Russian Journal of General Chemistry最新文献_第3页

Molecular Hybridization-Guided Design and Synthesis of Novel Pyrazolylidene–Thiazolopyrimidine Derivatives 分子杂交引导下新型吡酰基噻唑嘧啶衍生物的设计与合成

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-21 DOI: 10.1134/S1070363226602784

Zehor Belkacem, Abdelkader Naouri, Rébat Moulkrere Bachar, Mokhtar Fodili, Mokhtar Benalia, Christian Lherbet, Pascal Hoffmann

{"title":"Molecular Hybridization-Guided Design and Synthesis of Novel Pyrazolylidene–Thiazolopyrimidine Derivatives","authors":"Zehor Belkacem, Abdelkader Naouri, Rébat Moulkrere Bachar, Mokhtar Fodili, Mokhtar Benalia, Christian Lherbet, Pascal Hoffmann","doi":"10.1134/S1070363226602784","DOIUrl":"10.1134/S1070363226602784","url":null,"abstract":"The development of hybrid heterocyclic scaffolds represents an effective strategy for expanding the structural diversity of heterocyclic compounds. Herein, we report the synthesis of a new series of pyrazolylidene–thiazolopyrimidine hybrids through a concise and efficient synthetic route. The methodology involves the preparation of a diketopyrazolinone intermediate from dehydroacetic acid, followed by cyclocondensation with substituted 1,3,4-thiadiazol-2-amines or benzothiazol-2-amine in n-butanol under mild acidic conditions. The synthesized compounds were isolated in satisfactory yields (45–70%) and their structures were confirmed by 1H and 13C NMR spectroscopy and mass spectrometry. A plausible cyclocondensation mechanism is proposed to account for the formation of the fused heterocyclic products. The reported synthetic protocol provides convenient access to a novel class of pyrazolylidene–thiazolopyrimidine hybrids that may constitute valuable scaffolds for future medicinal chemistry applications.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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New Isatin Hydrazones Exhibiting Activity Against Certain Gram-Positive Antropopatogens 新的Isatin腙具有抗某些革兰氏阳性人源的活性

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-21 DOI: 10.1134/S107036322660325X

Andrei V. Bogdanov, Alexandra D. Voloshina, Anastasia S. Sapunova, Julia K. Voronina

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Fabrication of Biochar-Modified Alginate Beads and Study of Its Potential for Eliminating SDS from Water 生物炭修饰海藻酸盐微球的制备及其去除水中SDS的潜力研究

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-21 DOI: 10.1134/S1070363226601262

Smita Tiwari, Vijita Diwan, Santosh Kumar Sar

{"title":"Fabrication of Biochar-Modified Alginate Beads and Study of Its Potential for Eliminating SDS from Water","authors":"Smita Tiwari, Vijita Diwan, Santosh Kumar Sar","doi":"10.1134/S1070363226601262","DOIUrl":"10.1134/S1070363226601262","url":null,"abstract":"Hydrogel-based adsorbents have attracted increasing attention for the removal of surfactants from wastewater; however, limitations related to adsorption efficiency and material cost remain insufficiently addressed. This study investigates the synthesis and performance of biochar-modified alginate hydrogel beads derived from banana peel waste for the removal of sodium dodecyl sulfate (SDS) from aqueous solutions. The adsorbent was characterized using scanning electron microscopy and Fourier transform infrared spectroscopy to examine surface morphology and functional groups involved in adsorption. Batch adsorption experiments were conducted to evaluate the effects of pH, contact time, adsorbent dosage, and initial SDS concentration. Optimal adsorption conditions were identified at pH 8, initial concentration of 20 mg/L, adsorbent dosage of 0.02 g/50 mL, and contact time of 60 min, yielding a maximum adsorption capacity of 64.93 mg/g. Adsorption equilibrium data were best described by the Langmuir isotherm model, indicating monolayer adsorption, while kinetic analysis showed good agreement with the pseudo-second-order model, suggesting chemisorption as the dominant mechanism. Thermodynamic parameters revealed a negative Gibbs free energy change, confirming the spontaneous nature of the adsorption process. Regeneration studies demonstrated that the adsorbent retained appreciable performance over multiple cycles, indicating its potential for reuse. These findings suggest that biochar-modified hydrogel beads provide a sustainable and effective approach for surfactant removal from wastewater.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Development of AVE-8063-Bearing Pt(IV) Prodrug for Dual-Action Light-Controlled Chemotherapy 双作用光控化疗用含ave -8063铂（IV）前药的研制

