N. Z. Hakobyan, M. S. Safaryan, A. S. Grigoryan, Zh. R. Alaverdyan, R. G. Paronikyan, L. S. Mirzoyan, H. V. Gasparyan, Н. A. Panosyan, A. A. Harutyunyan
{"title":"Search for Monoamine Oxidase Inhibitors among 4-Aryl-6-(4-alkoxyphenyl)-2-arylpyrimidines. Study of Anticonvulsant and Psychotropic Activities","authors":"N. Z. Hakobyan, M. S. Safaryan, A. S. Grigoryan, Zh. R. Alaverdyan, R. G. Paronikyan, L. S. Mirzoyan, H. V. Gasparyan, Н. A. Panosyan, A. A. Harutyunyan","doi":"10.1134/S1070363225600213","DOIUrl":"10.1134/S1070363225600213","url":null,"abstract":"<p>Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2<i>E</i>)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with the substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The antimonoamine oxidase, anticonvulsant and psychotropic properties of the resulting systems were studied.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"927 - 934"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catalytic Transfer Hydrogenation of Furfural to Furfuryl Alcohol over Hydrotalcite Derived Mg2Al1–xFexO: Role of Surface Basicity","authors":"H. Lin, P. Xiao, W. Gan, K. Qi, S. Wang, J. Zhu","doi":"10.1134/S1070363225600298","DOIUrl":"10.1134/S1070363225600298","url":null,"abstract":"<p>Hydrotalcite-derived MgAl oxides, known for their acid-base bifunctional properties, have gained substantial interest as catalysts in heterogeneous reactions. In this study, we synthesized Mg<sub>2</sub>Al<sub>1–<i>x</i></sub>Fe<sub><i>x</i></sub>O catalysts by thermally decomposing layered double hydroxides (Mg<sub>2</sub>Al<sub>1–<i>x</i></sub>Fe<sub><i>x</i></sub>–LDH) at 400°C. The results showed that the Fe substitution reduced the acidity, while enhancing the basicity, of Mg<sub>2</sub>Al<sub>1–<i>x</i></sub>Fe<sub><i>x</i></sub>O, providing a way to adjust the acidity and basicity of materials for specific reactions. Catalytic transfer hydrogenation (CTH) of furfural to furfuryl alcohol, with isopropanol as hydrogen donor, was applied to evaluate the catalytic performances of Mg<sub>2</sub>Al<sub>1–<i>x</i></sub>Fe<sub><i>x</i></sub>O. Mg<sub>2</sub>AlO, Mg<sub>2</sub>Al<sub>0.8</sub>Fe<sub>0.2</sub>O and Mg<sub>2</sub>Al<sub>0.5</sub>Fe<sub>0.5</sub>O exhibit comparable catalytic hydrogenation activities, despite the progressive decrease in surface acidity and the corresponding increase in basicity. To elucidate the contributions of acid and base sites to the CTH process, poisoning experiments were carried out to passivate them by adding pyridine or benzoic acid to the reaction, which suggests that the evolution occurring on the base site is the rate-determining step of the reaction. Effect of reaction conditions on the activity of Mg<sub>2</sub>Al<sub>0.5</sub>Fe<sub>0.5</sub>O were investigated, and a reaction mechanism was proposed, to reveal the reaction nature.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"935 - 948"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Antibacterial Activity of Novel 1,2,3-Triazole Pendant 2-Styrylchromone Derivatives","authors":"P. Limbadri, Y. Hemasri, Y. Jayaprakash Rao","doi":"10.1134/S1070363224610810","DOIUrl":"10.1134/S1070363224610810","url":null,"abstract":"<p>A new series of 1,2,3-triazole tethered 2-styrylchromone derivatives were synthesized by adopting a simple and efficient regioselective Cu(I) catalyzed 1,3-dipolar cycloaddition reaction of corresponding 3-<i>O</i>-propargyl 2-styrylchromone with various aryl azides. The synthesized compounds were characterized using <sup>1</sup>H, <sup>13</sup>C NMR, HRMS and mass spectrometry and were screened for their antibacterial activity. Two representatives of synthesized dihalogen-substituted compounds showed good activity.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"824 - 832"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Spectral–Luminescent Properties of 2-Amino-6-chloro-4-(4-(dimethylamino)phenyl)pyridine-3,5-dicarbonitrile and Compounds Based on It","authors":"I. N. Bardasov, A. U. Alekseeva, M. Yu. Ievlev","doi":"10.1134/S1070363225601127","DOIUrl":"10.1134/S1070363225601127","url":null,"abstract":"<p>A series of new donor–acceptor chromophores based on pyridine derivatives was synthesized by substituting the chlorine atom in 2-amino-4-(4-(dimethylamino)phenyl)-6-chloropyridine-3,5-dicarbonitrile with a variety of <i>N</i>-, <i>C</i>-, <i>O</i>-, and <i>S</i>-nucleophiles. The spectral and luminescent properties of the resulting compounds in