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An Effective Dual-Wavelength Fluorescent Sensor for ClO− Detection 一种用于ClO−检测的有效双波长荧光传感器
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225603205
Yichen Xu, Ming Yue, Yun-Hui Zhao, Zilong Tang, Tao Guo
{"title":"An Effective Dual-Wavelength Fluorescent Sensor for ClO− Detection","authors":"Yichen Xu,&nbsp;Ming Yue,&nbsp;Yun-Hui Zhao,&nbsp;Zilong Tang,&nbsp;Tao Guo","doi":"10.1134/S1070363225603205","DOIUrl":"10.1134/S1070363225603205","url":null,"abstract":"<p>A novel dual-wavelength fluorescent probe targeting hypochlorite was successfully designed and synthesized, with its molecular structure unambiguously characterized by <sup>1</sup>H, <sup>13</sup>C NMR spectroscopy and high-resolution mass spectrometry. This “off-on” type sensor demonstrates a distinctive dual-emission response at 494 and 599 nm upon hypochlorite activation. The proposed response mechanism, involving hypochlorite-induced specific structural modulation, not only achieves remarkable target specificity but also effectively suppresses background interference through its ratiometric detection modality. Importantly, both emission channels exhibit excellent linear correlations (R<sup>2</sup> &gt; 0.995) with hypochlorite concentrations in the biologically relevant range of 50–180 μM, demonstrating its potential for quantitative analysis in complex matrices.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2169 - 2176"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diastereoselective Alkylation of an Oxazolidinone Chiral Auxiliary 恶唑烷酮手性助剂的非对映选择性烷基化
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S107036322560331X
O. Bsharat
{"title":"Diastereoselective Alkylation of an Oxazolidinone Chiral Auxiliary","authors":"O. Bsharat","doi":"10.1134/S107036322560331X","DOIUrl":"10.1134/S107036322560331X","url":null,"abstract":"<p>Asymmetric synthesis, the part of diastereoselective alkylation of a chiral auxiliary is an important tool in organic synthesis. In this work an α-methyl, non-natural amino acid (NNAA) building block equipped with a phthalimide group tail was prepared. This work describes the generation of the lithium enolate oxazolidin-2-ones chiral auxiliary derived from non-natural amino acid and quenching this enolate with 2-chloromethyl-isoindole-1,3-dione, to provide an α-methyl, non-natural amino acid (NNAA) building block equipped with a phthalimide group in good yield in multistep synthesis with no sign of any minor diastereomers. The identity of new compound was confirmed by <sup>1</sup>H, <sup>13</sup>C NMR and mass spectrometry. With this building block in hand, peptides can be produced for evaluation in a variety of therapeutic areas in drug discovery.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2187 - 2191"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Synthesis and Biological Evaluation of Novel Acyl Hydrazide Derivatives Based on Heterocyclic Core as Antibacterial Agents 基于杂环核心的新型酰肼类抗菌剂的合成及生物学评价
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225080018
Yongzhong Li, Tao Ye, Qin Yuan, Zhiwen Zhou, Huaming Hu, Yi Xin
{"title":"Erratum to: Synthesis and Biological Evaluation of Novel Acyl Hydrazide Derivatives Based on Heterocyclic Core as Antibacterial Agents","authors":"Yongzhong Li,&nbsp;Tao Ye,&nbsp;Qin Yuan,&nbsp;Zhiwen Zhou,&nbsp;Huaming Hu,&nbsp;Yi Xin","doi":"10.1134/S1070363225080018","DOIUrl":"10.1134/S1070363225080018","url":null,"abstract":"","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2307 - 2307"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable Biogenic Synthesis of Europium Oxide Nanoparticles from Durian Leaf Extract for Antibacterial and Antioxidant Application 可持续生物合成用于抗菌和抗氧化的氧化铕纳米颗粒
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225602121
M. Manimaran, N. Moorthy, M. Gurumoorthy, A. Muthuvel, Eman Alhomaidi, Samiah Alhabardi
{"title":"Sustainable Biogenic Synthesis of Europium Oxide Nanoparticles from Durian Leaf Extract for Antibacterial and Antioxidant Application","authors":"M. Manimaran,&nbsp;N. Moorthy,&nbsp;M. Gurumoorthy,&nbsp;A. Muthuvel,&nbsp;Eman Alhomaidi,&nbsp;Samiah Alhabardi","doi":"10.1134/S1070363225602121","DOIUrl":"10.1134/S1070363225602121","url":null,"abstract":"<p>Europium oxide (Eu<sub>2</sub>O<sub>3</sub>) nanoparticles were biosynthesized using durian leaf extract via a biosynthesis technique. The structural properties were evaluated through XRD study, confirming a cubic structure with a regular crystallite size of 12 nm. Optical investigation using UV-Vis spectroscopy revealed an absorption peak at 258 nm, conforming to a band gap energy of 4 eV. The DLS and zeta potential analysis demonstrated a nanoparticles size 57 nm and a surface charge of –22.6 mV, indicating high stability and dispersion. Morphological analysis using HR-TEM inveterate the spherical shaped and monodispersed of Eu<sub>2</sub>O<sub>3</sub> nanoparticles, with a regular size of 20 nm. FT-IR investigation recognized functional groups involved in nanoparticles formation and stability. Photoluminescence analysis showed emissions at 582, 617, 662 and 696 nm, with the dominant peak at 617 nm confirming the cubic structure. Antibacterial activity against <i>B. anthracis</i> and <i>K. pneumonia</i> exhibited higher efficacy for the gram-negative strain, attributed to smaller nanoparticles size and increased surface area. Antioxidant activity evaluated via DPPH assay showed effective free radical scavenging with an IC<sub>50</sub> value of 37.42 µg/mL. These results highlight the prospective of synthesized nanoparticles for biomedical and environmental applications due to their stability, small size, and enhanced antibacterial and antioxidant goods.