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A Novel Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carbonitrile Derivatives as an Antimicrobial Agent 抗菌药物1,2,3,4-四氢嘧啶-5-碳腈衍生物的新合成方法
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-05-02 DOI: 10.1134/S1070363225605824
Mahesh Auti, Mayur Gawande, Nilesh Halikar, Abdulsaud Abdul Mannan Khan, Sambhaji P. Vartale
{"title":"A Novel Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carbonitrile Derivatives as an Antimicrobial Agent","authors":"Mahesh Auti,&nbsp;Mayur Gawande,&nbsp;Nilesh Halikar,&nbsp;Abdulsaud Abdul Mannan Khan,&nbsp;Sambhaji P. Vartale","doi":"10.1134/S1070363225605824","DOIUrl":"10.1134/S1070363225605824","url":null,"abstract":"<p>The synthesis of substituted 1-{[(<i>E</i>)-benzylidene]amino}-3-{[(1<i>E</i>,2<i>E</i>)-2-(hydroxyimino)-1,2-diphenylethylidene]amino}-4-imino-6-(methylthio)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles was carried out by reacting 2-[bis(methylthio)methylene]malononitrile with (2<i>Z</i>)-<i>N'</i>-[(<i>E</i>)-benzylidene-2-(2-hydroxyimino)-1,2-diphenylethylidene]hydrazine-1-carbothiohydrazide derivatives in dimethyl formamide using anhydrous potassium carbonate. By replacing the methylthio group of new compounds with nitrogen nucleophiles, derivatives were produced. The structure was confirmed by spectral analysis. The newly formed compounds were tested with bacterial and fungal strains. The results obtained by the molecular docking study are in good agreement with the practical analysis of antimicrobial activities.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environment-Friendly and Efficient Synthesis of 2-Aryl Quinoxalines by Using Carbon Microspheres Decorated with Copper Nanoparticles as a Heterogeneous Nanocatalyst 以铜修饰的碳微球作为非均相纳米催化剂环保高效合成2-芳基喹啉
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-05-02 DOI: 10.1134/S1070363225605575
Anand V. Dhirbassi, Adinath D. Dhole, Vitthal G. Kale, Sushama S. Kauthale, László Kótai, Rajendra P. Pawar, Sunil U. Tekale
{"title":"Environment-Friendly and Efficient Synthesis of 2-Aryl Quinoxalines by Using Carbon Microspheres Decorated with Copper Nanoparticles as a Heterogeneous Nanocatalyst","authors":"Anand V. Dhirbassi,&nbsp;Adinath D. Dhole,&nbsp;Vitthal G. Kale,&nbsp;Sushama S. Kauthale,&nbsp;László Kótai,&nbsp;Rajendra P. Pawar,&nbsp;Sunil U. Tekale","doi":"10.1134/S1070363225605575","DOIUrl":"10.1134/S1070363225605575","url":null,"abstract":"<p>This article presents a simple method for synthesizing 2-arylquinoxalines by the condensation of substituted phenacyl bromides with <i>o</i>-phenylenediamines, catalyzed by carbon microspheres decorated with copper nanoparticles as a reusable heterogeneous catalyst. This approach is advantageous due to its environmentally friendly nature, high yield, reduced reaction time, low cost, mild reaction conditions, use of a recyclable heterogeneous catalyst, and simple workup procedure. The catalyst can be easily recovered from the reaction mixture by simple filtration and can be reused up to five catalytic cycles without a significant decrease in catalytic performance, which makes the developed protocol efficient and economical.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
β-Substituted Triphenylphosphonium Chlorides with High Antitumor Activity Prepared by Step by Step Processes 逐级制备具有高抗肿瘤活性的β-取代三苯基氯化物
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-05-02 DOI: 10.1134/S1070363225606222
Anton V. Il’in, Mikhail A. Mamontov, Vera N. Chupina, Olga B. Babaeva, Alexandra D. Voloshina, Andrei V. Bogdanov
