Russian Journal of General Chemistry最新文献_第3页

Features of Cycloaddition Reaction Between Me2Ge=Ge: and Formaldehyde

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224611116

Jingsong Gu, Huilian Xu, Xiuhui Lu

引用次数: 0

Molecular Docking and Spectroscopic Exploring of the Binding Intermolecular between BSA with Complex of Zirconium

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224612894

H. Dezhampanah, A. M. Moghaddam Pour

{"title":"Molecular Docking and Spectroscopic Exploring of the Binding Intermolecular between BSA with Complex of Zirconium","authors":"H. Dezhampanah, A. M. Moghaddam Pour","doi":"10.1134/S1070363224612894","DOIUrl":"10.1134/S1070363224612894","url":null,"abstract":"In this study, the mechanism of the binding interaction of Zr(CUR), a novel six-coordinate complex of zirconium with a curcumin ligand and bovine serum albumin (BSA), was elucidated via fluorescence spectroscopy, Fourier transform infrared spectroscopy and molecular modeling methods. The analysis indicated that Zr(CUR) could effectively quench the endogenous fluorescence of BSA, forming a 1 : 1 complex with a static quenching mechanism. The distance between the donor (BSA) and acceptor [Zr(CUR)] was determined to be 1.19 nm on the basis of Forester’s theory of nonradiative energy transfer. The results of the infrared absorption spectrum revealed that the secondary structure of BSA changed. The molecular docking results demonstrated that the Zr(CUR) with the minimum binding energy is at position IIIA. Furthermore, as shown by the docking study, Zr(CUR) has several hydrogen bonds and van der Waals contacts with BSA. The synchronous fluorescence and Fourier transform infrared spectroscopy data revealed that Zr(CUR) could lead to conformational changes in BSA, which could affect its biological functions.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 3","pages":"654 - 662"},"PeriodicalIF":0.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Exploring Antiproliferative Activity of Some Pyrazole-Bearing Heterocycles: DFT, Molecular Docking, and ADME Study

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363225600134

S. K. Ramadan, S. M. Gomha, E. A. E. El-Helw

{"title":"Synthesis and Exploring Antiproliferative Activity of Some Pyrazole-Bearing Heterocycles: DFT, Molecular Docking, and ADME Study","authors":"S. K. Ramadan, S. M. Gomha, E. A. E. El-Helw","doi":"10.1134/S1070363225600134","DOIUrl":"10.1134/S1070363225600134","url":null,"abstract":"Worldwide, millions of people are impacted by cancer. In vitro antiproliferative activity of some pyrazole-bearing N-heterocycles was tested against HCT116 and MCF7 cancer cell lines, which showed the most efficacy of pyranoquinoline and chromene. Among molecular docking simulation towards cyclin-dependent kinase-2 (CDK2) protein, pyranoquinoline had the best docking, compared to doxorubicin and roscovitine (RRC), hinting at a possible mechanism of action (interactions with common amino acids). DFT simulation displayed unprecedented insights into these compounds' electronic properties and structure-activity relationships. Pyranoquinoline had the greatest softness and the lowest energy gap, increasing its reactivity to radical surface interactions. Compounds with notable antiproliferative activity were those with high electrophilicity values. Modeling pharmacokinetics simulation also revealed the ideal drug-likeness and oral bioavailability features of compounds. This research may aid in the creation of innovative, highly effective agents used in the battle against cancer and other infections in the future.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 3","pages":"732 - 741"},"PeriodicalIF":0.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfonated Biochar Derived from Eucalyptus Bark as Natural Catalyst in the Biginelli Reaction

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224613048

K. Bouafina, F. Belferdi, F. Bouremmad

引用次数: 0

Targeted Breast Cancer Combat: The Pioneering Role of Hesperidin-Infused pH and Thermosensitive Nanoparticles

