{"title":"Synthesis and Biological Activities of N-(2-Acetoxybenzoyl)amino Acid Esters","authors":"Guanyu Wang, Zhonglan Wei, Di Lin, Zihao Wu, Lianxuan Chen, Zilong Tang","doi":"10.1134/S1070363226601924","DOIUrl":"10.1134/S1070363226601924","url":null,"abstract":"<p>In this study, a series of <i>N</i>-(2-acetoxybenzoyl)amino acid esters were synthesized. The title compounds were assessed for both their antifungal activities against six phytopathogenic fungi and their anti-proliferative activity against HCCLM3 and MCF-7 cell lines. The results demonstrated that these compounds possessed modest yet definite antifungal activity against the selected phytopathogens. Notably, methyl <i>N</i>-(2-acetoxybenzoyl)tryptophanate exhibited significant dual functionality, achieving 88.9% inhibition against <i>S. sclerotiorum</i> and showing the most potent anti-proliferative activity against HCCLM3 cells, with an IC<sub>50</sub> value of 7.37 μM.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Green Synthesis of Reduced Graphene Oxide Using Neem (Azadirachta indica) Leaf Extract for Efficient Removal of Heavy Metals and Dyes from Industrial Wastewater","authors":"Deepak Kumar Rai, Shivansh Tripathi, Shiva Kant Ojha, Kumari Pooja, Mridula Tripathi","doi":"10.1134/S1070363226601134","DOIUrl":"10.1134/S1070363226601134","url":null,"abstract":"<p>Reduced graphene oxide (rGO) was synthesized via an eco-friendly green route using <i>Azadirachta indica</i> (neem) leaf extract as a natural reducing and stabilizing agent. Graphene oxide (GO) was first prepared using a modified Hummers’ method and subsequently reduced through the action of phytochemicals present in the neem extract, thereby eliminating the need for hazardous chemical reductants. Structural and morphological characterization using XRD, FTIR, Raman spectroscopy, and SEM confirmed the effective reduction of GO, partial restoration of the <i>sp</i><sup>2</sup>-carbon network, and the formation of wrinkled, porous rGO structures suitable for adsorption applications. The adsorption performance of the green-synthesized rGO was evaluated using real industrial wastewater collected from the Kanpur industrial region, containing hexavalent chromium (Cr<sup>6+</sup>), lead (Pb<sup>2+</sup>), cadmium (Cd<sup>2+</sup>), and textile dyes.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of Functionalized 1H-Pyrazole Derivatives: Investigating Fluorescence, and In Vitro Anti-Inflammatory Activity","authors":"Qingdian Ma, Houwei Fu, Hongru Wu, Li Ma, Jian Li, Baohan Zhou","doi":"10.1134/S1070363226602280","DOIUrl":"10.1134/S1070363226602280","url":null,"abstract":"<p>The synthesis of a series of fluorescent 1<i>H</i>-pyrazole derivatives was described. The photophysical properties of the synthesized derivatives were investigated using ultraviolet-visible (UV-Vis) spectroscopy and fluorescence spectroscopy. The results showed that the synthesized compounds exhibited only minor variations in fluorescence emission in solution; upon aggregation into the solid state, the emission wavelength exhibited a significant red shift and the emission intensity was markedly enhanced, among which eight compounds displayed typical aggregation-induced emission (AIE) characteristics. To investigate the anti-inflammatory potential of our multifunctional synthesized compounds, we evaluated the inhibitory effect of synthetic compounds on LPS-induced inflammation in MH-S cells. The anti-inflammatory activity screening revealed that three target compounds possessed significant anti-inflammatory activities.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilya G. Kolmakov, Dmitrii A. Grishin, Elena K. Beloglazkina, Roman L. Antipin, Elena V. Kudryashova, Anna A. Skuredina