{"title":"β-Substituted Triphenylphosphonium Chlorides with High Antitumor Activity Prepared by Step by Step Processes","authors":"Anton V. Il’in,&nbsp;Mikhail A. Mamontov,&nbsp;Vera N. Chupina,&nbsp;Olga B. Babaeva,&nbsp;Alexandra D. Voloshina,&nbsp;Andrei V. Bogdanov","doi":"10.1134/S1070363225606222","DOIUrl":"10.1134/S1070363225606222","url":null,"abstract":"<p>A series of β-substituted N-heterocyclic phosphonium chlorides were prepared under mild stepwise reaction conditions without isolating of intermediate products. They exhibit high activity against two cancer cell lines (M-HeLa and HuTu 80), while having moderate cytotoxicity against normal cell line Wi38, as well as low hemolytic activity. The most active against human cervix epitheloid carcinoma (IC<sub>50</sub> = 7.1 µM) and human duodenal adenocarcinoma (IC<sub>50</sub> = 13.9 µM) was succinimide derivatives bearing alkyl or bicyclic substituents in heterocyclic core.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microstructure Study of (Co)poly(arylene diphthalides) by 13C NMR Spectroscopy 用13C核磁共振光谱研究（Co）聚芳二苯酞的微观结构
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-05-02 DOI: 10.1134/S1070363225605964
Tagir A. Yangirov, Natalia G. Gileva, Akhnef A. Fatykhov, Vladimir A. Kraikin
{"title":"Microstructure Study of (Co)poly(arylene diphthalides) by 13C NMR Spectroscopy","authors":"Tagir A. Yangirov,&nbsp;Natalia G. Gileva,&nbsp;Akhnef A. Fatykhov,&nbsp;Vladimir A. Kraikin","doi":"10.1134/S1070363225605964","DOIUrl":"10.1134/S1070363225605964","url":null,"abstract":"<p>The microstructure of a series of diphenyl oxide–diphenyl sulfide (co)poly(arylene diphthalides) was studied by <sup>13</sup>C NMR spectroscopy. The compositional heterogeneity of these polymers is determined not only by the ratio of aromatic fragments but also by the different stereochemistry of the diphthalide groups along the polymer chain. It was shown that analysis of the split signals of the bridgehead quaternary <i>sp</i><sup>3</sup>-hybridized carbon atoms of the phthalide rings allows the content of homo- (AA and BB) and heterodiads (AB) of <i>racemic</i> and <i>meso</i> configurations in the (co)polymers to be estimated with satisfactory accuracy. The effect of synthesis conditions on the microstructure of (co)poly(arylene diphthalides) was investigated.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Synthesis of 1,2,3-Triazole-quinazoline-acetamide Hybrids; Evaluation of Anticancer Activity and ADMET Analysis 1,2,3-三唑-喹唑啉-乙酰胺杂化物的设计与合成抗癌活性评价及ADMET分析
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-05-02 DOI: 10.1134/S1070363225606015
Devula Venkata Nagarajesh, Dasari Gouthami, Kandala Satyanarayana, Bandari Srinivas
{"title":"Design and Synthesis of 1,2,3-Triazole-quinazoline-acetamide Hybrids; Evaluation of Anticancer Activity and ADMET Analysis","authors":"Devula Venkata Nagarajesh,&nbsp;Dasari Gouthami,&nbsp;Kandala Satyanarayana,&nbsp;Bandari Srinivas","doi":"10.1134/S1070363225606015","DOIUrl":"10.1134/S1070363225606015","url":null,"abstract":"<p>A novel series of 1,2,3-triazole-quinazoline-acetamide hybrids was synthesized and evaluated for anticancer activity against two breast cancer cell lines, MCF-7 and MDA-MB-231, using erlotinib as a standard drug. The results indicate that 2-[4-(4-methoxyphenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-<i>N</i>-(quinazolin-4-yl)acetamide, 2-[4-(3,5-dimethoxyphenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-<i>N</i>-(quinazolin-4-yl)acetamide, 2-[4-(3-methoxyphenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-<i>N</i>-(quinazolin-4-yl)acetamide, and 2-[4-(4-cyanophenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-<i>N</i>-(quinazolin-4-yl)acetamide exhibited higher activity compared to the standard drug. Additionally, the tyrosine kinase inhibitory activity of 2-[4-(4-methoxyphenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-<i>N</i>-(quinazolin-4-yl)acetamide, 2-[4-(3,5-dimethoxyphenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-<i>N</i>-(quinazolin-4-yl)acetamide, and 2-[4-(3-methoxyphenyl)-1<i>H</i>-1,2,3-triazol-1-yl]-<i>N</i>-(quinazolin-4-yl) acetamide was higher compared to erlotinib.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Experimental and Theoretical (DFT) Characterization, Electrochemical Behavior, Antioxidant Evaluation, and Molecular Docking of New Ternary Ni(II) Complexes of Dimethylglyoxime and Some Amino Acids 二甲基乙氧肟与某些氨基酸新型三元Ni（II）配合物的合成、实验与理论表征、电化学行为、抗氧化评价及分子对接