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-21 DOI: 10.1134/S1070363226601845

Daniil Spector, Anastasia Zharova, Georgy Karetnikov, Roman Akasov, Polina Demina, Yulia Isaeva, Tatiana Egorova, Elena Beloglazkina, Olga Krasnovskaya

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Extraction of REE(III), U(VI), and Th(IV) from Nitric Acid Solutions with Carbamoylmethylphosphine Oxides Bearing an Additional Phosphoryl Group 含磷基的氨甲酰甲基膦氧化物从硝酸溶液中萃取稀土（III）、铀（VI）和钍(IV

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-21 DOI: 10.1134/S107036322660164X

Alexander N. Turanov, Vasilii K. Karandashev, Vladimir A. Khvostikov, Elena V. Sharova, Oleg I. Artyushin, Kseniia V. Tcarkova, Natalia A. Bondarenko

{"title":"Extraction of REE(III), U(VI), and Th(IV) from Nitric Acid Solutions with Carbamoylmethylphosphine Oxides Bearing an Additional Phosphoryl Group","authors":"Alexander N. Turanov, Vasilii K. Karandashev, Vladimir A. Khvostikov, Elena V. Sharova, Oleg I. Artyushin, Kseniia V. Tcarkova, Natalia A. Bondarenko","doi":"10.1134/S107036322660164X","DOIUrl":"10.1134/S107036322660164X","url":null,"abstract":"The extraction of trace amounts of U(VI), Th(IV), and REE(III) from HNO3 solutions with new carbamoylmethylphosphine oxides Ph2P(O)CH2C(O)N(Bu)CH2P(O)Bu2 and Bu2P(O)CH2C(O)N(Bu)CH2P(O)Bu2, containing a phosphoryl group in the amide moiety of the molecule, in dichloroethane has been studied. The stoichiometry of the extracted complexes was determined, and the influence of the extractant structure and aqueous phase composition on the efficiency of U(VI), Th(IV), and REE(III) extraction into the organic phase was examined. It was shown that modification of diphenyl(dialkylcarbamoylmethyl)phosphine oxide by introducing an additional CH2P(O)Bu2 coordinating group via the amide nitrogen atom leads to an increase in the extraction efficiency of REE(III) ions from neutral nitrate solutions and a decrease in their extraction from nitric acid solutions. Replacement of phenyl substituents at the phosphorus atoms in the molecule of diphenyl(dibutylcarbamoylmethyl)phosphine oxide with butyl groups leads to an increase in the extraction efficiency of U(VI) and Th(IV) by the modified compounds from nitric acid solutions and a decrease in the recovery of REE(III) into the organic phase in the presence of an ionic liquid, 1-butyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149034545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Antimicrobial and Anti-inflammatory Activities of Quinoline Containing 2,5-Disubstituted 1,3,4-Oxadiazoles 含2,5-二取代1,3,4-恶二唑喹啉的抗菌和抗炎活性

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-18 DOI: 10.1134/S1070363225608725

Thejaswini P. Rai, Nefisath Pundikatte, K. Sharath Chandra, Jagadeesh Prasad Dasappa

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Bis-Phosphorylated 3-[5-(tert-Butyl)- and 5-(Adamantan-1-yl)fur-2-yl]acrylates in the Synthesis of Derivatives of Phosphorylated Unsaturated Dioxoacids and 4-Oxo-4H-pyrrolo[1,2-b]pyrazole-6-carboxylate 双磷酸化3-[5-（叔丁基）-和5-（金刚烷-1-基）-糠醛-2-基]丙烯酸酯在磷酸化不饱和二氧酸和4-氧- 4h -吡咯[1,2-b]吡唑-6-羧酸衍生物合成中的应用

