Autopsy and Case ReportsPub Date : 2023-12-15eCollection Date: 2023-01-01DOI: 10.4322/acr.2023.461
Kaushlendra Kumar, Ariba Zaidi, Nuzhat Husain
{"title":"Ovarian hydatid cyst: an uncommon site of presentation.","authors":"Kaushlendra Kumar, Ariba Zaidi, Nuzhat Husain","doi":"10.4322/acr.2023.461","DOIUrl":"10.4322/acr.2023.461","url":null,"abstract":"<p><p>Hydatid cyst is a parasitic infestation caused by Echinococcus larvae. Hydatid cyst of the ovary is a highly unusual presentation. Herein, we present a case of a young woman who complained of episodic lower abdominal pain. Ultrasound of the abdomen revealed a multi-cystic left adnexal mass measuring 86 mm x 67 mm. A possibility of ovarian cystic neoplasm was suggested. Unilateral salpingo-oophorectomy was performed. On histopathological examination, a cyst measuring 8.0 x 5.5 x 4.5 cm was found, replacing the entire ovary. The cyst cavity was filled with serous fluid and multiple pearly white membranous structures, giving a multiloculated appearance. Microscopic examination showed a cyst lined by a lamellar membrane containing protoscolices and hooklets. Hydatid disease is a zoonotic ailment caused by tapeworms <i>(Echinococcus granulosus</i> or, less commonly, <i>Echinococcus multilocularis)</i>. The definitive hosts are carnivores. Humans are the accidental intermediate hosts. The hydatid cyst commonly affects the liver and the lungs. The primary hydatid cyst of the ovary is quite rare, with few case reports in the literature. In most cases, symptoms are vague, and the lesion is misdiagnosed as benign or malignant ovarian cystic neoplasm on clinical and radiological examination. Ovarian hydatid cyst is treated by surgery with ovarian cystectomy as the gold standard. The possibility of a hydatid cyst should be kept under differential diagnoses while evaluating the cystic diseases of the ovary.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023461"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anorectal balloon cell melanoma: a rare variant.","authors":"Priyanka Sameer, Pallavi Srivastava, Saumya Shukla, Nuzhat Husain","doi":"10.4322/acr.2023.459","DOIUrl":"10.4322/acr.2023.459","url":null,"abstract":"<p><p>Balloon cell melanoma is a rare presentation of malignant melanoma, usually on the skin, with less than 100 cases reported. Mucosal BCM is even rarer, with only one case of anorectal BCM reported in English literature. The diagnosis is based on the histopathologic findings of a tumor composed of large, foamy melanocytes, with or without pigmentation, and confirmed by immunohistochemical studies showing expression for melanocytic markers. The foam cell appearance of the tumor cells and the lack of melanin pigment lead to a diagnostic dilemma, mostly when presented at an unusual location. Herein, we report a case of balloon cell melanoma at the anorectal junction in a 73-year-old male patient complaining of constipation and bleeding per rectum. Surgical resection was performed with no evidence of recurrence after three years of close follow-up. We believe this case will raise awareness among the medical community to consider this tumor a differential diagnosis in rectal masses.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023459"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rosai-Dorfman disease of the oral cavity.","authors":"Abir Charfeddine, Mounir Omami, Marwa Garma, Ahlem Bellalah, Sameh Sioud, Jamil Selmi","doi":"10.4322/acr.2023.463","DOIUrl":"10.4322/acr.2023.463","url":null,"abstract":"<p><p>First described by J Rosai and R F Dorfman in 1969, Rosai-Dorfman disease (RDD) is a benign, self-limiting histiocytosis of unknown etiology. It is usually seen in the first two decades of life. The most frequent clinical presentation is painless, bilateral cervical lymphadenopathy accompanied by fever, weight loss, and an elevated ESR. However, RDD without nodal involvement is extremely rare, and the most common extranodal location is the head and neck region, mainly affecting the nasal cavity, pharynx, and paranasal sinuses. Oral location of RDD is occasional; according to our knowledge, only 17 cases of oral Rosai-Dorfman disease without lymph node involvement have been found in the literature. Because of the rarity of these isolated oral presentations, the clinical and radiological aspects need to be more studied. This article aims to present a rare case of oral Rosai-Dorfman disease without nodal involvement, detail the clinical and radiological signs, and the treatment strategy used in our patient.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023463"},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autopsy and Case ReportsPub Date : 2023-11-27eCollection Date: 2023-01-01DOI: 10.4322/acr.2023.460
