New Derivatives of Coumarin-3-carboxylic Acid Containing a Furopyridine Fragment: Synthesis and Some Properties

Abstract

As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.