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224611864

E. Küçük, M. Yıldırım, Ö. Acet, V. Karakoç, S. Yalın

{"title":"Targeted Breast Cancer Combat: The Pioneering Role of Hesperidin-Infused pH and Thermosensitive Nanoparticles","authors":"E. Küçük, M. Yıldırım, Ö. Acet, V. Karakoç, S. Yalın","doi":"10.1134/S1070363224611864","DOIUrl":"10.1134/S1070363224611864","url":null,"abstract":"This study aimed to improve the bioavailability and increase the therapeutic efficacy of Hes against breast cancer by using pH and temperature-sensitive smart polymeric nanoparticles. Poly(2-hydroxyethyl methacrylate) (pHEMA) is a synthetic polymer composed of HEMA monomers, suitable for medical applications due to its biocompatibility and cytocompatibility. Vinyl imidazole and poly(N-isopropylacrylamide) copolymers were used to impart pH sensitivity and temperature-sensitive properties to the pHEMA polymer, respectively. Both non-loaded and hesperidin-loaded smart nanoparticles (HesSNPs) were characterized by FTIR. The particle size and size distribution of HesSNPs were determined by dynamic light scattering analysis. Scanning electron microscopy was used to determine morphological characterization. Additionally, the effects of HesSNPs on cell proliferation, apoptosis, and cell cycle in breast cancer were also examined. The MTT assay was used to evaluate the cytotoxic effects of HesSNPs on MCF-7 cells at different concentrations (10–20 µM) for 24 h. It was found that MCF-7 cell proliferation in HesSNPs-1, HesSNPs-2, HesSNPs-3, and free hesperidin group decreased statistically significantly compared to the control group, depending on the dose (p < 0.05). The apoptotic effect was examined with the Annexin V-PI Staining Method in flow cytometry. The increase in the rate of apoptosis cells in the experimental groups was found to be statistically significant compared to the control group. Furthermore, it was determined that the nanoparticles induced apoptosis and increased the number of cells arrested in the G1 phase of the cell cycle.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 3","pages":"562 - 571"},"PeriodicalIF":0.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Activity Evaluation of Endogenous Hydrogen Sulfide Inhibitor of MRSA

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-27 DOI: 10.1134/S1070363224612638

W. F. He, J. X. Wang, P. Y. Gao, D. Q. Li, H. Jin, C. F. Liu, X. G. Liu

{"title":"Design, Synthesis, and Activity Evaluation of Endogenous Hydrogen Sulfide Inhibitor of MRSA","authors":"W. F. He, J. X. Wang, P. Y. Gao, D. Q. Li, H. Jin, C. F. Liu, X. G. Liu","doi":"10.1134/S1070363224612638","DOIUrl":"10.1134/S1070363224612638","url":null,"abstract":"Eighteen indole target compounds were synthesized from 3-(6-bromo-3-indolyl)propionic acid. The chemical structures were determined by 1H NMR, 13C NMR, and HRMS. Bioactivity assays revealed that 3-(6-bromo-3-indolyl)-N-(3-fluorophenyl)propenamide exhibited the most potent inhibitory effect on methicillin-resistant Staphylococcus aureus (MRSA) endogenous H2S at a concentration of 40 μM, with an inhibitory rate of 80.2±0.92%. The results of antibacterial experiments showed that co-administering partial target compounds with oxacillin sodium reduced the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of MRSA by 50% when compared to oxacillin sodium alone. Further studies revealed that the synergistic antimicrobial mechanism is closely related to the Fenton reaction. The results of the cytotoxicity assay showed that 3-(6-bromo-3-indolyl)-N-(4-chlorobenzyl)propenamide had the least inhibitory effect on BEAS-2B cells. The experimental results of this study may provide references and ideas for the treatment of MRSA infection.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 3","pages":"606 - 619"},"PeriodicalIF":0.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, Antifungal, and Nematocidal Activities of Novel Pyrimidine Derivatives Incorporating an 1,1,2-Trifluoro-1-butene Moiety

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S107036322461264X

Yan-Ling Ren, Ling-Ling Xiao, Tao Wang, Hai-Yan Wang, Shou-Mei Wan, Lu Yu, Pei Li

