Approaches to the Synthesis of Acetogenins Based on the Michael Adducts of Levoglucosenone and α-Carboethoxycyclododecanone and Analysis of Their Biological Activity

Abstract

A short synthesis of a chiral functionally substituted γ-lactone, a structural analogue of acetogenins, was carried out on the basis of diastereomeric Michael adducts of levoglucosenone and α-carboethoxycyclododecanone. Molecular docking of levoglucosenone derivatives was performed. It was shown that the synthesized γ-lactone is capable of binding to tubulin, which indicates its possible antitumor activity.