Russian Journal of General Chemistry最新文献_第3页

Adamantylfuroylphosphonates: Synthesis and Further Transformations 金刚烷基氟酰膦酸盐：合成及进一步转化

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225600584

L. M. Pevzner, M. L. Petrov, A. V. Stepakov

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Microwave Assisted Synthesis and Biological Studies of Phenothiazine-Based Imidazole Derivatives 吩噻嗪基咪唑衍生物的微波合成及生物学研究

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225600249

P. Idavathi Gunaseeli, Y. Jaya Vinse Ruban, K. Venkatesan

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2D QSAR, Design, ADMET Prediction, and Docking Study of Novel Coumarin Derivatives as α-Glucosidase Inhibitors 新型香豆素衍生物α-葡萄糖苷酶抑制剂的2D QSAR、设计、ADMET预测及对接研究

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363224608342

L. Naanaai, A. El Aissouq, Y. El Allouche, S. El Rhabori, M. Bouachrine, H. Zaitan, and F. Khalil

{"title":"2D QSAR, Design, ADMET Prediction, and Docking Study of Novel Coumarin Derivatives as α-Glucosidase Inhibitors","authors":"L. Naanaai, A. El Aissouq, Y. El Allouche, S. El Rhabori, M. Bouachrine, H. Zaitan, and F. Khalil","doi":"10.1134/S1070363224608342","DOIUrl":"10.1134/S1070363224608342","url":null,"abstract":"A new series of α-glucosidase inhibitors was the subject of investigations using molecular modeling, such as molecular docking, 2D-QSAR, and ADMET prediction. The aim is to obtain new α-glucosidase inhibitors with high activities. The 2D-QSAR model generated was obtained using descriptors from the MOE software. The best model, utilizing the multiple linear regression (MLR) method, yielded 0.91 for the determination coefficient (r2) and 0.10 for the root-mean-square error (RMSE). The developed model’s predictive power was assessed using both internal and external validations, which yielded the Q2 and R2test values of 0.80 and 0.81, respectively. Using the ADMET, it was possible to assess a compound's oral activity prediction. Additionally, molecular docking was used to test the affinity of the ligands (coumarin derivatives with an oxime ester) to the α-glucosidase receptor. Finally, this study may open the door to the creation of coumarin compounds that can inhibit the α-glucosidase enzyme.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1007 - 1024"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis of Diphthalonitriles Based on 3,3′,5,5′-Tetrasubstituted Derivatives of 2,2′- and 4,4′-Biphenyldiols 2,2 ' -和4,4 ' -联苯二醇3,3 ',5,5 ' -四取代衍生物合成二苯二腈

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225601152

V. L. Baklagin, V. V. Bukhalin, E. A. Zyuzin, I. G. Abramov

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New Cross-Conjugated Isoquinolines from 4H-Thieno[3,2-b]pyrroles 由4H-Thieno[3,2-b]吡咯合成的新型交叉共轭异喹啉类化合物

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225601395

S. A. Torosyan, Z. F. Nuriakhmetova, F. A. Gimalova, A. N. Lobov, M. S. Miftakhov

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Hybrid Multicyclophanes Containing para-and meta-Cyclophane Residues: Synthesis and Supramolecular Self-Assembly 含对环烷和间环烷残基的杂化多环烷：合成和超分子自组装

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225602339

D. N. Shurpik, A. F. Gazizova, P. L. Padnya, I. I. Stoikov

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LDHs Catalysts for CO2 Photocatalytic Reduction (A Review) 光催化还原CO2的LDHs催化剂（综述）

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225600614

Y. Guo, W. Ya, S. Cheng, Z. Ni, R. Zhang

{"title":"LDHs Catalysts for CO2 Photocatalytic Reduction (A Review)","authors":"Y. Guo, W. Ya, S. Cheng, Z. Ni, R. Zhang","doi":"10.1134/S1070363225600614","DOIUrl":"10.1134/S1070363225600614","url":null,"abstract":"Photocatalytic CO2 reduction is considered a promising green approach that can concurrently achieve sustainable energy production and mitigate climate change. However, the sluggish reaction kinetics and the complexity of multiple reaction pathways present substantial challenges to enhancing product generation rates and selectivity. Among various catalysts, layered double hydroxides (LDHs), as anion intercalation materials, have garnered considerable attention due to their ultrathin layered structure, tunable chemical composition, and modifiable transition metal d-electron configuration. These properties endow LDHs with broad spectral absorption, efficient carrier migration, and abundant active sites. In recent years, a considerable body of research has emerged focusing on LDHs catalyst; however, comprehensive reviews and summaries of these advancements remain scarce. This paper aims to systematically review the progress in regulating LDH structures for enhanced photocatalytic CO2 reduction. It begins by introducing the photocatalytic CO2 reduction mechanism and the structural characteristics of LDH photocatalysts. Subsequently, it summarizes methods for modifying the electronic structure of LDH photocatalysts through defect engineering, morphology control, single-atom modification, element doping, and heterojunction construction. These optimizations could improve light absorption, electron-hole separation and migration, and surface reduction reactions, thereby enhancing photocatalytic performance. Finally, the paper addresses the challenges faced by LDH photocatalytic systems and outlines future research directions.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 5","pages":"1280 - 1293"},"PeriodicalIF":0.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Synthesis of Phosphoryl-Substituted Cyclopropanes Based on Cyano-Activated CH Acids. 1 : 2 Adduct-Product of O- and C-Alkylation of Dimedone 基于氰基活化CH酸的磷酸基取代环丙烷的合成。二美酮O-和c -烷基化1:1加合产物

