Search for Monoamine Oxidase Inhibitors among 4-Aryl-6-(4-alkoxyphenyl)-2-arylpyrimidines. Study of Anticonvulsant and Psychotropic Activities

Abstract

Condensation of 1-(4-alkoxyphenyl)ethanones with aromatic aldehydes in the presence of sodium hydroxide in an aqueous-ethanol solution yielded (2E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with the substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The antimonoamine oxidase, anticonvulsant and psychotropic properties of the resulting systems were studied.