Synthesis and Antibacterial Activity of Novel 1,2,3-Triazole Pendant 2-Styrylchromone Derivatives

Abstract

A new series of 1,2,3-triazole tethered 2-styrylchromone derivatives were synthesized by adopting a simple and efficient regioselective Cu(I) catalyzed 1,3-dipolar cycloaddition reaction of corresponding 3-O-propargyl 2-styrylchromone with various aryl azides. The synthesized compounds were characterized using ¹H, ¹³C NMR, HRMS and mass spectrometry and were screened for their antibacterial activity. Two representatives of synthesized dihalogen-substituted compounds showed good activity.