Novel Triazole Functionalized Quinazolinone Derivatives, Their Anticancer Activity, and Docking Interactions

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-04-25 DOI:10.1134/S1070363224612729

B. Udayasri, P. Naveen, B. Sailu

引用次数: 0

Abstract

A series of novel triazole functionalized quinazolinone derivatives were synthesized starting from 2-amino-6-(trifluoromethyl)benzonitrile. All the final compounds were evaluated for anticancer activity against four human cancer cell lines such as HeLa—cervical cancer (CCL-2), COLO 205—colon cancer (CCL-222), HepG2—liver cancer (HB-8065), MCF7—breast cancer (HTB-22), and promising compounds have been identified. Two compounds were further evaluated for molecular docking interactions.

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新型三唑功能化喹唑啉酮衍生物及其抗癌活性和对接作用

以2-氨基-6-（三氟甲基）苯并腈为起始原料，合成了一系列新的三唑功能化喹唑啉酮衍生物。所有化合物对hela -宫颈癌（CCL-2）、COLO 205 -结肠癌（CCL-222）、hepg2 -肝癌（HB-8065）、mcf7 -乳腺癌（HTB-22）等4种人类癌细胞系的抗肿瘤活性进行了评价，并发现了有潜力的化合物。进一步评估了两种化合物的分子对接相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.