Saikat Mitra
{"title":"Cystic hypersecretory lesions - invasive breast carcinoma-spectrum of a rare tumour.","authors":"Saikat Mitra","doi":"10.4322/acr.2023.460","DOIUrl":"10.4322/acr.2023.460","url":null,"abstract":", associated CHH in the surrounding parenchyma indicates the invasive tumor as an invasive CHC. The available literature is limited; however, most cases of invasive CHC are high-grade solid tumors, as encountered in this case","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023460"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autopsy and Case ReportsPub Date : 2023-11-27eCollection Date: 2023-01-01DOI: 10.4322/acr.2023.458
Arvind Kumar, Tushar Kalonia, Akanksha Gupta, Ravi Hari Phulware
{"title":"Gallbladder adenocarcinoma skin metastasis.","authors":"Arvind Kumar, Tushar Kalonia, Akanksha Gupta, Ravi Hari Phulware","doi":"10.4322/acr.2023.458","DOIUrl":"10.4322/acr.2023.458","url":null,"abstract":"moderate cytoplasm. A few cells showed cytoplasmic clearing. The peritumoral desmoplastic reaction was also identified with intratumorally brisk mitotic figures. Focal areas of necrosis with acute and chronic inflammatory infiltrate were also identified. Immunohistochemistry revealed tumor cells to be diffusely positive for cytokeratin 7 (CK7) and CK19 (Figure 1C and 1D) and negative for CK20, thyroid transcription factor (TTF-1), Gross Cystic Disease Fluid Protein-15 (GCDFP-15), mammaglobin, Hepatocyte Paraffin 1 (Hep Par1), Paired box gene 8 (PAX-8) and Wilms tumor gene 1 (WT1). An abdominal computed tomography scan on imaging workup revealed a gallbladder mass with multiple liver lesions and brain metastasis. Based on immunohistochemistry and imaging findings, the diagnosis was metastatic gall bladder carcinoma to the scalp.","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023458"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autopsy and Case ReportsPub Date : 2023-11-27eCollection Date: 2023-01-01DOI: 10.4322/acr.2023.456
Maria Aparecida Marchesan Rodrigues, Bruno Miamoto, Rosa Marlene Viero
{"title":"Necrotizing amebic colitis in an elder patient: an unexpected autopsy finding.","authors":"Maria Aparecida Marchesan Rodrigues, Bruno Miamoto, Rosa Marlene Viero","doi":"10.4322/acr.2023.456","DOIUrl":"10.4322/acr.2023.456","url":null,"abstract":"<p><p>Necrotizing amebic colitis is an uncommon amebiasis complication associated with high mortality. We present a case of necrotizing amebic colitis in an old patient whose diagnosis was revealed at postmortem examination. An 81-year-old man died at home without medical attention. The postmortem examination revealed ulcers involving the entire colon and intestinal perforation. The ulcers were large, geographic, and necrotizing, extending from the cecum to the rectum. The histological examination disclosed the infectious etiology by showing amebic trophozoites at the base of the ulcers. No extra-intestinal lesions were found. No information about previous episodes of dysentery or travel could be obtained. The potential role of aging or drug-causing immunosuppression and the evolution of chronic and latent intestinal infection to a severe and invasive form of amebiasis is discussed. This case reinforces the value of postmortem examination for diagnosing diseases not clinically identified.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023456"},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autopsy and Case ReportsPub Date : 2023-11-16eCollection Date: 2023-01-01DOI: 10.4322/acr.2023.457
Fareed Rajack, Shawn Medford, Tammey Naab
{"title":"<i>Clostridioides difficile</i> infection leading to fulminant colitis with toxic megacolon.","authors":"Fareed Rajack, Shawn Medford, Tammey Naab","doi":"10.4322/acr.2023.457","DOIUrl":"10.4322/acr.2023.457","url":null,"abstract":"<p><p><i>Clostridioidesdifficile</i> infection (CDI) is the culprit of millions of nosocomial infections in the United States. Programs that successfully decrease its incidence, therefore, render cost savings for the healthcare system. Toxic megacolon and perforation are two of the most significant complications with increased mortality rates. We report a 23-year-old nursing home resident hospitalized for fever, cough, and green sputum. After 3 days of antibiotic therapy, he developed abdominal distension, diarrhea, and vomiting and underwent a total colectomy. The colon was dilated to a maximum of 11 cm with markedly edematous mucosa and yellow pseudomembranes. Qualitative PCR of the stool detected <i>Clostridioides difficile</i> toxin B gene. While there is no consensus for the required interval between antibiotic treatment and CDI, this presentation 3 days after starting the antibiotic therapy is earlier than most proposed ranges.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023457"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autopsy and Case ReportsPub Date : 2023-11-13eCollection Date: 2023-01-01DOI: 10.4322/acr.2023.454