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-05-21 DOI: 10.1134/S1070363225600390

G. Ts. Gasparyan, A. S. Bichakhchyan, L. V. Derdzyan, Z. Z. Mardiyan, T. T. Khachatryan, H. A. Karapetyan, L. R. Gasparyan, A. S. Poghosyan

引用次数: 0

Biochar Derived from Curry Leaves for Cr(VI) Removal from Wastewater and Subsequent Use as a Supercapacitor Electrode 从咖喱叶中提取生物炭去除废水中的铬（VI）并随后用作超级电容器电极

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-04-25 DOI: 10.1134/S1070363225600195

A. Sakthivel, M. Veera Vignesh, K. Ganesan, G. Sankareshshree, R. P. Siddharthan, J. Dhaveethu Raja

{"title":"Biochar Derived from Curry Leaves for Cr(VI) Removal from Wastewater and Subsequent Use as a Supercapacitor Electrode","authors":"A. Sakthivel, M. Veera Vignesh, K. Ganesan, G. Sankareshshree, R. P. Siddharthan, J. Dhaveethu Raja","doi":"10.1134/S1070363225600195","DOIUrl":"10.1134/S1070363225600195","url":null,"abstract":"Addressing energy and environmental problems through sustainable routes is currently a vibrant field. This study focuses on achieving clean water by removing Cr(VI) using sustainable adsorbents, i. e., biochar derived from the fallen curry leaves. Intriguingly, the spent biochar is used as a supercapacitor electrode to find a sustainable solution for energy storage. Initially, biochar is prepared from fallen curry leaves by pyrolysis under an oxygen-deficient environment and characterised using multiple techniques. The prepared biochar could remove ~50 ppm of Cr(VI) from 50 mL of contaminated wastewater under optimized conditions. 1 g of CLB effectively removes 49.8 ppm of Cr(VI) from 140 ppm of the initial Cr(VI) concentration with 120 min residence time and simultaneously converts harmful Cr(VI) into harmless Cr(III). The structural, textural, and morphological properties of the prepared biochar are correlated to its adsorption capacity. Advantageously, the spent biochar, i. e., Cr(VI)-adsorbed biochar, is used as an electrode material that displays a remarkable specific capacitance of 188.44 F/g. The charged capacitors lighten the LED devices glowing brightly beyond 2.75 min. Notably, the prepared supercapacitor devices show the same efficiency during the multiple charging-discharging cycles. This work might add valuable insights into identifying sustainable solutions for achieving clean energy and a healthy environment.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"914 - 926"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Ergosterol Peroxide Prodrug Based on Glutathione Response and Evaluation of Its Antitumor Effect 基于谷胱甘肽反应的过麦角甾醇前药制备及其抗肿瘤作用评价

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-04-25 DOI: 10.1134/S1070363225600158

R. Luo, L. M. Hou, Q. Wang, Y. Lin, S. Q. Deng, L. Wang, M. Bu

{"title":"Preparation of Ergosterol Peroxide Prodrug Based on Glutathione Response and Evaluation of Its Antitumor Effect","authors":"R. Luo, L. M. Hou, Q. Wang, Y. Lin, S. Q. Deng, L. Wang, M. Bu","doi":"10.1134/S1070363225600158","DOIUrl":"10.1134/S1070363225600158","url":null,"abstract":"Combining antitumor drugs with fluorescent groups to form therapeutic prodrugs has important application value in cancer treatment. In this study, we designed and synthesized a novel anticancer therapeutic prodrug, 2-(benzo[d]thiazol-2-yl)-4-methoxyphenyl 4-{[4-(ergosterol peroxide-3-yl-oxy)-4-oxobutyl]disulfaneyl}butanoate. The synthesis was achieved by covalently linking ergosterol peroxide (EP) and 2-(benzo[d]thiazol-2-yl)-4-methoxyphenol through a disulfide (S–S) bond. The reaction of the prodrug with high-concentration GSH in tumor tissues broke the disulfide bond, dissociating it into free EP and activated fluorescent BTMP, enabling the visual monitoring of the drug. A series of spectral analyses showed that 2-(benzo[d]thiazol-2-yl)-4-methoxyphenyl 4-{[4-(ergosterol peroxide-3-yl-oxy)-4-oxobutyl]disulfaneyl}butanoate could be specifically activated by high-concentration GSH and had good stability. Cytotoxicity assays showed that it had strong inhibitory activity against breast cancer MCF-7 cells but low toxicity toward human normal breast cells (MCF-10A). In addition, it could induce apoptosis and enable visual tracking in MCF-7 cells. Consequently, the specific drug-release behavior of 2-(benzo[d]thiazol-2-yl)-4-methoxyphenyl 4-{[4-(ergosterol peroxide-3-yl-oxy)-4-oxobutyl]disulfaneyl}butanoate within tumors renders it a highly promising prodrug candidate. This approach thus offers a viable strategy for tumor diagnosis and treatment.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"902 - 913"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0