Efficient Synthesis and Antifungal Activities of Novel 2-Aryl-3-amidyl-1,3-benzoxazine Derivatives

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI:10.1134/S1070363225601802

Zilong Tang, Guanyu Wang, Xinxing Li, Yichao Wan, Lifen Peng

引用次数: 0

Abstract

A diverse array of novel 2-aryl-3-amidyl-1,3-benzoxazine compounds were synthesized in 54–93% yields by La(OTf)₃-catalyzed reactions of 2-[(2-hydroxybenzyl)amino]acetamides with aldehydes. The structures of the prepared compounds were characterized by IR, ¹H, ¹³C NMR and HRMS methods. The antifungal activities of the compounds against plant fungi were evaluated, demonstrating the highest activity of 85.0% against P. capsici by 2-(2-nitrophenyl)-3-[(phenylcarbamoyl)methyl]-1,3-benzoxazine.

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新型2-芳基-3-酰胺基-1,3-苯并恶嗪衍生物的高效合成及抑菌活性研究

利用La(OTf)3催化2-[（2-羟基苄基）氨基]乙酰酰胺与醛的反应，以54-93%的产率合成了一系列新的2-芳基-3-氨基-1,3-苯并恶嗪化合物。用IR、1H、13C NMR和HRMS等方法对化合物的结构进行了表征。结果表明，2-（2-硝基苯基）-3-[（苯基氨基甲酰）甲基]-1,3-苯并恶嗪对辣椒疫病菌的抑菌活性最高，达85.0%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.