Maria Emília Mota, Dandara Menezes de Araujo Oliveira, Yuri de Lima Medeiros, Maria Stella Moreira, Rodrigo Nascimento Lopes, Fábio Abreu Alves, Brendo Vinícius Rodrigues Louredo, Pablo Agustin Vargas, José Divaldo Prado
{"title":"Gingival cyst of the adult.","authors":"Maria Emília Mota, Dandara Menezes de Araujo Oliveira, Yuri de Lima Medeiros, Maria Stella Moreira, Rodrigo Nascimento Lopes, Fábio Abreu Alves, Brendo Vinícius Rodrigues Louredo, Pablo Agustin Vargas, José Divaldo Prado","doi":"10.4322/acr.2023.454","DOIUrl":"10.4322/acr.2023.454","url":null,"abstract":"<p><p>The gingival cyst of the adult (GCA) is a rare odontogenic cyst, consisting of 0.3% of all odontogenic cysts. This case report, based on CARE guidelines for case reports, aims to present a case of a 52-year-old female patient with a symptomatic translucent nodule in the upper left anterior gingiva, measuring approximately 6mm. Excisional biopsy was performed, and the histological examination revealed multiple cystic cavities lined by the squamous epithelium of varying thickness with focal areas of nodular thickenings. The presence of clusters of cells with clear cytoplasm within epithelial thickenings was observed. PAS staining was negative in clear cells. The diagnosis of the GCA was established. Despite its rarity, GCA should be considered in the differential diagnosis of gingival lesions. Conservative surgical treatment proved to be effective, with no signs of recurrence.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023454"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biliary adenofibroma: a precursor lesion of intrahepatic cholangiocarcinoma.","authors":"Mayur Parkhi, Rashmi Joshi, Manish Kumar, Aditi Sharma, Suvradeep Mitra, Lileswar Kaman","doi":"10.4322/acr.2023.453","DOIUrl":"10.4322/acr.2023.453","url":null,"abstract":"<p><p>Biliary adenofibroma (BAF) is an uncommon liver tumor with a high propensity for malignant transformation. The histomorphology of BAF with malignant transformation can show a spectrum of changes ranging from benign, dysplastic to frank malignancy. Thus, the diagnosis of BAF imposes the pursuit of dysplasia/ malignancy focus. We presented a case of intrahepatic cholangiocarcinoma arising from BAF in a 49-year-old woman with detailed histomorphology. We also performed a PubMed database search and tabulated all previously reported cases of BAF with dysplasia/ malignant transformation. A statistic comparison of age, sex ratio, size of the tumor, and survival following complete resection between BAFs with and without dysplasia/ malignancy from the retrieved data is presented. Our analysis did not highlight any statistically significant difference between BAFs with and without dysplasia/ malignancy in age, sex ratio, tumor size, and survival following complete surgical resection. Our study highlights the histopathology and immunohistochemistry of a case of BAF with malignant transformation and highlights the importance of this diagnosis in management. Further longitudinal studies on a larger cohort of patients are required to validate our findings.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023453"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Small cell neuroendocrine carcinoma with adenocarcinoma and high grade squamous intraepithelial neoplasia of the cervix.","authors":"Guralarasan Gurubalan, Amber Parwaiz, Surabhi Ajit, Tarun Kumar, Madhu Kumari, Punam Bhadani","doi":"10.4322/acr.2023.452","DOIUrl":"10.4322/acr.2023.452","url":null,"abstract":"<p><p>Neuroendocrine neoplasm (NEN) of the cervix is a malignant tumor and is classified into low and intermediate-grade neuroendocrine tumor (NET), and high-grade small cell neuroendocrine carcinoma (SCNEC), and large cells neuroendocrine carcinoma (LCNEC). SCNEC of the cervix is an Infrequent tumor with an incidence of less than 1% of all gynecological malignancies. It is characterized by small to medium-sized tumor cells with scant cytoplasm and neuroendocrine differentiation. Most cases of SCNEC of the cervix manifest in pure forms, and only cases show coexisting, non-neuroendocrine component of HPV-associated adenocarcinoma or squamous cell carcinoma. In this report, reviewing the literature, we present one such unique case of SCNEC of the cervix with adenocarcinoma and high-grade squamous intraepithelial neoplasia.</p>","PeriodicalId":53117,"journal":{"name":"Autopsy and Case Reports","volume":"13 ","pages":"e2023452"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}