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2072 - 2080"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large Scale Synthesis 3D Architecture Composites of Reduced Graphene Oxide with MoS2 or WS2 Nanoparticles: Oxygen Reduction Reaction 氧化石墨烯与二硫化钼或WS2纳米粒子的大规模合成三维结构复合材料：氧还原反应
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363224613140
P. Routh
{"title":"Large Scale Synthesis 3D Architecture Composites of Reduced Graphene Oxide with MoS2 or WS2 Nanoparticles: Oxygen Reduction Reaction","authors":"P. Routh","doi":"10.1134/S1070363224613140","DOIUrl":"10.1134/S1070363224613140","url":null,"abstract":"<p>Composite materials have recently gained significant importance in energy-related fields such as fuel cells, solar cells, and supercapacitors. For industrial applications, the development of cost-effective and scalable production methods for these materials is highly desirable. Among emerging materials, metal chalcogenide nanoparticles (MCNPs) have shown valuable potential in biomedical applications. However, their direct application in energy devices remains limited due to poor electrochemical performance. To enhance their performance in energy-related applications, a promising strategy involves synthesizing composite materials by combining MCNPs with suitable conductive materials. Reduced graphene oxide (rGO) is particularly attractive for this purpose due to its excellent electrical conductivity, high surface area, and favorable structural properties. While MCNPs are semiconducting with desirable optical properties, their activity in energy devices is suboptimal. Therefore, integrating MCNPs with rGO can create synergistic effects that improve overall device performance. In this study, we report the synthesis of MCNPs–reduced graphene oxide (MCG) composite materials through a simple one-step hydrothermal treatment using graphene oxide and MCNPs. The resulting MCG composites exhibited excellent electrocatalytic activity towards the oxygen reduction reaction (ORR), following a favorable four-electron transfer pathway in an alkaline medium.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"1936 - 1945"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Synthesis and Antifungal Activities of Novel 2-Aryl-3-amidyl-1,3-benzoxazine Derivatives 新型2-芳基-3-酰胺基-1,3-苯并恶嗪衍生物的高效合成及抑菌活性研究
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225601802
Zilong Tang, Guanyu Wang, Xinxing Li, Yichao Wan, Lifen Peng
{"title":"Efficient Synthesis and Antifungal Activities of Novel 2-Aryl-3-amidyl-1,3-benzoxazine Derivatives","authors":"Zilong Tang,&nbsp;Guanyu Wang,&nbsp;Xinxing Li,&nbsp;Yichao Wan,&nbsp;Lifen Peng","doi":"10.1134/S1070363225601802","DOIUrl":"10.1134/S1070363225601802","url":null,"abstract":"<p>A diverse array of novel 2-aryl-3-amidyl-1,3-benzoxazine compounds were synthesized in 54–93% yields by La(OTf)<sub>3</sub>-catalyzed reactions of 2-[(2-hydroxybenzyl)amino]acetamides with aldehydes. The structures of the prepared compounds were characterized by IR, <sup>1</sup>H, <sup>13</sup>C NMR and HRMS methods. The antifungal activities of the compounds against plant fungi were evaluated, demonstrating the highest activity of 85.0% against <i>P</i>. <i>capsici</i> by 2-(2-nitrophenyl)-3-[(phenylcarbamoyl)methyl]-1,3-benzoxazine.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2019 - 2027"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of the Nature of Diisocyanate on the Synthesis Conditions and Properties of Urethane Thermoplastic Elastomers 二异氰酸酯的性质对聚氨酯热塑性弹性体合成条件和性能的影响
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225603229
I. N. Bakirova, T. A. Mineeva
{"title":"Influence of the Nature of Diisocyanate on the Synthesis Conditions and Properties of Urethane Thermoplastic Elastomers","authors":"I. N. Bakirova,&nbsp;T. A. Mineeva","doi":"10.1134/S1070363225603229","DOIUrl":"10.1134/S1070363225603229","url":null,"abstract":"<p>Urethane thermoplastic elastomers were synthesized from oligobutylene glycol adipate and diisocyanate using the aromatic diol 2,2′-[propane-2,2-diylbis(<i>p</i>-phenyleneoxy)]diethanol as a chain extender. 4,4′-Diphenylmethane diisocyanate and isophorone diisocyanate were used as diisocyanates. The synthesis of a thermoplastic elastomer based on cycloaliphatic diisocyanate was carried out in the presence of an organotin catalyst. It was found that replacing the aromatic diisocyanate with a cycloaliphatic one led to the transition of the amorphous polymer into a crystalline one. At the same time, its deformation and strength properties, hardness, and light resistance increased.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2164 - 2168"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Benzothiazole-Pyrazole Hybrids as Anticancer Agents: Synthesis, In Vitro Testing, Molecular Docking and Dynamic Simulation Study 苯并噻唑-吡唑复合物抗癌研究：合成、体外测试、分子对接和动态模拟研究