DMSO were examined. The absorption spectra featured intense bands with maxima in the range of 345–380 nm. In the case of compounds bearing an exocyclic double bond, pronounced shoulders were observed in the longer-wavelength region, extending up to 400 nm. Quantum chemical calculations based on density functional theory (DFT) made it possible to assign the observed absorption bands to specific electronic transitions and to attribute the appearance of shoulders to the presence of multiple tautomeric forms of the chromophores in solution. All synthesized compounds displayed photoluminescence with emission maxima in the range of 467–546 nm, depending on the nature of the introduced nucleophile.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"980 - 989"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Triazole Functionalized Quinazolinone Derivatives, Their Anticancer Activity, and Docking Interactions","authors":"B. Udayasri, P. Naveen, B. Sailu","doi":"10.1134/S1070363224612729","DOIUrl":"10.1134/S1070363224612729","url":null,"abstract":"<p>A series of novel triazole functionalized quinazolinone derivatives were synthesized starting from 2-amino-6-(trifluoromethyl)benzonitrile. All the final compounds were evaluated for anticancer activity against four human cancer cell lines such as HeLa—cervical cancer (CCL-2), COLO 205—colon cancer (CCL-222), HepG2—liver cancer (HB-8065), MCF7—breast cancer (HTB-22), and promising compounds have been identified. Two compounds were further evaluated for molecular docking interactions.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"864 - 872"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Wang, Z. Gu, X. Chen, D. Cai, A. Zhang, X. Niu, Y. Zhou, X. Weng, H. Lu
{"title":"Highly Efficient Purification of Styrene Exhaust Gas by Aqueous Oxidation-Absorption and Kinetic Study","authors":"W. Wang, Z. Gu, X. Chen, D. Cai, A. Zhang, X. Niu, Y. Zhou, X. Weng, H. Lu","doi":"10.1134/S107036322560047X","DOIUrl":"10.1134/S107036322560047X","url":null,"abstract":"<p>Organic solvents (e. g., mineral oil) are frequently employed as absorbents to purify VOCs, but their absorption efficiency and saturation capacity are limited and the high viscosity causes uneven liquid distribution and increased pressure drop, restricting their industrial applications. To surmount these limitations, this work develops the use of water as an absorbent combined with aqueous-phase chemical oxidation absorption to remove low-concentration styrene from exhaust gases. The effects of key parameters, including oxidant type, styrene concentration, and liquid-phase pH on the oxidation absorption performance were systematically investigated. Experimental results indicate that KMnO<sub>4</sub> outperforms K<sub>2</sub>FeO<sub>4</sub> and NaClO<sub>2</sub> in enhancing styrene absorption, KMnO<sub>4</sub> can interact with the C=C bonds in styrene to form cyclic permanganate ester intermediate with a lower activation energy, thereby facilitating the oxidation process. Under the oxidation action of KMnO<sub>4</sub>, styrene is rapidly oxidized into water-soluble species, primarily benzaldehyde, significantly improving the absorption ability of water for styrene, with a purification efficiency exceeding 95%. In weakly alkaline conditions of pH 9, the saturation absorption capacity of KMnO<sub>4</sub> for styrene reaches 308.6 mg/g. A detailed reaction pathway for the KMnO<sub>4</sub>-mediated oxidation of styrene under various pH conditions is proposed and further validated through quantum chemical calculations. Additionally, kinetic studies reveal that the oxidation of styrene by KMnO<sub>4</sub> follows a second-order reaction model, with an apparent activation energy of 15.205 kJ/mol. These findings provide valuable insights into the development of efficient VOCs purification technologies for industrial applications.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"958 - 968"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jurang Li, Zhizhuo Qu, Zhiqiang Cai, Chunmeng Li, Yang Liu, Yingnuo Wang, Weidong Zhang, Lekun Wei, Hongying Ji
