weight, reaction time, and catalyst recyclability. The highest benzyl alcohol conversion (95%), benzaldehyde selectivity (99%) and benzaldehyde yield (94%) achieved for 3Pd/CeO2. The 3Pd/CeO2 catalyst not only exhibited superior catalytic activity, but also showed stable activity during recyclability.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1270 - 1279"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metalloprotease-Mediated Hydrothermal Synthesis of Silver Nanoparticles with Enhanced Therapeutic Properties 金属蛋白酶介导的水热合成具有增强治疗性能的纳米银

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S107036322560095X

Z. Khan, M. Shafique, F. Hayat, S. A. Khan, N. Jabeen, S. A. Naz

{"title":"Metalloprotease-Mediated Hydrothermal Synthesis of Silver Nanoparticles with Enhanced Therapeutic Properties","authors":"Z. Khan, M. Shafique, F. Hayat, S. A. Khan, N. Jabeen, S. A. Naz","doi":"10.1134/S107036322560095X","DOIUrl":"10.1134/S107036322560095X","url":null,"abstract":"Silver nanoparticles (AgNPs) exhibit unique physicochemical properties, making them suitable for diverse applications. This study reports an efficient, one-step biosynthesis of AgNPs using a metallo-serine protease as bio-reducing agent via the hydrothermal method. The optimal conditions for biosynthesis were a combination of 600 U/mL enzyme concentration and 1.25% (5 mM) AgNO3, with steam sterilization at 121°C for 2 min. The SEM and EDS revealed spherical morphology of AgNPs with characteristic silver peaks at 3.00–3.5 keV and ~50–350 counts. The X-ray Diffraction confirmed a crystalline structure with an average of 30.07 nm. Furthermore, the FT-IR spectroscopy identified carboxylic acids, amine salts, and alkyl aryl ethers in the bio-capping of the particles. The AgNPs exhibited significant antimicrobial activity against several pathogens at 100 μg/mL and a radical scavenging activity of 68.15% at 500 μg/mL. These findings highlight the efficiency of enzyme-assisted synthesis of metal nanoparticles with enhanced therapeutic properties.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1117 - 1123"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Spectral, and Photochemical Properties of Mg(II), Zn(II), Cu(II), and Mn(III) Octa-(3-fluorophenyl)tetraazaporphyrins Mg（II）、Zn（II）、Cu（II）和Mn（III）八氧基（3-氟苯基）四氮卟啉的合成、光谱和光化学性质

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225600389

N. V. Chizhova, A. E. Likhonina, N. Z. Mamardashvili

引用次数: 0

Eco-Friendly Synthesis of Sesamol-Incorporated Azo Dyes: Anti-Inflammatory Activity and Colourfastness Evaluation 芝麻醇偶氮染料的环保合成：抗炎活性和色牢度评价

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363224610706

J. Raval, B. Patel, V. Patel, B. Dhaduk, J. Lalpara, I. Modasiya, G. Dubal, S. Hadiyal

引用次数: 0

Effect of Carrageenans on Bovine Serum Albumin Thermal Stability 卡拉胶对牛血清白蛋白热稳定性的影响

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225600973

D. R. Khaibrakhmanova, A. A. Nikiforova, A. A. Pokhilenko, I. A. Sedov

引用次数: 0

1-(Pyrrolidin-3-yl)cyclopropanamine-Linked 2-Oxoquinoline Derivatives as Novel Antimicrobial Agents: Synthesis, Characterization, and In Vitro Antimicrobial Evaluation 1-（吡咯烷-3-基）环丙胺- 2-氧喹啉衍生物作为新型抗菌剂：合成、表征和体外抗菌评价

