Russian Journal of General Chemistry最新文献_第4页

Indole-Functionalized Heterocyclic Molecules: Synthesis and Related Applications (A Review) 吲哚功能化杂环分子的合成及其应用综述

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-13 DOI: 10.1134/S1070363225607124

Ranvir Kumar, Dhananjay Kumar Sharma, Prem lata, Budhdeo Gautam, Shachi Mishra, Rajesh kumar, Navedul Haque

{"title":"Indole-Functionalized Heterocyclic Molecules: Synthesis and Related Applications (A Review)","authors":"Ranvir Kumar, Dhananjay Kumar Sharma, Prem lata, Budhdeo Gautam, Shachi Mishra, Rajesh kumar, Navedul Haque","doi":"10.1134/S1070363225607124","DOIUrl":"10.1134/S1070363225607124","url":null,"abstract":"Indole heterocycles are one of the most significant scaffolds in biological systems such as neurotransmitter, enzyme inhibition, coordination chemistry, drug discovery, and organic synthesis. It plays an important role in cell biology, and the utility of indole and its derivatives for the treatment of cancer cells, various kinds of disorders in the human body, and microbes has attracted insightful attention in past decades. Several FDA-approved drugs based on indole scaffolds such as frovatriptan, zolmitriptan, almotriptan, melatonin etc. for the treatment of nervous system are running in the market as well as several indole-based scaffolds are under clinical trial in different phases. Due to the significance of the indole scaffold, the study of novel approaches for the preparation has drawn the attention of the chemical community. This review primarily focused on the classical and modern synthetic methodology of indole and its derivatives, their mechanisms, biological and other applications, such as chemo-sensors, fluorescence probes, etc.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermolecular Non-Covalent Interactions in the Crystal Packing of Spirobarbiturates: A Hirshfeld Surface Analysis 螺旋巴比妥酸盐晶体填充中的分子间非共价相互作用：赫希菲尔德表面分析

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-13 DOI: 10.1134/S1070363226602127

Arthur A. Puzyrkov, Daria A. Zykova, Ekaterina V. Berezhnaya, Kristina A. Kim, Vitaly M. Boitsov, Alexander V. Stepakov

引用次数: 0

Full Factorial Analysis of Variance Technique for Catalytic Reduction of 4-Nitrophenol Using rGO-CuO under Aqueous System with Kinetic Studies rGO-CuO水溶液催化还原4-硝基苯酚的全因子方差分析及动力学研究

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-13 DOI: 10.1134/S107036322560362X

Gayatri Pandey, Jagdish Prasad, Narendra Pal Lamba, Manmohan Singh Chauhan

引用次数: 0

In Silico Design and Green Synthesis of Polyhydroxy Conjugated Piperidine and Pyrrolidine Derivatives for In vitro Antiglycation Activity 多羟基共轭哌啶和吡咯烷衍生物的体外抗糖化活性的硅设计和绿色合成

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-13 DOI: 10.1134/S1070363225608130