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-18 DOI: 10.1134/S1070363226601833

Leonid M. Pevzner, Mikhail L. Petrov, Oleg V. Matusevich, Alexander V. Stepakov

{"title":"Bis-Phosphorylated 3-[5-(tert-Butyl)- and 5-(Adamantan-1-yl)fur-2-yl]acrylates in the Synthesis of Derivatives of Phosphorylated Unsaturated Dioxoacids and 4-Oxo-4H-pyrrolo[1,2-b]pyrazole-6-carboxylate","authors":"Leonid M. Pevzner, Mikhail L. Petrov, Oleg V. Matusevich, Alexander V. Stepakov","doi":"10.1134/S1070363226601833","DOIUrl":"10.1134/S1070363226601833","url":null,"abstract":"A series of 5-tert-butyl- and 5-(adamantan-1-yl)-(diethoxyphosphorylmethyl)-2-furoylphosphonates was synthesized. All the obtained bis-phosphonates were introduced into the Wittig reaction with ethoxycarbonylmethylenetriphenylphosphorane. It was found that tert-butyl derivatives, regardless of the position of the phosphonomethyl group, react under these conditions to give the corresponding 3-(furyl)acrylates. 5-(Adamantan-1-yl)-3-(diethoxyphosphorylmethyl)-2-furoylphosphonate does not react under these conditions, whereas its 4-(diethoxyphosphorylmethyl) isomer gives the expected product. Oxidation of the 3-(5-tert-butylfuryl)acrylate derivatives with bromine in the methylene chloride–aqueous sodium acetate system at 1–3°C leads in high yield to ethyl (2E,5Z)-3-(diethoxyphosphoryl)-(diethoxyphosphorylmethyl)-8,8-dimethyl-4,7-dioxonona-2,5-dienoate. In the case of the adamantyl analog, the diethoxyphosphorylmethyl group is oxidized first, and individual compounds were not isolated in this case. The synthesized esters of bis-phosphorylated unsaturated dioxo acids were introduced into the reaction with hydrazine hydrate in ethanol. The reaction products are oxidized on contact with atmospheric oxygen to form complex mixtures. Only in the case of the 6-diethoxyphosphorylmethyl derivative was the stable oxidation product, ethyl 2-tert-butyl-3-(diethoxyphosphorylmethyl)-4-oxo-4H-pyrrolo[1,2-b]pyrazole-6-carboxylate, isolated in 83% yield.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lysozyme-Based Microspherical Particles for Delivery of Nalidixic Acid: Preparation, Composition Optimization, and Solubility Study 以溶菌酶为基础的纳利地酸微球：制备、组成优化及溶解度研究

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-18 DOI: 10.1134/S1070363226603637

Alexander V. Gerasimov, Nikolay M. Lyadov, Alexander E. Klimovitskii, Elina R. Mirgazieva, Liana S. Zubaidullina

{"title":"Lysozyme-Based Microspherical Particles for Delivery of Nalidixic Acid: Preparation, Composition Optimization, and Solubility Study","authors":"Alexander V. Gerasimov, Nikolay M. Lyadov, Alexander E. Klimovitskii, Elina R. Mirgazieva, Liana S. Zubaidullina","doi":"10.1134/S1070363226603637","DOIUrl":"10.1134/S1070363226603637","url":null,"abstract":"The development of effective delivery systems for poorly soluble pharmaceuticals remains a critical challenge in modern pharmaceuticals. This study explores the use of lysozyme, a biopolymer with unique immunological and stabilizing properties, as a matrix for creating amorphous solid dispersions of nalidixic acid, a model hydrophobic antibiotic. By optimizing the composition using differential scanning calorimetry and X-ray powder diffractometry, a range of ratios of protein matrix and active pharmaceutical ingredient was determined in which amorphous solid dispersions are formed. Spray drying was used to produce microspherical particles suitable for inhalation therapy, resulting in particles predominantly 2–5 μm in size, suitable for alveolar deposition. This work demonstrates the potential of protein carriers such as lysozyme not only to enhance solubility and bioavailability but also to provide a synergistic therapeutic effect. The developed strategy for creating a dosage form is promising for improving the pulmonary delivery of other poorly water-soluble drugs while simultaneously reducing the required doses and minimizing side effects.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Supramolecular Catalytic Systems Based on Alkyltriphenylphosphonium Bromides and Polyethyleneimine 基于烷基三苯基溴化磷和聚乙烯亚胺的超分子催化体系