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-04-28 DOI: 10.1134/S1070363225605551
Hadda Bougherra, Omar Berradj, Nour E. Amraoui, Said K. Sidi
{"title":"Synthesis, Experimental and Theoretical (DFT) Characterization, Electrochemical Behavior, Antioxidant Evaluation, and Molecular Docking of New Ternary Ni(II) Complexes of Dimethylglyoxime and Some Amino Acids","authors":"Hadda Bougherra,&nbsp;Omar Berradj,&nbsp;Nour E. Amraoui,&nbsp;Said K. Sidi","doi":"10.1134/S1070363225605551","DOIUrl":"10.1134/S1070363225605551","url":null,"abstract":"<p>Four new Ni(II) ion complexes were created from the interaction of dimethylglyoxime as a primary ligand and amino acids (lysine monohydrochloride, tryptophan, proline, and arginine) as a secondary ligand were investigated using various physicochemical studies such as elemental analysis, molar conductivity, infrared, and UV/vis. The molar conductance data confirm that all the complexes are non-electrolytic. The IR study shows that dimethylglyoxime is coordinated to the metal ion in a bidentate manner through NN donor sites of the oxime function. The amino acid is coordinated through the carboxylate oxygen and the N atom of the amino acid. The electronic spectral data indicated that the synthesized complexes have a square planar geometry, except for the complex with arginine, which has an octahedral structure. A complementary computational study using density functional theory (DFT) calculations was carried out to optimize the structures of the metal complexes and confirm the proposed geometries. The electrochemical behavior of the ligands and their metal complexes was determined by cyclic voltammetry. The study of the antioxidant properties of the complexes using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and molecular docking indicates that the complexes exhibit good antioxidant activity in comparison with ascorbic acid as a positive control.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C–H Functionalization of Isoquinoline with Phosphites and Phosphine Chalcogenides 异喹啉与亚磷酸盐和膦硫属化合物的碳氢功能化
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-04-28 DOI: 10.1134/S1070363225607604
Maxim A. Averkov, Aleksandr V. Shchepochkin, Nadezhda S. Demina, Oleg N. Chupakhin, Valery N. Charushin
{"title":"C–H Functionalization of Isoquinoline with Phosphites and Phosphine Chalcogenides","authors":"Maxim A. Averkov,&nbsp;Aleksandr V. Shchepochkin,&nbsp;Nadezhda S. Demina,&nbsp;Oleg N. Chupakhin,&nbsp;Valery N. Charushin","doi":"10.1134/S1070363225607604","DOIUrl":"10.1134/S1070363225607604","url":null,"abstract":"<p>A simple and efficient method was developed for the synthesis of synthetically challenging 2-[(trifluoromethyl)sulfonyl]-1-phosphoryl-1,2-dihydroisoquinolines and 1-phosphorylisoquinolines, which involves preliminary activation of isoquinoline with trifluoromethanesulfonic anhydride, treatment of the corresponding triflate with phosphorus-containing compounds, and subsequent aromatization of the obtained σ<sup>H</sup>-adducts by elimination of the triflate moiety under basic conditions. The yields of 1,2-dihydroisoquinoline derivatives were up to 67%, and the yields of the aromatization step were up to 81%.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S1070363225607604.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Using a Nano Composite as an Adsorbent to Remove Phenol Red and Bromophenol Blue Dyes from Contaminated Water 纳米复合吸附剂去除水中酚红和溴酚蓝染料的效果
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-04-28 DOI: 10.1134/S1070363225605095
Faleh Z. Alqahtany, Yasser F. El-Aryan, Saad Melhi, Eid H. Alosaimi, Ismail M. Ahmed, Ayman A. O. Younes, Mohamed Y. El-Sayed