Anju Daharia, Alok Singh Thakur, Lokkanya Dewangan

{"title":"In Silico Design and Green Synthesis of Polyhydroxy Conjugated Piperidine and Pyrrolidine Derivatives for In vitro Antiglycation Activity","authors":"Anju Daharia, Alok Singh Thakur, Lokkanya Dewangan","doi":"10.1134/S1070363225608130","DOIUrl":"10.1134/S1070363225608130","url":null,"abstract":"The research work focuses on the design and development of a novel series of polyhydroxy-conjugated piperidine and pyrrolidine derivatives via microwave-assisted green synthesis, achieving high yields (82–87%) while providing a sustainable, energy-efficient alternative to conventional approaches. Physicochemical and spectroscopic techniques comprehensively characterized the synthesized derivatives. Their inhibitory activity against α-amylase, α-glucosidase, and advanced glycation end products formation was assessed through in vitro assays. Among the synthesized derivatives, 2,3,4,5,6-Pentahydroxyhexyl [3-phenyl-3-(p-tolylimino)propyl]prolinate exhibited dual inhibition of α-amylase (IC50 = 23.67 ± 0.91 µM) and α-glucosidase (IC50 = 38.08 ± 0.57 µM), surpassing that of rutin. In antiglycation assays, the most active synthesized derivatives significantly reduced the formation of AGEs by reducing fructosamine level, protein carbonylation, thiol oxidation, and congo red binding. The structure-activity relationship (SAR) analysis indicated that the electron-donating substituents significantly enhanced biological activity. Further, molecular docking simulations validated the binding interactions with human serum albumin (PDB ID: 4IW1) and supported the mechanistic insights into their mode of action. Notably, pyrrolidine derivatives demonstrated superior efficacy compared to their piperidines, attributed to their enhanced conformational flexibility and synergistic polyhydroxy interactions, facilitated hydrogen bonding, metal chelation, and nucleophilic reactivity toward carbonyl species. Overall, these findings highlight green-synthesized polyhydroxy-conjugated piperidine and pyrrolidine derivatives, particularly this compound, as promising scaffolds for antiglycation therapy and modulation of diabetes-associated complications.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Approaches to the Synthesis of 6-Amino-4-aryl-5-(4-arylthiazol-2-yl)-2-methoxynicotinonitriles 合成6-氨基-4-芳基-5-（4-芳基噻唑-2-基）-2-甲氧基烟腈的新方法

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-13 DOI: 10.1134/S1070363226601766

Nikolay A. Pakholka, Andrey V. Churakov, Denis V. Nikitenko, Sergey G. Krivokolysko

引用次数: 0

Synthesis, Crystal Structure, DFT, MEP, FMOs, Hirshfeld Analysis and Antitumor Activity Assay of 4-[(4-Fluorophenyl)amino]-6-pentylpyrido[4,3-d]pyrimidin-5(6H)-one 4-[（4-氟苯基）氨基]-6-戊基吡啶[4,3-d]嘧啶-5(6H)- 1的合成、晶体结构、DFT、MEP、FMOs、Hirshfeld分析和抗肿瘤活性测定

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-13 DOI: 10.1134/S1070363226601535

Wei Zeng, Run-Tao Guo, Lan Jin, Jun-Tong Ren, Wen-Fang Deng, Xin-Lian Wen, Zhi-Xu Zhou, Chun Ji, Hui-Fang Chai

{"title":"Synthesis, Crystal Structure, DFT, MEP, FMOs, Hirshfeld Analysis and Antitumor Activity Assay of 4-[(4-Fluorophenyl)amino]-6-pentylpyrido[4,3-d]pyrimidin-5(6H)-one","authors":"Wei Zeng, Run-Tao Guo, Lan Jin, Jun-Tong Ren, Wen-Fang Deng, Xin-Lian Wen, Zhi-Xu Zhou, Chun Ji, Hui-Fang Chai","doi":"10.1134/S1070363226601535","DOIUrl":"10.1134/S1070363226601535","url":null,"abstract":"Pyrido[4,3-d]pyrimidine derivatives represent an important class of heterocyclic compounds that play an indispensable role in organic synthetic chemistry and drug discovery. As homologues of pyrimidine antagonists, the pyrido[4,3-d]pyrimidine scaffold holds significant theoretical value and application potential in biochemical research and clinical settings such as tumor chemotherapy. In the present study, the target compound 4-[(4-fluorophenyl)amino]-6-pentylpyrido[4,3-d]pyrimidin-5(6H)-one was synthesized via multi-step organic reactions using malononitrile as the starting material, with its synthetic route encompassing key steps including addition, cyclization, substitution, and Suzuki coupling. Four spectroscopic characterization techniques were utilized to systematically confirm the chemical structure of the target compound. Additionally, its crystal structure was unambiguously determined by X-ray single-crystal diffraction analysis, while the optimized molecular structure was obtained through density functional theory (DFT) calculations. The results demonstrated that the DFT-optimized molecular structure is in good agreement with the crystal structure measured by X-ray single-crystal diffraction, thereby validating the reliability of the theoretical calculations. Furthermore, systematic property investigations were conducted on the target compound, including infrared characteristic vibration analysis, molecular electrostatic potential (MEP) distribution, frontier molecular orbitals (FMOs) analysis, Hirshfeld surface analysis, and in vitro antitumor activity evaluation. These findings provide a robust experimental and theoretical foundation for the further structural modification and pharmacological research of this class of pyrido[4,3-d]pyrimidine derivatives.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 10","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Photophysical Properties of 4-Aroyl-2,6-diaminopyridine-3,5-dicarbonitriles 4-芳基-2,6-二氨基吡啶-3,5-二碳腈的合成及其光物理性质