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-18 DOI: 10.1134/S1070363226603960

Gulnara A. Gaynanova, Guzaliya I. Kayupova, Leysan A. Vasileva

{"title":"Supramolecular Catalytic Systems Based on Alkyltriphenylphosphonium Bromides and Polyethyleneimine","authors":"Gulnara A. Gaynanova, Guzaliya I. Kayupova, Leysan A. Vasileva","doi":"10.1134/S1070363226603960","DOIUrl":"10.1134/S1070363226603960","url":null,"abstract":"The critical aggregation concentration values for aqueous binary systems of alkyltriphenylphosphonium bromides (TPPB-n) and polyethyleneimine (M = 50000 Da) were obtained by tensiometry and conductometry. In addition to the aggregation thresholds, the solubilization capacity of the mixed polymer–colloid aggregates toward the hydrophobic dye Orange OT was evaluated by spectrophotometry. It was established that the formation of mixed aggregates probably occurs only for the higher homologues of the phosphonium surfactants. The catalytic activity of the polymer–colloid aggregates was investigated in the hydrolysis of O-alkyl-O-(4-nitrophenyl)chloromethylphosphonates. The experimental dependences were analyzed within the framework of the pseudophase micellar catalysis model. For the more hydrophobic phosphonate, increasing the hydrocarbon tail length led to higher binding constants for both reagents and, consequently, to an increase in the factor of concentration. Analysis of the catalytic effect of the mixed TPPB-n–PEI system revealed a trend analogous to that observed for the aggregation behavior: the properties of the system depend on whether the surfactant belongs to the lower or higher members of the homologous series.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Visible-Light Photocatalyst CuO/SnO2/Ag: Synthesis, Performance Evaluation and Phytotoxicity Studies 可见光光催化剂CuO/SnO2/Ag的合成、性能评价及植物毒性研究

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-18 DOI: 10.1134/S1070363226602085

Anastasia A. Novikova, Viktoria E. Burlakova, Igor E. Uflyand, Elizaveta A. Mukhanova, Vladimir A. Irkha, Ekaterina G. Korzh

{"title":"Visible-Light Photocatalyst CuO/SnO2/Ag: Synthesis, Performance Evaluation and Phytotoxicity Studies","authors":"Anastasia A. Novikova, Viktoria E. Burlakova, Igor E. Uflyand, Elizaveta A. Mukhanova, Vladimir A. Irkha, Ekaterina G. Korzh","doi":"10.1134/S1070363226602085","DOIUrl":"10.1134/S1070363226602085","url":null,"abstract":"Nanocomposite photocatalysts are promising for removing pollutants from wastewater. Despite intensive studies, less attention is paid to toxicity of nanocomposites. In our work, we have obtained a new hetero-photocatalyst based on nanostructured CuO (1.5 μm), decorated with Ag (100 nm) and low crystallinity SnO2. The composition and morphology were studied by XRD, SEM, EDX and AFM. The photocatalytic decomposition of the methyl orange under natural sunlight was investigated. About 84% of the dye decomposed in 120 min, in contrast to unmodified CuO (only 50%). The mechanism of photocatalysis is proposed. The degradation process corresponded to the pseudo-first order kinetics. A decrease in the optical band gap of the nanocomposite compared to unmodified CuO was noted. The nanocomposite efficiency associated with the surface increasing and the heterojunction formation. The phytotoxic effect on the aquatic plant Ceratophyllum demersum was studied. A decrease in phytotoxicity in contrast to the initial CuO was established. The nanocomposite provided a stimulating effect on the chlorophyll a concentration. The results expand the knowledge about the phytotoxicity of photocatalytic nanocomposites.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148986918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0