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225601851
D. Wanode, D. Nandurkar, P. Khedekar
{"title":"Exploring Benzothiazole-Pyrazole Hybrids as Anticancer Agents: Synthesis, In Vitro Testing, Molecular Docking and Dynamic Simulation Study","authors":"D. Wanode,&nbsp;D. Nandurkar,&nbsp;P. Khedekar","doi":"10.1134/S1070363225601851","DOIUrl":"10.1134/S1070363225601851","url":null,"abstract":"<p>In this study, we present comprehensive work on synthesis, and anticancer evaluation of a new series of benzothiazole-pyrazole hybrids. The structures of the synthesized compounds were confirmed using a comprehensive suite of analytical techniques, including <sup>1</sup>H, <sup>13</sup>C NMR, FT-IR, and HRMS. Among the series, the hybrid compound featuring a <i>para</i>-fluorophenyl substituent on the pyrazole ring exhibited notable in vitro anticancer activity compared to standard 5-fluorouracil against the MCF-7 cell line. To support the experimental findings, in silico studies were performed using physics-based approaches such as AutoDock Vina, molecular dynamics (MD) simulations, and MM-GBSA calculations. These studies revealed strong binding affinity of the compound toward the target protein (PDB ID: 4AGC), with key interactions involving amino acid residues ALA113A, ILE120A, LEU121A, ILE124A, LEU201A, and ILE226A. Overall, this compound emerges as a promising lead candidate for further development in anticancer drug discovery.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2028 - 2041"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Propargyl-Containing Derivatives of Remantadine, 4-Aminoantipyrine and Streptocide Linked by Hydroxybenzaldehyde Linkers 羟基苯甲醛连接的氨基安替比林和杀链药的含丙炔衍生物
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225602832
E. A. Dikusar, E. N. Margun, E. A. Akishina, I. A. Kolesnik, S. S. Kovalskaya, H. Zhou, V. I. Potkin
{"title":"Propargyl-Containing Derivatives of Remantadine, 4-Aminoantipyrine and Streptocide Linked by Hydroxybenzaldehyde Linkers","authors":"E. A. Dikusar,&nbsp;E. N. Margun,&nbsp;E. A. Akishina,&nbsp;I. A. Kolesnik,&nbsp;S. S. Kovalskaya,&nbsp;H. Zhou,&nbsp;V. I. Potkin","doi":"10.1134/S1070363225602832","DOIUrl":"10.1134/S1070363225602832","url":null,"abstract":"<p>(<i>E</i>)-Azomethines were synthesized in 70–77% yields by condensation of rimantadine, 4-aminoantipyrine, and streptocide with propargyl ethers of hydroxybenzaldehydes. Varying the mutual arrangement of the pharmacophoric groups linked via hydroxybenzaldehyde linkers allows to form structures of various geometries. Using two propargyl-containing azomethines (4-aminoantipyrine derivatives) as an example, 1,4-disubstituted 1,2,3-triazoles were obtained under the conditions of the Cu(I)-catalyzed azide-alkyne cycloaddition reaction.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2133 - 2141"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH-Sensitive Paclitaxel Prodrug Incorporating Zanthoxylum bungeanum Extract for Targeted Non-Small Cell Lung Cancer Therapy 含花椒提取物的ph敏感性紫杉醇前药靶向治疗非小细胞肺癌
IF 0.8 4区 化学
Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI: 10.1134/S1070363225602789
Z. Xu, Y. Li, L. Zhang
{"title":"pH-Sensitive Paclitaxel Prodrug Incorporating Zanthoxylum bungeanum Extract for Targeted Non-Small Cell Lung Cancer Therapy","authors":"Z. Xu,&nbsp;Y. Li,&nbsp;L. Zhang","doi":"10.1134/S1070363225602789","DOIUrl":"10.1134/S1070363225602789","url":null,"abstract":"<p>In this study, we developed a lung cancer-activated prodrug nanoplatform, which combines paclitaxel (PTX), the fluorescent molecule BODIPY-OH, and compound, a natural extract from Zanthoxylum bungeanum. PTX and BODIPY were covalently linked to form PTX-NH-BDP, which self-assembled with Pluronic F-127 into water-dispersible nanoparticles. The compound was then loaded to enhance therapeutic efficacy. The system enables real-time fluorescence imaging for precise intracellular drug tracking and controlled release. In vitro studies showed that the nanoparticles significantly inhibit NSCLC cell proliferation, migration, and bcl-2 expression. This platform improves paclitaxel’s solubility and release profile, offering a promising strategy for enhanced NSCLC therapy.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2123 - 2132"},"PeriodicalIF":0.8,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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