{"title":"Effectiveness of Using a Nano Composite as an Adsorbent to Remove Phenol Red and Bromophenol Blue Dyes from Contaminated Water","authors":"Faleh Z. Alqahtany,&nbsp;Yasser F. El-Aryan,&nbsp;Saad Melhi,&nbsp;Eid H. Alosaimi,&nbsp;Ismail M. Ahmed,&nbsp;Ayman A. O. Younes,&nbsp;Mohamed Y. El-Sayed","doi":"10.1134/S1070363225605095","DOIUrl":"10.1134/S1070363225605095","url":null,"abstract":"<p>In this paper, the adsorption behavior of dyes from contaminated water on a novel polyaniline Fe–Ni nano-oxides, prepared by hydrothermal synthesis, was investigated. Polyaniline Fe–Ni nano-oxides were characterized by means of Fourier transform infrared spectroscopy, thermogravimetric differential thermal analysis, and X-ray diffraction. As the solution’s reaction temperature rises, so does the distribution coefficient (<i>K</i><sub>d</sub>). Batch systems were used for the adsorption investigations. The results demonstrated that the amount of bromophenol blue and phenol red adsorbed decreased as the pH increased. The isothermal data demonstrated an excellent match to the Langmuir than Freundlich models, pseudo-second-order kinetics were determined to most accurately represent the kinetic data. The Langmuir model calculated a maximal sorption capacity of 181.16 and 22.95 mg/g for adsorption of bromophenol blue and phenol red respectively. The average particle size was measured to be 26.76 nm.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Antibacterial Activity of Some Acetophenone Derivatives 苯乙酮类衍生物的合成及抗菌活性研究
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-04-28 DOI: 10.1134/S1070363225605381
Ibrahim G. Mamedov, Farid N. Naghiyev, Nurana F. Aliyeva, Victor N. Khrustalev, Khudaverdi G. Ganbarov
{"title":"Synthesis and Antibacterial Activity of Some Acetophenone Derivatives","authors":"Ibrahim G. Mamedov,&nbsp;Farid N. Naghiyev,&nbsp;Nurana F. Aliyeva,&nbsp;Victor N. Khrustalev,&nbsp;Khudaverdi G. Ganbarov","doi":"10.1134/S1070363225605381","DOIUrl":"10.1134/S1070363225605381","url":null,"abstract":"<p>New compounds—[4-hydroxy-2,6-bis-(3-methoxyphenyl)-4-phenylcyclohexane-1,3-diyl]bis(phenylmethanone), 4′′-methoxy-5′-oxo-<i>N</i>-phenyl-2′,3′,4′,5′-tetrahydro-[1,1′:3′,1′′-terphenyl]-4′-carboxamide, and 4′′-nitro-5′-oxo-<i>N</i>-phenyl-2′,3′,4′,5′-tetrahydro-[1,1′:3′,1′′-terphenyl]-4′-carboxamide—were synthesized by the reaction of acetophenone with aldehydes and acetoacetanilide. Subsequently, their antibacterial activity against pathogenic bacteria was studied. The structure of the products was determined using NMR spectroscopy. A probable reaction mechanism for the formation of the six-membered ring was proposed.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Cytotoxic Properties of 3,4-Diaryl-5-morpholinoisoxazole as an Analogue of Combretastatin A4 Combretastatin A4类似物3,4-二芳基-5-morpholinoisoxazole的合成及细胞毒性研究
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2026-04-28 DOI: 10.1134/S1070363226600840
Georgy L. Karetnikov, Dmitry A. Guk, Anastasiia A. Filatova, Margarita A. Vorobeva, Dmitry A. Skvortsov, Oksana B. Bondarenko
{"title":"Synthesis and Cytotoxic Properties of 3,4-Diaryl-5-morpholinoisoxazole as an Analogue of Combretastatin A4","authors":"Georgy L. Karetnikov,&nbsp;Dmitry A. Guk,&nbsp;Anastasiia A. Filatova,&nbsp;Margarita A. Vorobeva,&nbsp;Dmitry A. Skvortsov,&nbsp;Oksana B. Bondarenko","doi":"10.1134/S1070363226600840","DOIUrl":"10.1134/S1070363226600840","url":null,"abstract":"<p>A method for the synthesis of 3,4-diaryl-5-morpholinoisoxazoles was developed, featuring the optimization of reaction conditions to introduce a morpholine moiety at the 5-position of 5-chloroisoxazoles. The representative compound <b>9</b> was prepared and evaluated <i>in vitro</i>, demonstrating moderate water solubility along with cytotoxic activity against selected cell lines. This modification strategy provides a viable approach for further structural diversification of combretastatin A4 analogues within the isoxazole series, enabling the expansion of a library of heterocyclic derivatives with improved physicochemical properties.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 6","pages":""},"PeriodicalIF":0.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1134/S1070363226600840.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147752556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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