{"title":"Design, Synthesis, and Biological Activity Study of Antitumor Drugs Containing Aryl Hydrazone Quinazoline","authors":"Jurang Li, Zhizhuo Qu, Zhiqiang Cai, Chunmeng Li, Yang Liu, Yingnuo Wang, Weidong Zhang, Lekun Wei, Hongying Ji","doi":"10.1134/S1070363224612195","DOIUrl":"10.1134/S1070363224612195","url":null,"abstract":"<p>A series of novel quinazoline derivatives containing aromatic hydrazones were synthesized and characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, MS, and IR. The antitumor activity of the compounds was tested using A549 and MKN45 cell lines with gefitinib and foretinib as positive control drugs. By combining its unique molecular docking model, the target derivatives were docked with proteins to explore the binding mode and biological activity of the target derivatives on the EGFR/c-Met dual target, and the ADME data of the compounds were ultimately predicted. The final proof shown that (<i>E</i>)-4-[3-({4-[2-(3-chlorobenzylidene)hydrazineyl]-7-methoxyquinazolin-6-yl}oxy)propyl]morpholine and (<i>E</i>)-4-[3-({4-[2-(2,4-dichlorobenzylidene)hydrazineyl]-7-methoxyquinazolin-6-yl}oxy)propyl]morpholine have high drug-like properties and further research value.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"851 - 863"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu. S. Galimova, O. Yu. Kupova, Sh. M. Salikhov, L. Kh. Faizullina
{"title":"Approaches to the Synthesis of Acetogenins Based on the Michael Adducts of Levoglucosenone and α-Carboethoxycyclododecanone and Analysis of Their Biological Activity","authors":"Yu. S. Galimova, O. Yu. Kupova, Sh. M. Salikhov, L. Kh. Faizullina","doi":"10.1134/S1070363225600602","DOIUrl":"10.1134/S1070363225600602","url":null,"abstract":"<p>A short synthesis of a chiral functionally substituted γ-lactone, a structural analogue of acetogenins, was carried out on the basis of diastereomeric Michael adducts of levoglucosenone and α-carboethoxycyclododecanone. Molecular docking of levoglucosenone derivatives was performed. It was shown that the synthesized γ-lactone is capable of binding to tubulin, which indicates its possible antitumor activity.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"815 - 823"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Yu. Vdovina, R. R. Galimullin, E. M. Zakharova, S. V. Kolesov
{"title":"Thermo- and Photo-Oxidative Stability of Poly(methyl methacrylate) and Polystyrene Obtained in Presence of Some Metal Complexes","authors":"O. Yu. Vdovina, R. R. Galimullin, E. M. Zakharova, S. V. Kolesov","doi":"10.1134/S1070363224613139","DOIUrl":"10.1134/S1070363224613139","url":null,"abstract":"<p>This research was carry out to evaluate the thermo-oxidative and photo-oxidative stability of industrially important vinyl polymers poly(methyl methacrylate) and polystyrene obtained by radical-initiated polymerization in the presence of some metal complexes. Under conditions characteristical of practical polymer operation, the thermal oxidative stability of PMMA obtained on ferrocene, titanocene dichloride and zirconocene dichloride increases by 27–49°C. PMMA and PS obtained by free-radical polymerization, and PMMA(FC), PMMA(TC), PMMA(ZC), PS(TC) may be characterized as relatively resistant to photo-ageing.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"999 - 1005"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sakthivel, R. Antony, J. Amala Ebi Jacob, J. Dhaveethu Raja
{"title":"Methods for CO2 Mitigation and Role of Biochar (A Review)","authors":"A. Sakthivel, R. Antony, J. Amala Ebi Jacob, J. Dhaveethu Raja","doi":"10.1134/S1070363225600511","DOIUrl":"10.1134/S1070363225600511","url":null,"abstract":"<p>Carbon dioxide utilization is an excellent strategy to control the rising concentration of carbon dioxide in the atmosphere. Its success relies on the effectiveness of carbon dioxide capturing and separation from emission points. Coal and natural gas-firing thermal power plants are the major causes of carbon dioxide emissions. This emphasizes the importance of techniques that effectively capture carbon dioxide from thermal power plants. Following capture, the separation of carbon dioxide from the flue gas mixture is also important to achieve ultrapure carbon dioxide suitable for chemical synthesis. Therefore, this minireview presents the techniques available for carbon dioxide capturing and separation. Also, the utilization methods of carbon dioxide are briefly outlined along with their merits and demerits. Special emphasis is given to the role of biochar materials in separating carbon dioxide from flue gas. We believe that this review will give an overview of carbon dioxide capturing, separation, and utilization methods.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 4","pages":"783 - 799"},"PeriodicalIF":0.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}