{"title":"金属卟啉高效成像探针的弛豫性和细胞毒性研究（综述）","authors":"J. Sivasankari, M. Amutha Selvi","doi":"10.1134/S1070363225601863","DOIUrl":null,"url":null,"abstract":"<p>Magnetic resonance imaging has evolved as an effective diagnostic tool to localize unhealthy tissues which has induced the development of pharma products—contrast agents. Due to their paramagnetism, it increases the relaxation rate of water protons in the surrounding tissues. The porphyrin skeleton has been used for the past few decades due to its unique affinity towards tumor tissues to function in this strategy. Metalloporphyrins like gadolinium and manganese metals with different bioactive groups conjugated to enhance the relaxation time discussed in this review. The various ranges of relaxivity depending on the metal and bioactive ligand that chelated to porphyrin and its potential to cause cancer cell death with different cancer cell lines have been discussed.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 9","pages":"2321 - 2335"},"PeriodicalIF":0.8000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relaxivity and Cytotoxicity Studies of Efficient Imaging Probes of Metalloporphyrins (A Mini-Review)\",\"authors\":\"J. Sivasankari, M. Amutha Selvi\",\"doi\":\"10.1134/S1070363225601863\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Magnetic resonance imaging has evolved as an effective diagnostic tool to localize unhealthy tissues which has induced the development of pharma products—contrast agents. Due to their paramagnetism, it increases the relaxation rate of water protons in the surrounding tissues. The porphyrin skeleton has been used for the past few decades due to its unique affinity towards tumor tissues to function in this strategy. Metalloporphyrins like gadolinium and manganese metals with different bioactive groups conjugated to enhance the relaxation time discussed in this review. The various ranges of relaxivity depending on the metal and bioactive ligand that chelated to porphyrin and its potential to cause cancer cell death with different cancer cell lines have been discussed.</p>\",\"PeriodicalId\":761,\"journal\":{\"name\":\"Russian Journal of General Chemistry\",\"volume\":\"95 9\",\"pages\":\"2321 - 2335\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of General Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070363225601863\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363225601863","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Relaxivity and Cytotoxicity Studies of Efficient Imaging Probes of Metalloporphyrins (A Mini-Review)
Magnetic resonance imaging has evolved as an effective diagnostic tool to localize unhealthy tissues which has induced the development of pharma products—contrast agents. Due to their paramagnetism, it increases the relaxation rate of water protons in the surrounding tissues. The porphyrin skeleton has been used for the past few decades due to its unique affinity towards tumor tissues to function in this strategy. Metalloporphyrins like gadolinium and manganese metals with different bioactive groups conjugated to enhance the relaxation time discussed in this review. The various ranges of relaxivity depending on the metal and bioactive ligand that chelated to porphyrin and its potential to cause cancer cell death with different cancer cell lines have been discussed.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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