{"title":"Design, Synthesis, Antifungal, and Nematocidal Activities of Novel Pyrimidine Derivatives Incorporating an 1,1,2-Trifluoro-1-butene Moiety","authors":"Yan-Ling Ren, Ling-Ling Xiao, Tao Wang, Hai-Yan Wang, Shou-Mei Wan, Lu Yu, Pei Li","doi":"10.1134/S107036322461264X","DOIUrl":"10.1134/S107036322461264X","url":null,"abstract":"In this study, a series of novel pyrimidine derivatives incorporating an 1,1,2-trifluoro-1-butene moiety were synthesized and their structures were confirmed by 1H NMR, 13C NMR, and HRMS. The bioassay results demonstrate that 4-methyl-2-[(3,4,4-trifluorobut-3-en-1-yl)thio]-6-(trifluoromethyl)pyrimidine exhibits comparable in vitro antifungal activity against Aspergillus niger (64.55 and 48.85%, respectively) at concentrations of 100 and 50 μg/mL when compared to Prochloraz. Additionally, 4-methyl-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-6-(trifluoromethyl)pyrimidine demonstrates superior nematocidal activity against Caenorhabditis elegans at concentrations of 100 and 50 μg/mL after 48 h with corrected mortality rates of 89.65 and 79.47%, respectively, surpassing those observed for ethoprophos. To the best of our knowledge, this study presents the first report on the synthesis and antifungal and nematocidal activities of novel pyrimidine derivatives incorporating an 1,1,2-trifluoro-1-butene moiety.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 2","pages":"511 - 517"},"PeriodicalIF":0.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Assisted Facile Synthesis of 1,2-Benzisoxazoles, Isoxazoloquinolines, and Isothiazoloquinolines in [BMIM(SO2Cl)][OTs] Ionic Liquid as a Recyclable System

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S1070363224611943

I. Jamadar, R. B. Manami, S. Kurahatti, A. Anchi, V. Jadhav, R. G. Kalkhambkar, M. Kurkuri, M. S. Refat, A. M. Alsuhaibani

引用次数: 0

Experimental and Theoretical Studies for Noncovalent Interactions Analysis of 2-Mercaptopyrimidine Derivative and Their Antimicrobial Activities

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S1070363224611773

A. Jaiswal, M. Mishra, J. Singh, R. K. Upadhyay, A. K. Pal, R. Kumar

引用次数: 0

Tetrakis-benzimidazoles as Tetradentate to Octadentate Ligands: Their Properties, Applications, and Metal Complexes (A Review)

IF 0.9 4区化学

Russian Journal of General Chemistry Pub Date : 2025-03-26 DOI: 10.1134/S107036322461216X

A. Tavman

{"title":"Tetrakis-benzimidazoles as Tetradentate to Octadentate Ligands: Their Properties, Applications, and Metal Complexes (A Review)","authors":"A. Tavman","doi":"10.1134/S107036322461216X","DOIUrl":"10.1134/S107036322461216X","url":null,"abstract":"Tetrakis-benzimidazoles are tetrapodal compounds with multidentate ligand properties, including at least tetradentate provided by the C=N nitrogen atoms in each benzimidazole unit, and they can be obtained in their many derivatives. There are also tetrakis-benzimidazole derivatives that contain atoms such as N and O in the bridge units and thus exhibit various donor properties up to octadentate. Because of these properties, they are similar to EDTA (ethylenediamminetetraacetic acid) which is a medication used in the management and treatment of heavy metal toxicity, and attract the attention of researchers. The applications of tetrakis-benzimidazole derivatives and various metal complexes in many fields such as corrosion inhibitor, catalyst, enzyme inhibitor, superoxide dismutase, catalase activity, superoxide oxidase, DNA affinity, determination of H2O2, were investigated. In this study, a comprehensive review was conducted on tetrakis-benzimidazoles: their synthesis routes, properties, various metal complexes, features and application areas have been reviewed and compiled in order to be useful for researchers who will work in this field.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 2","pages":"436 - 490"},"PeriodicalIF":0.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0