{"title":"Hydroxypropyl-β-Cyclodextrin Affects the Solubility of Novel Fluoroquinolone with Potential Antibacterial Action","authors":"Ilya G. Kolmakov, Dmitrii A. Grishin, Elena K. Beloglazkina, Roman L. Antipin, Elena V. Kudryashova, Anna A. Skuredina","doi":"10.1134/S1070363226601249","DOIUrl":"10.1134/S1070363226601249","url":null,"abstract":"<p>A novel antibacterial fluoroquinolone molecule (PFQA) that demonstrated poor solubility in the biologically relevant media was synthesized. Influence of 2-hydroxypropyl-β-cyclodextrin (HPβCD) on the physicochemical and potential biological properties of PFQA was studied. HPβCD increases the PFQA’s solubility (up to 2 times), decreases the drug’s particle size (up to 100 nm) and significantly enhances particle’s homogeneity. The mechanism of complex formation was investigated by FTIR and <sup>1</sup>H NMR. PFQA has two binding sites for HPβCD with <i>K</i><sub>d1</sub> = (5.8 ± 0.8) × 10<sup>–4</sup> M and <i>K</i><sub>d2</sub> = (2.9 ± 0.3) × 10<sup>–3</sup> M. The negative cooperativity is possibly due to the steric effects proved in Scatchard and Hill coordinates. The results highlight the great advantage of PFQA−HPβCD comparing to free PFQA for further studies <i>in vitro</i> and <i>in vivo</i>.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regioselective Electrophilic Sulfenylation of 10-Azacorroles","authors":"Guoru Chen, Zhonglan Wei, Xiaofang Li","doi":"10.1134/S1070363226602668","DOIUrl":"10.1134/S1070363226602668","url":null,"abstract":"<p>10-Azacorroles react with arylsulfenyl chlorides to obtain the arylsulfenyl-substituted 10-azacorroles in moderate yields. The structures of all the products were characterized thoroughly by NMR, HRMS, and X-ray crystallographic analysis.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. R. Gajipara, R. N. Dholakiya, P. K. Patel, B. Y. Patel
{"title":"Reline-Based DES-Assisted Synthesis of C3-Indole-Pyrazole Schiff Bases: Integrated Antioxidant, Antibacterial and Molecular Docking Studies","authors":"D. R. Gajipara, R. N. Dholakiya, P. K. Patel, B. Y. Patel","doi":"10.1134/S1070363226600670","DOIUrl":"10.1134/S1070363226600670","url":null,"abstract":"<p>A series of indole–pyrazole Schiff base conjugates was synthesized and biologically evaluated, revealing notable antioxidant and antibacterial activities. In free radical scavenging assays, several derivatives exhibited concentration-dependent efficacy, with specific fluorinated, nitrated and methoxy substituted analogues demonstrating the strongest antioxidant performance in both DPPH and hydrogen peroxide scavenging assays, achieving high levels of radical inhibition at 5 mg/mL relative to standard ascorbic acid. Antibacterial screening against <i>S. aureus</i>, <i>E. coli</i>, <i>P. polymyxa</i>, and <i>P. aeruginosa</i> identified key active derivatives exhibiting substantial growth inhibition across multiple strains, with <i>P. aeruginosa</i> displaying exceptional sensitivity. Molecular docking studies corroborated the experimental findings, demonstrating favorable binding interactions of the lead compounds within the active sites of bacterial DNA gyrase targets. Notably, the 4-fluorobenzylidene derivative displayed the highest binding affinity toward both <i>S. aureus</i> DNA gyrase and <i>P. aeruginosa</i> DNA gyrase B, driven by strong and stable ligand–protein interactions. Validation of the docking protocol <i>via</i> self-docking of co-crystallized ligands yielded acceptable root-mean-square deviation (RMSD) values (<3 Å), confirming the predictive reliability of the computational model. Overall, the integrated biological and computational insights underscore the lead fluoro-substituted hybrid as a promising multifunctional candidate, demonstrating that strategic aryl ring substitutions on the indole–pyrazole framework critically modulate both antioxidant and antibacterial potency.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evgeny S. Ostroglyadov, Ol’ga S. Vasil’eva, Ruslan I. Baichurin, Sergei V. Makarenko, Daut R. Islamov, Ol’ga B. Babaeva, Igor A. Litvinov
