Design, Synthesis of Naphthyridine-Integrated Pyranopolyheterocycle Derivatives and Their Biological Activities

Abstract

This study efforts on the synthesis of 1,5-naphthyridine derivatives and their biological activities. The structural characterization of the newly synthesized compounds was determined employing spectral data, including IR, NMR (¹H and ¹³C), mass spectrometry, and elemental analysis. The SAR investigation, specifically with methoxy-substituted derivatives, exhibited notable antioxidant activity, nitro-substituted derivatives had discriminative anticancer activity against all cell lines, and chloro-substituted compounds had promising anti-tubercular activity. This study demonstrates that scaffold structures and variations of moieties can influence biological activity. Consequently, pyrano[2,3-b]pyridine-6-cabonitrile series represent acceptable drug candidates for further in vivo drug development, as they represent drug candidates for cancer and tuberculosis.