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-13 DOI: 10.1134/S1070363226601754

Oleg V. Ershov, Yakov S. Kayukov, Olga V. Kayukova, Oleg E. Nasakin

引用次数: 0

Preparation of Cellulose Granules Modified with Carbon Nanotubes for Enhanced Adsorption of Cu(II) Ions 碳纳米管改性纤维素颗粒对Cu（II）离子吸附性能的研究

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070363226160127

D. A. Vokurova, T. E. Nikiforova

{"title":"Preparation of Cellulose Granules Modified with Carbon Nanotubes for Enhanced Adsorption of Cu(II) Ions","authors":"D. A. Vokurova, T. E. Nikiforova","doi":"10.1134/S1070363226160127","DOIUrl":"10.1134/S1070363226160127","url":null,"abstract":"vative sorbent for removing copper(II) ions from water was developed as a composite material based on cellulose and carbon nanotubes. First, a granular sorbent was prepared by dissolving preliminarily ground cotton cellulose fibers in an aqueous alkaline urea solution at –12.5°C, followed by crosslinking with epichlorohydrin and dropwise addition of the resulting transparent cellulose solution to a 12% sodium chloride solution to obtain the initial cellulose granules. The cellulose granules were then modified sequentially by treatment with a dopamine solution and oxidized carbon nanotubes dissolved in toluene. Cellulose granules modified with carbon nanotubes were thus obtained. The kinetics and equilibrium of Cu2+ ion sorption by the initial cellulose granules and cellulose granules modified with carbon nanotubes were then studied. The time required to reach sorption equilibrium in the heterogeneous system comprising an aqueous copper sulfate solution and the sorbent was determined in a kinetic experiment. The kinetic curves of copper ion sorption by the initial cellulose granules and cellulose granules modified with carbon nanotubes were processed using pseudo-first-order and pseudo-second-order kinetic models and the Weber–Morris diffusion model. The experimental isotherms of copper(II) ion sorption by the initial and modified sorbents were processed using the Langmuir, Freundlich, Dubinin–Radushkevich, and Temkin models. The data obtained by processing the isotherms of copper ion sorption from aqueous CuSO4 solutions using different models were compared. The maximum sorption capacities (A∞) of the obtained samples for Cu2+ ions were determined. According to the Langmuir model, A∞ of the modified cellulose sorbent was seven times higher than that of the initial cellulose granules.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Form-Stable Hydrogel Carriers Based on Chitosan and Sodium Alginate for Sustained Drug Release 壳聚糖和海藻酸钠形成稳定的水凝胶缓释载体