{"title":"Synthesis and Structure of Methyl 4-Het(aryl)-2-pyrrolidone-3-methoxycarbonylethyl-3-carboxylates","authors":"Evgeny S. Ostroglyadov, Ol’ga S. Vasil’eva, Ruslan I. Baichurin, Sergei V. Makarenko, Daut R. Islamov, Ol’ga B. Babaeva, Igor A. Litvinov","doi":"10.1134/S1070363226601742","DOIUrl":"10.1134/S1070363226601742","url":null,"abstract":"<p>Methyl 4-het(aryl)-3-methoxycarbonylethyl-2-pyrrolidone-3-carboxylates were obtained by the reaction of 4-het(aryl)-3-methoxycarbonylethyl-2-pyrrolidone-3-carboxylates with ethyl acrylate. The structure of the obtained compounds was confirmed by physicochemical methods (<sup>1</sup>H, <sup>13</sup>C{<sup>1</sup>H} NMR, <sup>1</sup>H–<sup>13</sup>C HMQC, <sup>1</sup>H–<sup>13</sup>C HMBC spectroscopy) and single-crystal X-ray diffraction analysis.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Artem A. Amirkhanyan, Ekaterina S. Ovsienko, Darya Yu. Lukina, Victor V. Dotsenko, Ilya N. Chernov, Sergey N. Ovcharov, Nicolai A. Aksenov, Inna V. Aksenova, Sergey G. Krivokolysko
{"title":"Reaction of γ-Bromoacetoacetanilide with 2-Thioxo-1,2-dihydropyridine-3-carbonitriles: Synthesis and Properties of New β-Ketoamides Bearing Nicotinonitrile and Thieno[2,3-b]pyridine Fragments","authors":"Artem A. Amirkhanyan, Ekaterina S. Ovsienko, Darya Yu. Lukina, Victor V. Dotsenko, Ilya N. Chernov, Sergey N. Ovcharov, Nicolai A. Aksenov, Inna V. Aksenova, Sergey G. Krivokolysko","doi":"10.1134/S1070363226604205","DOIUrl":"10.1134/S1070363226604205","url":null,"abstract":"<p>The reaction of γ-bromoacetoacetanilide with 2-thioxo-1,2-dihydropyridine-3-carbonitriles afforded novel β-ketoamides bearing a heterocyclic fragment, namely 4-{(3-cyanopyridin-2-yl)thio}-3-oxo-<i>N</i>-phenylbutanamides and 3-(3-aminothieno[2,3-<i>b</i>]pyridin-2-yl)-3-oxo-<i>N</i>-phenylpropanamides. The structure of the reaction products was found to be critically dependent on the reaction conditions: under mild conditions, the <i>S</i>-alkylation products are formed, whereas upon heating in the presence of bases, these intermediates undergo Thorpe–Ziegler isomerization to give the corresponding thienopyridine β-ketoamides. Prolonged heating of the latter leads to further cascade cyclization, affording 4-hydroxythieno[2,3-<i>b</i>:4,5-<i>b'</i>]dipyridin-2(1<i>H</i>)-ones. All synthesized compounds were subjected to <i>in silico</i> bioavailability assessment and molecular docking to identify potential protein targets.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reactions of Dialkyl Chloroethynylphosphonates with Acid Bishydrazides","authors":"Elizaveta A. Gerasimova, Dmitry M. Egorov","doi":"10.1134/S107036322660133X","DOIUrl":"10.1134/S107036322660133X","url":null,"abstract":"<p>Bishydrazides of a series of aliphatic and aromatic dicarboxylic acids were obtained. Their reaction with dialkyl chloroethynylphosphonate enabled the synthesis of new alkyl(phenyl)bis-1,3,4-oxadiazoles. It was shown that the reaction proceeds under mild conditions, does not require the use of catalysts, and affords exclusively the target products with high chemo- and regioselectivity.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Artem A. Amirkhanyan, Tatyana R. Hagur, Nicolai A. Aksenov, Inna V. Aksenova, Victor V. Dotsenko
{"title":"Synthesis, Structure and Properties of N-Phenyl-2-(thiazol-4-yl)acetamides","authors":"Artem A. Amirkhanyan, Tatyana R. Hagur, Nicolai A. Aksenov, Inna V. Aksenova, Victor V. Dotsenko","doi":"10.1134/S1070363226602553","DOIUrl":"10.1134/S1070363226602553","url":null,"abstract":"<p>γ-Bromoacetoacetanilide reacts with the Michael adducts obtained from the reaction of cyanothioacetamide with aromatic aldehydes and Meldrum’s acid to form (<i>E</i>)-2-{2-[2-aryl-1-cyanovinyl]thiazol-4-yl}-<i>N</i>-phenylacetamides. These compounds were also synthesized via a convergent synthesis from aldehydes, cyanothioacetamide, and γ-bromoacetoacetanilide. Additionally, new 2-(thiazol-4-yl)acetanilides were synthesized by the Hantzsch reaction of γ-bromoacetoacetanilide with cyanothioacetamide or with 3-(arylamino)-2-cyanothioacrylamides. For all new compounds, <i>in silico</i> predictive analysis and molecular docking were performed to determine bioavailability parameters and identify potential protein targets.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"96 9","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148926513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}