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363224613279

T. Patel, S. K. Kangad, S. M. Sitapara, R. Senta

{"title":"1-(Pyrrolidin-3-yl)cyclopropanamine-Linked 2-Oxoquinoline Derivatives as Novel Antimicrobial Agents: Synthesis, Characterization, and In Vitro Antimicrobial Evaluation","authors":"T. Patel, S. K. Kangad, S. M. Sitapara, R. Senta","doi":"10.1134/S1070363224613279","DOIUrl":"10.1134/S1070363224613279","url":null,"abstract":"This study investigates the antimicrobial potential of 2-oxoquinoline derivatives containing 1-(pyrrolidin-3-yl)cyclopropanamine, highlighting their promise as potent pharmaceutical agents. 2-Oxoquinoline derivatives have attracted considerable interest due to their wide range of therapeutic applications, including anticancer, antibacterial, antiviral, antihypertensive, and antifungal activities. To explore their therapeutic potential, a robust synthetic method was developed to generate a series of N-(1-{1-[2-(6-fluoro-7-methoxy-2-oxoquinolin-1(2H)-yl)ethyl]pyrrolidin-3-yl}cyclopropyl)benzamide derivatives. The structures of the newly synthesized compounds were confirmed using advanced analytical techniques such as LC-MS, 1H, 13C NMR, and elemental analysis. Further, all the synthesized compounds were assessed for their antimicrobial efficacy against various bacterial and fungal strains. The results revealed that certain compounds exhibited significant antibacterial activity, comparable to standard drugs such as chloramphenicol and ciprofloxacin. Additionally, some compounds showed promising antifungal activity, on par with fluconazole and miconazole, indicating their potential for clinical application. This research provides valuable insights into the therapeutic potential of 2-Oxoquinoline derivatives, paving the way for future investigations into their clinical implications for addressing microbial challenges.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1171 - 1181"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Eco-Friendly Compositions Herbicide/Amphiphilic Adjuvant Based on Optimized Structure–Activity Profile 基于优化构效谱的生态友好型除草剂/两亲性佐剂的设计

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225602376

R. A. Kushnazarova, A. B. Mirgorodskaya, N. L. Sharonova, D. M. Kuznetsov, D. A. Terenzhev, O. A. Lenina, E. N. Nikitin, K. A. Petrov, K. O. Sinyashin, L. Ya. Zakharova

{"title":"Design of Eco-Friendly Compositions Herbicide/Amphiphilic Adjuvant Based on Optimized Structure–Activity Profile","authors":"R. A. Kushnazarova, A. B. Mirgorodskaya, N. L. Sharonova, D. M. Kuznetsov, D. A. Terenzhev, O. A. Lenina, E. N. Nikitin, K. A. Petrov, K. O. Sinyashin, L. Ya. Zakharova","doi":"10.1134/S1070363225602376","DOIUrl":"10.1134/S1070363225602376","url":null,"abstract":"To the effectiveness of commercial herbicide, clopyralid, carbamate-containing surfactants were explored as adjuvants. A systematic study of the phytotoxic effect and wetting ability of these compounds by varying the length of the hydrophobic tail and the alkyl substituent in the carbamate fragment (in the presence and absence of an agrochemical) was carried out. Phytotoxic effect was attested in terms of seed germination energy, seed germination, length of roots and seedlings of a number of monocotyledonous and dicotyledonous plants (sweet corn, meadow fescue, watercress, dandelion medicinal). Among the tested surfactants, N-[2-(butylcarbamoyl)oxy)ethyl]-N,N-dimethylhexadecanammonium bromide [Ur-16 (Bu)] demonstrated the optimal characteristics as a potential adjuvant. This surfactant exhibits a high wetting effect, improved transport of pesticide molecules into the plant, relatively low phytotoxicity, and rapid biodegradation. Vegetation experiments demonstrated that the addition of 0.1 wt % Ur-16 (Bu) to the clopyralid solution leads to an increase in the effectiveness of herbicide action by almost 20%, when treating the crops of a weed plant dandelion medicinal. A high selectivity of the proposed herbicidal composition was revealed, i.e., significant inhibition of the growth of dicotyledonous plants (medicinal dandelion) occurred, with no effect observed on monocotyledons plants (meadow fescue). This result contributes to the optimization of functionality/human toxicity/biodegradability ratio, thereby reducing the negative environmental effect.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1257 - 1269"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Properties, and Application of a Polyyne Propeller 聚乙烯醇螺旋桨的合成、性能及应用

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225601097

P. Xu, Y.-L. Zuo, N.-W. Sun, K. Yin, X. Cao, H.-B. Xie, J.-L. Zhang

引用次数: 0

Synthesis of 2,2-Dimethyl-2,3-dihydropyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4(1H)-ones by Reaction of 3-Aminothieno[2,3-b]pyridine-2-carboxamides with Acetone 3-氨基噻吩[2,3-b]吡啶-2-羧酰胺与丙酮反应合成2,2-二甲基-2,3-二氢吡啶[3′，2′：4,5]-噻吩[3,2-d]嘧啶-4(1H)- 1

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225601954

V. V. Dotsenko, S. V. Rudenko, D. Yu. Lukina, A. K. Smirnova, S. G. Krivokolysko, A. Z. Temerdashev, A. S. Harutyunyan, E. G. Paronikyan, N. A. Aksenov, I. V. Aksenova

引用次数: 0