左旋葡萄糖酮和α-碳乙氧基环十二酮Michael加合物合成醋酸原素的方法及生物活性分析

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-04-25 DOI:10.1134/S1070363225600602

Yu. S. Galimova, O. Yu. Kupova, Sh. M. Salikhov, L. Kh. Faizullina

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引用次数: 0

摘要

以左旋葡萄糖酮和α-碳乙氧基环十二酮的非对映体Michael加合物为基础，合成了手性取代γ-内酯。左旋葡萄糖酮衍生物的分子对接。结果表明，合成的γ-内酯能与微管蛋白结合，提示其可能具有抗肿瘤活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Approaches to the Synthesis of Acetogenins Based on the Michael Adducts of Levoglucosenone and α-Carboethoxycyclododecanone and Analysis of Their Biological Activity

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Approaches to the Synthesis of Acetogenins Based on the Michael Adducts of Levoglucosenone and α-Carboethoxycyclododecanone and Analysis of Their Biological Activity

A short synthesis of a chiral functionally substituted γ-lactone, a structural analogue of acetogenins, was carried out on the basis of diastereomeric Michael adducts of levoglucosenone and α-carboethoxycyclododecanone. Molecular docking of levoglucosenone derivatives was performed. It was shown that the synthesized γ-lactone is capable of binding to tubulin, which indicates its possible antitumor activity.

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.