Synthesis of Potentially Biologically Active Pyrazole Derivatives of Ricinoleic Acid

Abstract

An effective approach was developed for the synthesis of a number of pyrazole derivatives of ricinoleic acid, available from natural castor oil. Transesterification of the ricinoleic acid triglyceride to its methyl ester, oxidation to a keto derivative, and acid isomerization resulted in a single α,β-unsaturated ketone of the E-configuration, whose reaction with a number of hydrazides completed the synthesis.