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070363226160103

I. M. Lipatova, A. A. Yusova, L. I. Makarova

{"title":"Form-Stable Hydrogel Carriers Based on Chitosan and Sodium Alginate for Sustained Drug Release","authors":"I. M. Lipatova, A. A. Yusova, L. I. Makarova","doi":"10.1134/S1070363226160103","DOIUrl":"10.1134/S1070363226160103","url":null,"abstract":"The possibility of obtaining hybrid hydrogels based on sodium alginate and chitosan that acquire form stability through interpolyelectrolyte complex formation was studied. The advantages of such hydrogels include the absence of chemical crosslinking agents, the combination of beneficial physiological properties, and the possibility of controlling the release rate of incorporated drugs by varying the ratio of the polymer components. Hybrid hydrogels were prepared by mixing 2% aqueous solutions of the polysaccharides. Conventional mixing produces a lumpy mass that cannot be molded. Mechanical treatment of the mixture of polysaccharide solutions in a rotor-pulsation apparatus for 4 s produced a hydrogel mass capable of assuming a specified shape after being held in special cells. The ability of the mixtures to form physical hydrogels was studied by rheological measurements and by measuring the physicomechanical properties of tablet-shaped samples using three compositions with chitosan : alginate molar ratios of 1 : 2, 1 : 1, and 2 : 1. Hydrogels with an equimolar ratio of the polyelectrolytes in the mixture were found to have the highest consistency coefficient and, accordingly, the lowest flow behavior index, as well as the highest uniaxial compressive strength. The highest resistance to syneresis was obtained at a chitosan : alginate ratio of 1 : 2. The cationic dye methylene blue and the anionic dye Reactive Brilliant Red 5CX were used as model compounds to evaluate the effect of the polyelectrolyte ratio in the hydrogels on the release rate of ionic drugs. The release rate of a model compound was found to decrease with an increase in the proportion of the oppositely charged polyelectrolyte in the polymer matrix.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Properties of Polymer–Colloid Dispersions Based on Colloidal Magnesium Hydroxide Particles Stabilized with Poly-N-vinylpyrrolidone 聚n -乙烯基吡咯烷酮稳定氢氧化镁胶体粒子的制备及性能研究

IF 1 4区化学

Russian Journal of General Chemistry Pub Date : 2026-09-07 DOI: 10.1134/S1070363226160048

M. V. Bazunova, V. V. Kaleeva

{"title":"Preparation and Properties of Polymer–Colloid Dispersions Based on Colloidal Magnesium Hydroxide Particles Stabilized with Poly-N-vinylpyrrolidone","authors":"M. V. Bazunova, V. V. Kaleeva","doi":"10.1134/S1070363226160048","DOIUrl":"10.1134/S1070363226160048","url":null,"abstract":"This work focuses on the possibility of stabilizing negatively and positively charged micelles of a magnesium hydroxide sol with the water-soluble synthetic physiologically active polymer poly-N-vinylpyrrolidone and on the rheological behavior of the resulting polymer–colloid dispersions. The time during which a polymer–colloid dispersion remains stable should be comparable to the time required to form a material based on it. Therefore, the most important task is to maintain the stability of lyophobic sols during the preparation of materials based on them, for example, through polymer stabilization. This determines the relevance of the present work. Turbidimetric studies showed that mixing poly-N-vinylpyrrolidone solutions with a magnesium hydroxide sol containing either negatively or positively charged colloidal particles results in the formation of polymer–colloid complexes at virtually any ratio of the initial components. The maximum complexation effect is observed at a polymer solution-to-sol volume ratio of 1 : 1. Importantly, polyvinylpyrrolidone stabilizes the micelles of the lyophobic magnesium hydroxide sol, since the presence of polymer macromolecules in the sol unequivocally increases its aggregative stability. Stabilization occurs mainly through specific adsorption and possibly hydrophobic interactions, as well as weak electrostatic or donor–acceptor interactions between the polymer and the micelles. When positively charged colloidal particles of the magnesium hydroxide sol are used, self-organization of the polymer–inorganic system with the formation of topological entanglement network junctions occurs to a greater extent than when negatively charged colloidal particles are used. This opens up possibilities for controlling the physicomechanical properties of polymeric materials produced from the polymer–colloid dispersions studied.","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148927026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0