{"title":"pH-Sensitive Paclitaxel Prodrug Incorporating Zanthoxylum bungeanum Extract for Targeted Non-Small Cell Lung Cancer Therapy","authors":"Z. Xu, Y. Li, L. Zhang","doi":"10.1134/S1070363225602789","DOIUrl":null,"url":null,"abstract":"<p>In this study, we developed a lung cancer-activated prodrug nanoplatform, which combines paclitaxel (PTX), the fluorescent molecule BODIPY-OH, and compound, a natural extract from Zanthoxylum bungeanum. PTX and BODIPY were covalently linked to form PTX-NH-BDP, which self-assembled with Pluronic F-127 into water-dispersible nanoparticles. The compound was then loaded to enhance therapeutic efficacy. The system enables real-time fluorescence imaging for precise intracellular drug tracking and controlled release. In vitro studies showed that the nanoparticles significantly inhibit NSCLC cell proliferation, migration, and bcl-2 expression. This platform improves paclitaxel’s solubility and release profile, offering a promising strategy for enhanced NSCLC therapy.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 8","pages":"2123 - 2132"},"PeriodicalIF":0.8000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363225602789","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, we developed a lung cancer-activated prodrug nanoplatform, which combines paclitaxel (PTX), the fluorescent molecule BODIPY-OH, and compound, a natural extract from Zanthoxylum bungeanum. PTX and BODIPY were covalently linked to form PTX-NH-BDP, which self-assembled with Pluronic F-127 into water-dispersible nanoparticles. The compound was then loaded to enhance therapeutic efficacy. The system enables real-time fluorescence imaging for precise intracellular drug tracking and controlled release. In vitro studies showed that the nanoparticles significantly inhibit NSCLC cell proliferation, migration, and bcl-2 expression. This platform improves paclitaxel’s solubility and release profile, offering a promising strategy for enhanced NSCLC therapy.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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